EFFECT OF GM-CSF LEVELS ON OSTEOPOROSIS IN POSTMENOPAUSAL PERIOD
[ N/A ]
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Carbone Editore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Cytokines and hematopoietic growth factors may play a role in the pathogenesis of osteoporosis. The aim of this study was to assess the relationship between osteoporosis (OP) and granulocyte-macrophage colony stimulating factor (GM-CSF) in postmenopausal period. Materials and methods: Total number of 80 female patients between the ages of 45-75 and who had entered in menopause from at least one year and diagnosed with OP were enrolled in this study. As a control group, 80 healthy volunteer female patients who had entered in menopause from at least one year and had no diagnosis of OP were selected. The age, height, weight, body mass index, duration of menopause, exercise habits of the patients and controls were recorded and bone mineral density was measured for the diagnosis of OP. The serum GM-CSF concentrations of individuals were quantified using a specific enzyme immunoassay kit. Results: There was no significant relationship between the mean age, duration of menopause and body mass index of patients and controls (p>0.05). Serum GM-CSF levels of patients and control groups did not differ significantly (p> 0.05). Conclusion: The results of our study showed that there was no significant correlation between osteoporosis and serum GMCSF levels. Osteoporosis might be correlating with the levels of GM-CSF in bone microenvironment rather than serum levels.
Açıklama
Anahtar Kelimeler
Osteoporosis, granulocyte-macrophage colony stimulating factor, menopause
Kaynak
Acta Medica Mediterranea
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
30
Sayı
1
