Investigating of Effects of Metformin on Melanoma Skin Cancer

dc.contributor.authorAlp, Harun
dc.contributor.authorTutun, Hidayet
dc.contributor.authorAltıntaş, Levent
dc.contributor.authorKaplan, Halil Mahir
dc.contributor.authorŞingirik, Ergin
dc.contributor.authorKahraman, İbrahim
dc.date.accessioned2024-09-19T16:28:08Z
dc.date.available2024-09-19T16:28:08Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Apoptotic pathways are important for resistance to chemotherapeutics drugs and cancer development. Metformin is a safe, inexpensive and effective drugused to treat type 2 diabetes. Furthermore, although there is evidence of anticancer effects, the mechanisms by which metformin exerts the effects are unclear.Therefore, it was aimed to investigate Bcl-2, kaspaz-3, bax, wee-1, AIF, grp78 and gadd153 levels in metformin treated skin cancer cells. Materials and Methods: The skin cancer cells (B16F10) were treated with metformin and kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF levels were analyzedby using ELISA. Result: Treatment of metformin increased of proapoptotic proteins (kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF) and decreased antiapoptotic protein (bcl 2). Conclusion: In conclusion, this study showed that metformin has apoptotic effect on melanoma skin cancer.en_US
dc.identifier.endpage115en_US
dc.identifier.issn2602-3741
dc.identifier.issue2en_US
dc.identifier.startpage111en_US
dc.identifier.trdizinid465205en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/465205
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16524
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGenel Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigating of Effects of Metformin on Melanoma Skin Canceren_US
dc.typeArticleen_US

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