Association of cardiovascular calcifications with coronary artery disease
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Dosyalar
Tarih
2004
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info:eu-repo/semantics/openAccess
Özet
Çalışmanın amacı koroner anjiyografi yapılan hastalarda, torasik aortadaki aterom plağı kalsifikasyonu veya aort kapak kalsifikasyonu ile koroner arter hastalığı arasındaki ilişkiyi incelemektir. Kardiyovasküler kalsifikasyonlar ile koroner arter hastalığı arasında ilişki olması durumunda, bu kalsifikasyonlar koroner aterosklerozun göstergesi olarak kullanılabilir. Çalışmaya koroner anjiyografi yapılan 1100 hasta alındı. Aort kapak kalsifikasyon varlığı ekokardiyografi ile değerlendirildi. Torasik aortadaki kalsifikasyonları saptamak için PA akciğer grafisi kullanıldı. Çalışmaya alınan 1100 hastanın 812'sinde (%73.8) koroner arter hastalığı saptanırken, 288'inde (%26.2) koronerler normal bulundu. Hastaların 420'sinde (38%) aort kapak kalsifikasyonu ve 180'inde (16%) torasik aorta plak kalsifikasyonu saptandı. Aort kapak kalsifikasyonu saptanan hastalarda, koroner arter hastalığı sıklığı (%88 karşı %65, p<0.0001) ve çok damar hastalığı oranı (%65% karşı %55, p=0.003) daha yüksek bulundu. Koroner arter hastalığı sıklığı ve çok damar hastalığı oranı, torasik aorta plak kalsifikasyonu saptanan hastalarda da yüksek bulundu (sırasıyla, %86 karşı %71, p<0.0001 ve %66 karşı %57, p=0.035). Logistik regresyon analizi ile koroner arter hastalığı risk faktörlerine göre düzeltme yapıldıktan sonra bile, aort kapak kalsifikasyonu (p=0.003) ve torasik aorta plak kalsifikasyonu (p=0.004), koroner arter hastalığı ile ilişkili bulundu. Aort kapak kalsifikasyonu olan hastalarda, torasik aorta plak kalsifikasyonu daha sık izlendi (%23% karşı. %12, p<0.0001). Sonuç olarak, çalşımamızda aort kapak kalsifikasyonu ve torasik aorta plak kalsifikasyonları ile koroner arter hastalığı arasında anlamlı ilişki saptadık. Ayrıca, aort kapak kalsifikasyonu ile torasik aorta plak kalsifikasyonu anlamlı olarak ilişkili idi. Kardiyovasküler kalsifikasyonların varlığı koroner arter hastalığı için bir gösterge olarak düşünülebilir.
The aim of this study was to determine whether there is a significant association between calcification of the aortic valve or thoracic aortic calcified plaques and coronary artery disease (CAD) in patients undergoing coronary angiography. If an association could be established between cardiovascular calcifications and CAD, their presence might be used as a marker of coronary atherosclerosis. The study group consisted of 1100 patients who underwent coronary angiography. The presence of aortic valve calcification was identified by echocardiography. Chest X-rays were used to detect calcification in the thoracic aorta. Of the 1100 patients included in the study, 812 (73.8 percent) had CAD, and 288 (26.2 percent) had normal coronary arteries. Aortic valve calcification was present in 420 (38%) and aortic calcified plaques in 180 (16%) of the entire study population. The patients with aortic valve calcification had a significantly higher prevalence of CAD (88% vs 65%, p<0.0001) and higher rates of multivessel disease (65% vs 55%, p=0.003). Also, the prevalence of CAD (86% vs 71%, p<0.0001) and multivessel disease (66% vs 57%, p=0.035) were significantly higher in patients with aortic calcified plaques compared with the patients without aortic calcified plaques. Logistic regression analysis showed that aortic valve calcification (p=0.003) and aortic calcified plaques (p=0.004) were strongly and significantly associated with CAD after adjusting for coronary risk factors. In addition, patients with aortic valve calcification had a high incidence of aortic calcified plaques (23% vs. 12%, p<0.0001). In conclusion, we found a significant association of CAD with the presence of aortic valve calcification and aortic calcified plaques. Our study further demonstrates that aortic valve calcification is significantly associated with calcified plaques in the thoracic aorta. Therefore, the presence of these calcifications should be regarded as a sign for the presence of CAD.
The aim of this study was to determine whether there is a significant association between calcification of the aortic valve or thoracic aortic calcified plaques and coronary artery disease (CAD) in patients undergoing coronary angiography. If an association could be established between cardiovascular calcifications and CAD, their presence might be used as a marker of coronary atherosclerosis. The study group consisted of 1100 patients who underwent coronary angiography. The presence of aortic valve calcification was identified by echocardiography. Chest X-rays were used to detect calcification in the thoracic aorta. Of the 1100 patients included in the study, 812 (73.8 percent) had CAD, and 288 (26.2 percent) had normal coronary arteries. Aortic valve calcification was present in 420 (38%) and aortic calcified plaques in 180 (16%) of the entire study population. The patients with aortic valve calcification had a significantly higher prevalence of CAD (88% vs 65%, p<0.0001) and higher rates of multivessel disease (65% vs 55%, p=0.003). Also, the prevalence of CAD (86% vs 71%, p<0.0001) and multivessel disease (66% vs 57%, p=0.035) were significantly higher in patients with aortic calcified plaques compared with the patients without aortic calcified plaques. Logistic regression analysis showed that aortic valve calcification (p=0.003) and aortic calcified plaques (p=0.004) were strongly and significantly associated with CAD after adjusting for coronary risk factors. In addition, patients with aortic valve calcification had a high incidence of aortic calcified plaques (23% vs. 12%, p<0.0001). In conclusion, we found a significant association of CAD with the presence of aortic valve calcification and aortic calcified plaques. Our study further demonstrates that aortic valve calcification is significantly associated with calcified plaques in the thoracic aorta. Therefore, the presence of these calcifications should be regarded as a sign for the presence of CAD.
Açıklama
Anahtar Kelimeler
Kalp ve Kalp Damar Sistemi
Kaynak
Türk Kardiyoloji Derneği Arşivi
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
32
Sayı
6
