The Prognostic Importance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Adult Patients with Sepsis Who Underwent Hemoperfusion in General Intensive Care Unit

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dc.contributor.authorKoc, Suna
dc.contributor.authorOzer, Turkan
dc.contributor.authorDokur, Mehmet
dc.contributor.authorKucukcerit, Taner Serif
dc.contributor.authorKaraoguz, Burcu
dc.contributor.authorCelep, Yunus Emre
dc.contributor.authorAktepe, Emre
dc.date.accessioned2024-09-18T20:56:56Z
dc.date.available2024-09-18T20:56:56Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Sepsis is a major cause of mortality and morbidity in the intensive care units. The goal of this study is to investigate whether changes in the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are a prognostic marker for patients with sepsis (according to sepsis stages, and patient's and disease's characteristics) who have been followed up in the intensive care unit and who have received HA330 resin-directed hemadsorption column for sepsis. Methods: The study included a group of 100 (male [healed: 19, exitus: 42], female [cured: 29, exitus: 10]) sepsis patients who were followed up in the intensive care unit between December 2019 and December 2021 and who received HA-330 sepsis adsorption column. Results: Although a strong positive correlation was found between the neutrophil-to-lymphocyte ratio and the baseline platelet-to-lymphocyte ratio values (r = 0.725 and P = .001), a weak positive correlation was found between the baseline neutrophil-to-lymphocyte ratio and the comorbidity values (r = 0.253 and P = .001). In addition, the period found for hemoperfusion in those who healed was statistically significantly higher in exitus patients (P = .001). It was noted that the improvement in repeated neutrophil-to-lymphocyte ratio measurements in the healing and death observations was identical (P > .05). The repeated neutrophil-to-lymphocyte ratio measurement values were found to be statistically significantly different for those with healing (P = .014). In addition, repeated neutrophil-to-lymphocyte ratio measurement values were found to be statistically significantly different from those with exitus (P = .001). It was observed that the change of repeated platelet-to-lymphocyte ratio measurements in the observations with healing and death was statistically significant (P < .05). Conclusion: It is thought that it may be a cheap and useful biomarker in the prognosis of patients who are followed up in the intensive care unit and are treated with HA-330 sepsis adsorption column since the rate of neutrophils and lymphocytes in patients with hematological healing and death differs greatly.en_US
dc.identifier.doi10.54614/eurjther.2022.0060
dc.identifier.endpage44en_US
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue1en_US
dc.identifier.startpage37en_US
dc.identifier.trdizinid522153en_US
dc.identifier.urihttps://doi.org/10.54614/eurjther.2022.0060
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/522153
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12188
dc.identifier.volume28en_US
dc.identifier.wosWOS:000800651900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCordusen_US
dc.relation.ispartofEuropean Journal of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSepsisen_US
dc.subjecthemoperfusionen_US
dc.subjectneutrophilsen_US
dc.subjectlymphocytesen_US
dc.subjectblood plateletsen_US
dc.subjectratioen_US
dc.subjectintensive care unitsen_US
dc.titleThe Prognostic Importance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Adult Patients with Sepsis Who Underwent Hemoperfusion in General Intensive Care Uniten_US
dc.typeArticleen_US

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