Plasma Apelin Levels and Thiol/Disulfide Balance in Patients with Type 2 Diabetes Mellitus

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dc.contributor.authorGunes, Umran Gezici
dc.contributor.authorTurgut, Faruk
dc.contributor.authorErdal, Huseyin
dc.contributor.authorDogan, Serdar
dc.date.accessioned2024-09-18T20:15:09Z
dc.date.available2024-09-18T20:15:09Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The main objective of this research is to investigate the relationship between the plasma apelin concentrations, oxidative stress biomarkers (dynamic thiol/disulfide balance), and albuminuria in patients with type 2 diabetes mellitus. Methods: The study was carried out with 87 patients with type 2 diabetes mellitus and 24 age- and sex-matched healthy control group. Serum apelin concentrations were studied using the enzyme-linked immunosorbent assay method. Colorimetric method was used to determine native and total thiol levels. Concentrations of spot urine albumin and creatinine were measured to calculate the albumin creatinine ratio (mg/g). Results: Serum apelin concentrations were significantly lower in patients with type 2 diabetes mellitus compared to the control group (P <.001). Native and total thiol ratios were also significantly lower in diabetic patients compared to healthy patients (P <.001). The calculated disulfide levels of the patients and control groups were similar (P =.182). A negative and osignificant correlation was detected between serum apelin concentrations, and glucose and hemoglobin A1c levels in diabetic patients (r = -0.272, P =.004, r = -0.280, P =.003, respectively). A negative and significant correlation was also observed between native and total thiol levels and albumin (r = -0.338, P =.001, r = -0.328, P =.001, respectively). Conclusion: We found significantly lowered serum apelin concentrations and native and total thiol levels in patients with type 2 diabetes mellitus. An association was also observed between serum apelin concentrations and glycemic control. The role of apelin and thiol/disulfide balance in diabetic kidney disease requires more detailed studies.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Coordination Office of Scientific Research Projects [2019/14]en_US
dc.description.sponsorshipThis research was supported by Hatay Mustafa Kemal University Coordination Office of Scientific Research Projects (Project # 2019/14).en_US
dc.identifier.doi10.5152/turkjnephrol.2023.2172107
dc.identifier.endpage208en_US
dc.identifier.issn2667-4440
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85167709959en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage203en_US
dc.identifier.trdizinid1188663en_US
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2023.2172107
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188663
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9477
dc.identifier.volume32en_US
dc.identifier.wosWOS:001034452400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectoxidative stressen_US
dc.subjectdynamic thiol/disulfide balanceen_US
dc.subjectapelinen_US
dc.subjectdiabetic kidney diseaseen_US
dc.subjectalbuminuriaen_US
dc.titlePlasma Apelin Levels and Thiol/Disulfide Balance in Patients with Type 2 Diabetes Mellitusen_US
dc.typeArticleen_US

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