SYNERGISTIC ACTIVITIES OF TWO PROPOLIS WITH AMPHOTERICIN B AGAINST SOME AZOLE-RESISTANT CANDIDA STRAINS. PART II

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dc.contributor.authorNizami, Duran
dc.contributor.authorMustafa, Muz
dc.contributor.authorGulbol, Duran Gulay
dc.contributor.authorBurcin, Ozer
dc.contributor.authorYusuf, Onlen
dc.date.accessioned2024-09-18T20:55:29Z
dc.date.available2024-09-18T20:55:29Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description3rd International Conference on Advanced Materials and Systems -- SEP 16-18, 2010 -- Bucharest, ROMANIAen_US
dc.description.abstractCandida strains are opportunistic pathogenic fungi in humans which can cause either septicaemic or mucosal infections. In this study, we aimed to investigate the existance of synergistic activities of two types of propolis (Hatay and Bursa) with Amphotericin B against some azole-resistant Candida strains. To evaluate cytotoxicity of propolis for human cells, the HEp-2 cell line (human larynx epidermoid carcinoma cell line) was used. The cytotoxicity of propolis samples was determined on a conventional haemocytometer using the trypan blue exclusion method. The synergystic activity of Hatay and Bursa propolis samples was assayed against four different azole-resistant Candida isolates (C. albicans, C. tropicalis, C. parapsilosis and C.glabrata). MIC values of Candida spp. were determined as described in the CLSI reference methods. The antifungal activities of a combination of this antifungal agent (Amphotericin B) were assessed by the checkerboard test and time-kill curve study. Bursa and Hatay propolis samples have remarkable antifungal activity against C.albicans, C.glabrata, C.tropicalis and C.parapsilosis. Also, the strong synergistic activity between Amphotericin B and propolis (especially Bursa propolis) was found against the azole resistant candida strains. Propolis may be an important prospect in the treatment of azole-resistant yeast. The effects of these two kinds of propolis against the Candida spp. in vitro are promising.en_US
dc.description.sponsorshipMinist Educ, Res, Youth and Sport,Natl Author Sci Res,Pielorex SA,Taro Ind,Class Shoe SRL,Nappaconf SRL,Salamandra Design SRL,LAura Fashion SRL,Prodstefano SRL,Hofigal Export Import SA,Muzeul Satului Dimitrie Gusti,A&A Vesa SRL,Picoma SA,Monuments & Tourist Heritage Admen_US
dc.identifier.endpage222en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11856
dc.identifier.wosWOS:000291667100036en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIncdtp-Icpien_US
dc.relation.ispartofProceedings of The 3rd International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropolisen_US
dc.subjectcandida strainsen_US
dc.subjectAmphotericin Ben_US
dc.titleSYNERGISTIC ACTIVITIES OF TWO PROPOLIS WITH AMPHOTERICIN B AGAINST SOME AZOLE-RESISTANT CANDIDA STRAINS. PART IIen_US
dc.typeConference Objecten_US

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