Direct-acting antiviral therapy may help restore HCV-induced impaired redox balance and liver fibrosis process

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dc.authoridCirkin Doruk, Berfin/0000-0002-5370-4197
dc.authoridcabalak, mehmet/0000-0003-1148-2247
dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.contributor.authorBal, Tayibe
dc.contributor.authorDogan, Serdar
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorCabalak, Mehmet
dc.contributor.authorCirkin, Berfin
dc.date.accessioned2024-09-18T20:15:14Z
dc.date.available2024-09-18T20:15:14Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to investigate the changes in thiol/disulfide balance, pro-fibrotic mediators (transforming growth factor-beta [TGF-beta] and periostin) and a potential biomarker for the prediction of HCV-induced HCC (3 beta-hydroxysterol Delta 24-reductase [DHCR24]) during direct-acting antiviral (DAA) therapy in chronic hepatitis C (CHC) patients. Methods: This prospective cohort study included 56 non-cirrhotic, treatment-naive CHC patients who were treated with DAAs between January and June 2020. Laboratory tests, including serum total/native thiol, TGF-beta, periostin, DHCR24, total bilirubin and albumin levels were measured and disulfide levels were calculated at baseline, then at 1 month and at the end of therapy (EOT). Results: Of the 56 patients, all achieved a sustained virological response after DAA therapy. There was a significant decrease in serum levels of disulfide and TGF-beta, (p=0.020 and p<0.001, respectively) and a significant increase in serum levels of native thiol compared with baseline levels (p=0.010). There was no significant change in levels of total thiol, DHCR24 and periostin levels. Serum TGF-beta levels were found to be positively correlated with total bilirubin levels (r(s)=0.470, p=0.001) and negatively with albumin levels (r(s)=-0.483, p<0.001). Asignificant moderate positive correlation was determined between baseline serum DHRC24 and disulfide levels (r(s)=0.356, p=0.007). Conclusions: The study results suggest that the DAA therapy may help to restore the impaired thiol/disulfide balance and reduce the pro-fibrotic process in CHC patients by markedly decreasing serum levels of TGF-beta, a key player in HCV-induced liver fibrosis.en_US
dc.identifier.doi10.1515/tjb-2022-0081
dc.identifier.endpage50en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85142921367en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage44en_US
dc.identifier.trdizinid1252495en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0081
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1252495
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9527
dc.identifier.volume48en_US
dc.identifier.wosWOS:000889933800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdirect-acting antiviral agents (DAA)en_US
dc.subjectdisulfideen_US
dc.subjecthepatitis C virus (HCV)en_US
dc.subjectTGF-betaen_US
dc.subjectthiolen_US
dc.titleDirect-acting antiviral therapy may help restore HCV-induced impaired redox balance and liver fibrosis processen_US
dc.typeArticleen_US

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