Porous alginate hydrogel beads cross-linked with citric acid containing tannic acid: structural analysis, antimicrobial properties and release behavior

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dc.contributor.authorBucak, Celile Demirbilek
dc.date.accessioned2024-09-18T19:52:34Z
dc.date.available2024-09-18T19:52:34Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, in order to combine more than one feature in a single material structure, a natural polymer sodium alginate (Na-Alg) and phenolic compound Tannic acid (TA) were combined and cross-linked with a natural compound citric acid (CA). The basis of this study is to rapidly prepare hydrogel beads from Na-Alg/TA by dropping a small organic molecule into citric acid as a crosslinking agent instead of traditional divalent metal salts such as CaCl2. Primarily, an alginate complex containing various ratios of TA was prepared. Then, alginate/TA/CA (ATC) spheres were synthesized using an ionotropic method by dripping this mixture into the CA solution. Hydrogel spheres prepared by CA crosslinking the TA/alginate complex are based on strong hydrogen bond interaction. The synthesized hydrogel beads were characterized by various methods (ATR-FTIR, XRD, SEM, TGA, and DSC) and the importance of TA incorporation into the structure was explained. The release of phenolic compound from the spheres in SIF and SGF medium was investigated. Encapsulation of TA in suitable polymeric material and studying its release are an important work for curative medicine and tissue engineering. This new material will provide a new insight for the preparation of multifunctional biocomposite spheres with antimicrobial properties, and good swelling behavior.en_US
dc.identifier.doi10.1007/s10570-022-04947-2
dc.identifier.endpage1132en_US
dc.identifier.issn0969-0239
dc.identifier.issn1572-882X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85142657680en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1117en_US
dc.identifier.urihttps://doi.org/10.1007/s10570-022-04947-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7528
dc.identifier.volume30en_US
dc.identifier.wosWOS:000888701200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCelluloseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlginateen_US
dc.subjectTannic aciden_US
dc.subjectCitric acid hydrogelen_US
dc.subjectHydrogel beadsen_US
dc.titlePorous alginate hydrogel beads cross-linked with citric acid containing tannic acid: structural analysis, antimicrobial properties and release behavioren_US
dc.typeArticleen_US

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