The evaluation of the therapeutic potential of hesperetin on diethylnitrosamine and phenobarbital induced liver injury in rats

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dc.authoridKISACAM, Mehmet Ali/0000-0003-0521-9434
dc.authoridKaya Tektemur, Nalan/0000-0001-8880-4932
dc.contributor.authorKisacam, Mehmet Ali
dc.contributor.authorKocamuftuoglu, Gonca Ozan
dc.contributor.authorTektemur, Nalan Kaya
dc.contributor.authorOzan, Penbe Sema Temizer
dc.date.accessioned2024-09-18T20:02:34Z
dc.date.available2024-09-18T20:02:34Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractNitrite and amine reactions can occur rapidly and produce nitrosamines, in-vivo. Diethylnitrosamine (DEN) and phenobarbital (PB) are readily inducing liver injury and hesperetin (HES), as a flavonoid found in citrus fruits, have the potential to compensate for their harmful effects. In this study, the therapeutic effects of HES were evaluated in DEN and PB mediated liver defect. Adult male Sprague-Dawley rats were split into 5 groups (n=10): Control, DEN, DEN+PB, HES, and DEN+PB+HES. 150 mg/kg DEN was applied intraperitoneally to DEN groups. Fifteen days after the DEN application 500ppm of PB was given in drinking water. HES were administered at 50 mg/kg dose orally for 8 weeks. Blood and liver malondialdehyde (MDA), glutathione (GSH) levels, and catalase (CAT), superoxide dismutase (SOD) activities were measured spectrophotometrically. Moreover, histologic examination of liver sections and apoptosis were determined with hematoxylin-eosin and TUNEL methods, respectively. DEN-PB application was found to increase blood and liver MDA levels and liver CAT activity, oppositely, decreased blood and liver SOD activity, GSH levels, and blood CAT activity. HES was found to have a positive impact on oxidative stress parameters by decreasing liver and blood MDA activity, increasing blood CAT and SOD activity together with liver GSH levels and SOD activity. Whereas DEN and PB application increased all histopathological findings and TUNEL positive cells, HES administration decreased these findings which might be important for the protection of liver cell structure from cell damage. These results suggest that HES administration could be an alternative therapeutic approach to liver damage.en_US
dc.description.sponsorship[VF.16.22]en_US
dc.description.sponsorshipThis research was supported by a grant supplied from Firat University Research Fund (VF.16.22) .en_US
dc.identifier.doi10.33988/auvfd.812718
dc.identifier.endpage156en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85127962969en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage149en_US
dc.identifier.trdizinid1129817en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.812718
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1129817
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7872
dc.identifier.volume69en_US
dc.identifier.wosWOS:000777520900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectdiethylnitrosamineen_US
dc.subjecthesperetinen_US
dc.subjectoxidative stressen_US
dc.subjectphenobarbitalen_US
dc.titleThe evaluation of the therapeutic potential of hesperetin on diethylnitrosamine and phenobarbital induced liver injury in ratsen_US
dc.typeArticleen_US

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