IS METHOTREXATE-INDUCED TESTICULAR DAMAGE PREVENTABLE USING NETTLE SEED EXTRACT: A HISTOPATHOLOGICAL, IMMUNOHISTOCHEMICAL, BIOCHEMICAL AND SPERMATOLOGICAL EXAMINATION

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dc.authoriddogan, abdulahad/0000-0002-5438-8560
dc.contributor.authorUyar, Ahmet
dc.contributor.authorYaman, Turan
dc.contributor.authorDogan, Abdulahad
dc.contributor.authorUslu, Sema
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorYener, Zabit
dc.contributor.authorCelik, Ismail
dc.date.accessioned2024-09-18T20:32:50Z
dc.date.available2024-09-18T20:32:50Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractIn the study 32 Wistar albino rats were divided into four group as control (Group Control, n=8), methotrexate (Group MTX, n=8), MTX + UDS (Group MTX+UDS, n=8) and Urtica dioica seed extract (UDS) (Group UDS, n=8). After the trial, blood and post-necropsy testicular tissue samples were taken. Histopathological examinations showed that methotrexate had an adverse impact on spermatogenesis by damaging testicles; however, such damages were substantially decreased in the Group MTX+UDS. In the immunohistochemical examinations glutathione peroxidase 1 (GPx1) immunoreactive areas was higher in the Group MTX + UDS compared to the Group MTX. Biochemical examinations revealed that the level of malondialdehyde (MDA), glutathione (GSH), glutathione S-transferase (GST) and catalase (CAT) enzymes levels statistically significantly differenced (p<0.001) in the Group MTX compared to the control, UDS and MTX+UDS groups. There were significant (p<0.05) differences the Group MTX from Group MTX+UDS. such as density, motility, dead-live sperm rate and abnormal sperm rate. Our study results showed that UDS prevented the damage occurred in the testicles according to histopathological, immunohistochemical, biochemical and spermatological findings.en_US
dc.description.sponsorshipYuzuncu Yil University, Department of Scientific Research Projects [2015-HIZ-VF046, 1523]en_US
dc.description.sponsorshipWe would like to thank to Yuzuncu Yil University, Department of Scientific Research Projects [Project Code: 2015-HIZ-VF046 (ID Number: 1523)].en_US
dc.identifier.endpage2331en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4en_US
dc.identifier.startpage2320en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11152
dc.identifier.volume27en_US
dc.identifier.wosWOS:000430372900044en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexateen_US
dc.subjectUrtica dioica seed extracten_US
dc.subjectPathologyen_US
dc.subjectTesticlesen_US
dc.titleIS METHOTREXATE-INDUCED TESTICULAR DAMAGE PREVENTABLE USING NETTLE SEED EXTRACT: A HISTOPATHOLOGICAL, IMMUNOHISTOCHEMICAL, BIOCHEMICAL AND SPERMATOLOGICAL EXAMINATIONen_US
dc.typeArticleen_US

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