Cardiotoxic effects of enrofloxacin on electrophysiological activity, cardiac markers, oxidative stress, and haematological findings in rabbits

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dc.contributor.authorDurgut, Ramazan
dc.contributor.authorÖztürk, Oktay Hasan
dc.contributor.authorNacar, Ahmet
dc.contributor.authorÖztürk Sağkan, Aliye
dc.date.accessioned2019-07-16T16:00:49Z
dc.date.available2019-07-16T16:00:49Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this research was to investigate the effect of normal and high doses of enrofloxacin on basal electrocardiographic (ECG) parameters including corrected QT (QTc) values along with biochemical and haematological findings in healthy rabbits. In total 21 New Zealand rabbits were used. The animals were randomly divided into three groups including 7 rabbits in each. The normal dose (5 mg/kg) of enrofloxacin and a toxic dose (50 mg/kg) were given intravenously in group 1, and the normal dose was given for 6 weeks in group 2. The last group was designated as a negative control (group 3). ECG, serum biochemistry parameters, and total antioxidant capacity (TAC) and total oxidant status (TOS) were determined every week. At the end of the experiment, necropsy was performed and histology was evaluated. Some oxidative parameters were measured in the heart tissue. No cardiotoxic effect was observed on ECG, in biochemical or haematological findings, or macroscopic or histological findings in groups 2 and 3. The results indicated that enrofloxacin is not harmful for the heart in clinically healthy rabbits at normal and toxic doses compared with the negative control group in terms of ECG, biochemical or haematological findings, or macroscopic or histological findings.en_US
dc.description.abstractThe aim of this research was to investigate the effect of normal and high doses of enrofloxacin on basal electrocardiographic (ECG) parameters including corrected QT (QTc) values along with biochemical and haematological findings in healthy rabbits. In total 21 New Zealand rabbits were used. The animals were randomly divided into three groups including 7 rabbits in each. The normal dose (5 mg/kg) of enrofloxacin and a toxic dose (50 mg/kg) were given intravenously in group 1, and the normal dose was given for 6 weeks in group 2. The last group was designated as a negative control (group 3). ECG, serum biochemistry parameters, and total antioxidant capacity (TAC) and total oxidant status (TOS) were determined every week. At the end of the experiment, necropsy was performed and histology was evaluated. Some oxidative parameters were measured in the heart tissue. No cardiotoxic effect was observed on ECG, in biochemical or haematological findings, or macroscopic or histological findings in groups 2 and 3. The results indicated that enrofloxacin is not harmful for the heart in clinically healthy rabbits at normal and toxic doses compared with the negative control group in terms of ECG, biochemical or haematological findings, or macroscopic or histological findings.en_US
dc.identifier.endpage521en_US
dc.identifier.issn1300-0179
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84973334720en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage513en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TWpFME1EZzBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2508
dc.identifier.volume40en_US
dc.identifier.wosWOS:000378691500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Zoologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiyolojien_US
dc.titleCardiotoxic effects of enrofloxacin on electrophysiological activity, cardiac markers, oxidative stress, and haematological findings in rabbitsen_US
dc.typeArticleen_US

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