Anticandidal Activity and Anticandidal Mechanism of Essential Oil of Cuminum cyminum L. and Myrtus communis L. Mixture

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dc.authoridErdogan Eliuz, Elif/0000-0003-4317-3000
dc.authoridBAHADIRLI, NADIRE PELIN/0000-0001-7321-5377
dc.contributor.authorEliuz, Elif Ayse Erdogan
dc.contributor.authorBahadirli, Nadire Pelin
dc.date.accessioned2024-09-18T20:13:38Z
dc.date.available2024-09-18T20:13:38Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractC. cyminum (cumin) and M. communis (myrtle) comprise many biologically active molecules. In this study, cumin seed and myrtle leaves were mixed then hydrodistilled and analyzed by GC-MS. The main components of the essential oil were cuminal (50.71%), 1,8 cineole (8.30%), O-cymene (7.88%), beta-pinene (7.62%), a-pinene (7.16%),.-terpinene (6.09%) and a-terpinolene (2.19%). The antifungal activity of the essential oil against C. albicans, C. parapsilosis and C. tropicalis was investigated using spectrophotometric broth microdilution, colorimetric broth microdilution, and agar well diffusion tests. Antimicrobial mechanism of the EO was researched by TTC-dehydrogenase relative activity, protein and DNA leakage analysis. While the MIC values of the oil were 3.29 mg mL(-1) for C. albicans, 3.57 mg mL(-1) for C. parapsilosis and 3.65 mg mL(-1) for C. tropicalis, the 50% cytotoxic concentration values were between 0.17 mg mL(-1) and 2.61 mg mL(-1) for Candida species. The inhibition values against yeasts in dark and light conditions were found as 42.1 mm on C. parapsilosis and 39 mm on C. tropicalis exposed dark and light, respectively. The inhibition zones of oil in water, glucose, glycerol and salt environment. As a result, the highest IZ was found as 26.6 mm on C. albicans and 26 mm on C. tropicalis in the presence of a 3% glycerol environment. The DNA and protein levels were increased when yeast was exposed to the EO. As a result, the oil of mixed C. cyminum and M. communis preserved its antimicrobial stability in different environmental conditions and should contribute to new antifungal research.en_US
dc.identifier.doi10.18016/ksutarimdoga.vi.1075012
dc.identifier.endpage401en_US
dc.identifier.issn2619-9149
dc.identifier.startpage391en_US
dc.identifier.trdizinid1169515en_US
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.1075012
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1169515
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9301
dc.identifier.volume25en_US
dc.identifier.wosWOS:000956730400012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKahramanmaras Sutcu Imam Univ Rektorluguen_US
dc.relation.ispartofKsu Tarim Ve Doga Dergisi-Ksu Journal of Agriculture and Natureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCuminen_US
dc.subjectMyrtleen_US
dc.subjectEssential oilen_US
dc.subjectAnticandidalen_US
dc.subjectAntifungalen_US
dc.titleAnticandidal Activity and Anticandidal Mechanism of Essential Oil of Cuminum cyminum L. and Myrtus communis L. Mixtureen_US
dc.typeArticleen_US

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