Investigating of Effects of Metformin on Melanoma Skin Cancer
dc.contributor.author | Alp, Harun | |
dc.contributor.author | Tutun, Hidayet | |
dc.contributor.author | Altıntaş, Levent | |
dc.contributor.author | Kaplan, Halil Mahir | |
dc.contributor.author | Şingirik, Ergin | |
dc.contributor.author | Kahraman, İbrahim | |
dc.date.accessioned | 2024-09-19T16:28:08Z | |
dc.date.available | 2024-09-19T16:28:08Z | |
dc.date.issued | 2021 | |
dc.department | Hatay Mustafa Kemal Üniversitesi | en_US |
dc.description.abstract | Aim: Apoptotic pathways are important for resistance to chemotherapeutics drugs and cancer development. Metformin is a safe, inexpensive and effective drugused to treat type 2 diabetes. Furthermore, although there is evidence of anticancer effects, the mechanisms by which metformin exerts the effects are unclear.Therefore, it was aimed to investigate Bcl-2, kaspaz-3, bax, wee-1, AIF, grp78 and gadd153 levels in metformin treated skin cancer cells. Materials and Methods: The skin cancer cells (B16F10) were treated with metformin and kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF levels were analyzedby using ELISA. Result: Treatment of metformin increased of proapoptotic proteins (kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF) and decreased antiapoptotic protein (bcl 2). Conclusion: In conclusion, this study showed that metformin has apoptotic effect on melanoma skin cancer. | en_US |
dc.identifier.endpage | 115 | en_US |
dc.identifier.issn | 2602-3741 | |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 111 | en_US |
dc.identifier.trdizinid | 465205 | en_US |
dc.identifier.uri | https://search.trdizin.gov.tr/tr/yayin/detay/465205 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12483/16524 | |
dc.identifier.volume | 31 | en_US |
dc.indekslendigikaynak | TR-Dizin | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Genel Tıp Dergisi | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Investigating of Effects of Metformin on Melanoma Skin Cancer | en_US |
dc.type | Article | en_US |
Dosyalar
Orijinal paket
1 - 1 / 1
Yükleniyor...
- İsim:
- 16524.pdf
- Boyut:
- 651.15 KB
- Biçim:
- Adobe Portable Document Format
- Açıklama:
- Tam Metin / Full Text