Effect of silibinin on the hyperlipidemia in rats fed with high cholesterol diet

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dc.authoridduman, dildar/0000-0001-8680-8550
dc.contributor.authorDuman, Didem
dc.contributor.authorArpaci, Abdullah
dc.contributor.authorDirican, Emre
dc.contributor.authorBozdogan, Server
dc.contributor.authorBayraktar, Hamdullah Suphi
dc.date.accessioned2024-09-18T20:57:03Z
dc.date.available2024-09-18T20:57:03Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Despite current hypolipidemic drugs, the search for a more effective hypolipidemic agent is ongoing. In this study, it was aimed to investigate the effect of Silibinin on hyperlipidemia in rats fed high cholesterol diet (HCD). Materials and Methods: Rats were made obese. Rats were given egg yolk for 60 days and then 50 mg/kg, 100 mg/kg Silibinin were applied i.p. for 7 days. Results: The first and last weights of the rats were significantly different. While total cholesterol (TC), LDL, TG and VLDL levels increased significantly in the groups fed with HCD, HDL level reduced compared to control group (CG). OxLDL and TAS were significantly different between groups. Conclusion: The effects of Silibinin on serum LDL, TC, VLDL, HDL, TG, OxLDL levels and to observe the antioxidant effect, TAS and TOS were investigated in experimental obese rat models. It was concluded that Silibinin plays an effective role in lowering TG and LDL levels, increasing HDL levels and decreasing hepatic lipid accumulation in HCD rats at 100 mg/kg dose. The use of Silibinin does not cause antihyperlipidemic effect but has antioxidant effect.en_US
dc.description.sponsorshipHatay Mustafa Kemal University [18.YL.023]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University, Coordinatorship of Scientific Research Projects. Project no: 18.YL.023en_US
dc.identifier.doi10.17826/cumj.788377
dc.identifier.endpage131en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage125en_US
dc.identifier.trdizinid429338en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.788377
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/429338
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12261
dc.identifier.volume46en_US
dc.identifier.wosWOS:000632797000015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilibininen_US
dc.subjecthyperlipidemiaen_US
dc.subjectantioxidanten_US
dc.subjectatherosclerosisen_US
dc.titleEffect of silibinin on the hyperlipidemia in rats fed with high cholesterol dieten_US
dc.typeArticleen_US

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