Çocuklarda tonsillektomi sonrası kusma profilaksisinde metilprednizolon ve deksametazon’un karşılaştırılması
Yükleniyor...
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çalışmamızda orta etki süreli bir glukokortikoid olan metilpednizolonun tonsillektomi ve/veya adenoidektomi operasyonları sonrası kusmayı önlemedeki etkinliğini, deksametazon ile karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya tonsillektomi ve/veya adenoidektomi operasyonu planlanan 110 hasta alındı. Operasyona alınan tüm hastalar randomize edilerek iki gruba ayrıldı. Genel anestezi sonrası cerrahi başlamadan önce; bir gruba deksametazon 0,5 mg kg-1 (maksimum 8 mg) (Grup D) ve diğer gruba metilprednizolon 2,5 mg kg-1 (maksimum 40 mg) (Grup M) intravenöz olarak uygulandı. Postoperatif dönemde uyanma odasında 2 saat (erken dönem) ve sonraki 24 saat (geç dönem) süreyle; kusma sıklığı, ilk analjezik yapılma zamanı, cheops ağrı skoru (15. dk., 1., 2., 4. saatlerde), oral alım kalitesi ve yan etkiler değerlendirilerek kaydedildi. Bulgular: Gruplar arasında özellikleri açısından anlamlı fark saptanmadı. Gruplar arasında erken dönemdeki kusma sıklığı ve geç dönemdeki kusma sıklığı açısından anlamlı bir fark yoktu (p>0.05). Gruplar arasında ilk analjezik yapma zamanı açısından ve oral alım kalitesi açısından anlamlı bir fark saptanmadı (p>0.05). Yan etkiler iki grup arasında benzer bulundu. Sonuç: Çalışmamızda; tonsillektomi sonrası kusmayı önlemede, yan etki insidansını artırmadan, metilprednizolonun deksametazon kadar etkili olduğu ve deksametazona alternatif olarak kullanılabileceği kanısına varıldı
Objective: In the present study we aimed to compare the effects of methyl perdnisolone, an intermediate acting glucocorticoid, on preventing vomiting after tonsillectomy or adenoidectomy with that of dexamethasone. Material and Methods: A total of 110 patients going under tonsillectomy or adenoidectomy were included to the study. Patients were randomized into two groups. Group D was administered dexamethasone 0.5 mg/kg (max 8 mg) intravenously following general anesthesia before surgery was started whereas group M was administered methyl prednisolone 2.5 mg kg-1 (max 40 mg). Patients were assessed for 2 hours in the post-op room (early stage) and the following 24 hours (late stage) and incidence of vomiting, the first analgesic administration time, cheops pain score (at 15 min, 1 hour, 2hrs and 4 hrs after surgery) and oral intake quality were recorded. Results: Demographic data did not differ between groups. There was not statistically significant difference in the incidence of early stage or late stage vomiting between the two groups (p>0.05). We did not find statistically significant difference in the time of first analgesic administration between the two group (p>0.05). Side effects were similar in the two groups. Conclusion: We suggest that prednisolone is as effective as dexamethasone in preventing vomiting after tonsillectomy without causing further side effects and that it could be used as an alternative agent when latter is unavailable.
Objective: In the present study we aimed to compare the effects of methyl perdnisolone, an intermediate acting glucocorticoid, on preventing vomiting after tonsillectomy or adenoidectomy with that of dexamethasone. Material and Methods: A total of 110 patients going under tonsillectomy or adenoidectomy were included to the study. Patients were randomized into two groups. Group D was administered dexamethasone 0.5 mg/kg (max 8 mg) intravenously following general anesthesia before surgery was started whereas group M was administered methyl prednisolone 2.5 mg kg-1 (max 40 mg). Patients were assessed for 2 hours in the post-op room (early stage) and the following 24 hours (late stage) and incidence of vomiting, the first analgesic administration time, cheops pain score (at 15 min, 1 hour, 2hrs and 4 hrs after surgery) and oral intake quality were recorded. Results: Demographic data did not differ between groups. There was not statistically significant difference in the incidence of early stage or late stage vomiting between the two groups (p>0.05). We did not find statistically significant difference in the time of first analgesic administration between the two group (p>0.05). Side effects were similar in the two groups. Conclusion: We suggest that prednisolone is as effective as dexamethasone in preventing vomiting after tonsillectomy without causing further side effects and that it could be used as an alternative agent when latter is unavailable.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türk Anestezi ve Reanimasyon Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
5
