Hemostatic effects of traditional Inula viscosa and Capsella bursa-pastoris plant mixture extract on rat liver parenchymal bleeding model

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dc.authoridGuzel, Yelda/0000-0002-7975-3130
dc.contributor.authorOzturk, Ozan Utku
dc.contributor.authorUgur, Mustafa
dc.contributor.authorGuzel, Yelda
dc.contributor.authorOzturk, Mehmet Ali
dc.contributor.authorGursoy, Didar
dc.contributor.authorDogan, Serdar
dc.contributor.authorTemiz, Muhyittin
dc.date.accessioned2024-09-18T20:04:34Z
dc.date.available2024-09-18T20:04:34Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: Failure to achieve effective bleeding control and problems related to transfusion in liver surgery are the most common causes of post-operative mortality and morbidity. Various methods/drugs including topical hemostatic agents have been employed for bleeding control in liver surgery. This study was aimed to investigate the hemostatic properties of the herb mixture extract of Inula viscosa and Capsella bursa-pastoris (IvCbp) in rat liver laceration model, which have been traditionally used as antiseptic and hemostatic agents public in Hatay/Tukey. METHODS: Thirty rats were divided into three groups equally and blood samples were taken from all rats for preoperative hemoglobin (Hb) measurements. Then, the standard liver resection model was applied to all rats. Sponge for the first rat group, Ankaferd Blood Stopper (R) Trend-Tech for the second rat group and IvCbp plant extract mixture for the third group were applied to resection areas for 3 minutes. Liver samples of all rats were evaluated in terms of inflammation and necrosis intensity on the 5th post-operative day. RESULTS: operative Hb values were found as 11.0 +/- 1.1 g/dL in the sponge group, 11.9 +/- 2.0 g/dL in the Ankaferd group, and 14.I +/- 1.2 g/dL in the IvCbp herb mixture group (p<0.001). In the histopathological examination, less necrosis was observed in the herb mixture group compared to the sponge and Ankaferd groups (p=0.001). In addition, no statistically significant necrosis difference was observed between sponge and Ankaferd groups. While less inflammation was observed in the herb mixture group compared to the other groups, Ankaferd group had the highest inflammation score (p<0.001). CONCLUSION: IvCbp herb mixture extract group provide effective hemostatic control, caused less Hb decrease and resulted in less inflammation and necrosis compared to Ankaferd and sponge groups in a rat liver resection model.en_US
dc.identifier.doi10.14744/tjtes.2022.90838
dc.identifier.endpage1065en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue8en_US
dc.identifier.pmid35920433en_US
dc.identifier.scopus2-s2.0-85135304041en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1059en_US
dc.identifier.trdizinid1137384en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2022.90838
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1137384
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8254
dc.identifier.volume28en_US
dc.identifier.wosWOS:000858853800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBleedingen_US
dc.subjectCapsella bursa-pastorisen_US
dc.subjectethnomedicineen_US
dc.subjecthemostasisen_US
dc.subjectInula viscosaen_US
dc.subjectliver surgeryen_US
dc.titleHemostatic effects of traditional Inula viscosa and Capsella bursa-pastoris plant mixture extract on rat liver parenchymal bleeding modelen_US
dc.typeArticleen_US

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