Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model

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dc.contributor.authorKarcıoğlu, Murat
dc.contributor.authorTuzcu, Kasım
dc.contributor.authorSefil, Fatih
dc.contributor.authorDavarcı, Işıl
dc.contributor.authorAydın, Suzan
dc.contributor.authorSarı, Ali
dc.contributor.authorAydoğan, Akın
dc.contributor.authorÖzden, Raif
dc.date.accessioned2019-07-16T15:55:29Z
dc.date.available2019-07-16T15:55:29Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Cardiac toxicity due to the administration of local anesthetics may be fatal. In this study, we evaluated the efficacy of a 20% lipid solution combined with epinephrine in a levobupivacaine-induced cardiac arrest model. Materials and methods: A total of 14 New Zealand rabbits were sedated and mechanically ventilated. Asystole was induced with intravenous levobupivacaine injection. The rabbits were randomized into groups receiving the same volume of either 0.9% saline (CR group) or a 20% lipid solution (LE group) along with a 100 µg/kg epinephrine bolus, which were administered immediately upon asystole. Standard advanced cardiac life support protocols were performed. Results: Four subjects in the LE group as well as 3 subjects in the CR group had a spontaneous recovery (P = 0.592). In the 20th minute after arrest, 3 subjects in the LE group had maintained spontaneous circulation, while there was only 1 subject from the CR group with the same outcome. Conclusion: We found that adding a lipid solution to epinephrine for the resuscitation of rabbits that underwent levobupivacaineinduced cardiac arrest increased recovery rates of circulation and therefore the likelihood of survival. Further studies are needed to develop clinical therapies for the systemic toxicity of local anesthetics.en_US
dc.description.abstractAim: Cardiac toxicity due to the administration of local anesthetics may be fatal. In this study, we evaluated the efficacy of a 20% lipid solution combined with epinephrine in a levobupivacaine-induced cardiac arrest model. Materials and methods: A total of 14 New Zealand rabbits were sedated and mechanically ventilated. Asystole was induced with intravenous levobupivacaine injection. The rabbits were randomized into groups receiving the same volume of either 0.9% saline (CR group) or a 20% lipid solution (LE group) along with a 100 µg/kg epinephrine bolus, which were administered immediately upon asystole. Standard advanced cardiac life support protocols were performed. Results: Four subjects in the LE group as well as 3 subjects in the CR group had a spontaneous recovery (P = 0.592). In the 20th minute after arrest, 3 subjects in the LE group had maintained spontaneous circulation, while there was only 1 subject from the CR group with the same outcome. Conclusion: We found that adding a lipid solution to epinephrine for the resuscitation of rabbits that underwent levobupivacaineinduced cardiac arrest increased recovery rates of circulation and therefore the likelihood of survival. Further studies are needed to develop clinical therapies for the systemic toxicity of local anesthetics.en_US
dc.identifier.endpage336en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.pmid25536745en_US
dc.identifier.scopus2-s2.0-84892411067en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage330en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TWpFek1EWTJOZz09
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2073
dc.identifier.volume44en_US
dc.identifier.wosWOS:000329790100026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleEfficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest modelen_US
dc.typeArticleen_US

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