Apoptosis: Pogramlanmış hücre ölümleri
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info:eu-repo/semantics/openAccess
Özet
Normal gelişimin ve hastalıklarla bağlantılı patolojik durumların bir öğesi olarak ortaya çıkabilen "proglamlanmış hücre ölümleri" çok hücreli pek çok canlıda bulunmuştur. Programlanmış hücre ölümleri veya diğer adı ile apoptosis, belirli hücrelerin kendi ölümlerini, yani "intiharlarını", aldıkları sinyal sonucu aktive etmeleridir. Apoptosis nematodlardan memelilere kadar pek çok organizmanın hücre ve doku çeşidinde tanımlanmıştır. Apoptosis, nekrozdan farklı olarak, ölen hücrenin aktif katılımı ile meydana gelir. Yani, "intihar et" komutu alan hücre bu olayı gerçekleştirmek için bazı gen ürünleri (proteinler, enzimler) sentezler ve gerekli fizyolojik düzenlemeleri gerçekleştirir. Apoptosis'i gerçekleştiren genler hayvanlarda ve bitkilerde bulunmuştur. Bu genlerin bir kısmı apoptosis'de indükleyici bir kısmı bir inhibitor gibi davranır. Değişik organizmalardaki apoptosis ile bağlantılı genler arasında, DNA dizilimi açısından, benzerlik bulunması evrimsel açıdan canlılar arasında korunmuş ortak bir programlanmış hücre ölüm mekanizmalarının varlığını akla getirmiştir. Apoptosis'in canlılardaki rolü, hayvanlarda olduğu gibi normal gelişimle ilgili olabileceği gibi, bitkilerdeki "aşırı duyarlı tepkime"de olduğu gibi patojenlere karşı savunma mekanizması ile ilgili de olabilir.
Programmed cell death" has been found in many multicellular organisms and occurs as a part of normal development as well as in pathological processes associated with some diseases. Programmed cell death, or apoptosis, is the process whereby certain cells are induced to activate their own death or cell suicide. Apoptosis has been described in a wide variety of cell and tissue types from nematodes to mammals. Apoptosis, unlike necrosis, is mediated by the active participation of dying cells. In another words, the dying cells synthesize certain proteins and enzymes to carry out the "suicide" process. The genes involved in apoptosis have been defined in animals as well as in plants. Some of these genes act as inducers while the others as inhibitors. It has been found that apoptosis related genes have high homology in terms of DNA sequences, suggesting the occurence of an evolutionarily preserved common programmed cell death mechanism among multicellular organisms. The possible role of apoptosis may be related to the regulation of normal development as in animals or it may be involved in defense responses against pathogens as in hypersensitive response (HR) in plants.
Programmed cell death" has been found in many multicellular organisms and occurs as a part of normal development as well as in pathological processes associated with some diseases. Programmed cell death, or apoptosis, is the process whereby certain cells are induced to activate their own death or cell suicide. Apoptosis has been described in a wide variety of cell and tissue types from nematodes to mammals. Apoptosis, unlike necrosis, is mediated by the active participation of dying cells. In another words, the dying cells synthesize certain proteins and enzymes to carry out the "suicide" process. The genes involved in apoptosis have been defined in animals as well as in plants. Some of these genes act as inducers while the others as inhibitors. It has been found that apoptosis related genes have high homology in terms of DNA sequences, suggesting the occurence of an evolutionarily preserved common programmed cell death mechanism among multicellular organisms. The possible role of apoptosis may be related to the regulation of normal development as in animals or it may be involved in defense responses against pathogens as in hypersensitive response (HR) in plants.
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Turkish Journal of Zoology
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24
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supp
