Chemiresistive CuO sensors for label-free C-reactive protein detection

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dc.contributor.authorBayansal, Fatih
dc.contributor.authorCetinkara, Haci Ali
dc.date.accessioned2024-09-18T20:08:14Z
dc.date.available2024-09-18T20:08:14Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, we developed fast and highly sensitive, label-free Ca-doped cupric oxide (CuO) based che-miresistive biosensors to detect C-reactive protein (CRP). The Successive Ionic Layer Adsorption and Reaction (SILAR) method was used to deposit pure and Ca-doped CuO thin films on interdigitated gold electrodes. Film surfaces were functionalized with monoclonal anti-C-reactive protein antibody (anti-CRP) by random physisorption method. Sensor fabrication steps were monitored using the linear sweep vol-tammetry method. Scanning electron microscopy was used to investigate the surface morphology. Energy-dispersive X-ray spectroscopy was used to determine the elemental composition. The structure of the films was investigated by the powder X-ray diffractometry method. Sensor parameters were determined by the change in sensor resistance over time. The sensors showed a good response to CRP with a linear detection range of 0.1-5.0 pg/ml, which was within the clinically significant range. Detection limits of 49.61 and 48.81 ng/ml were estimated using the standard deviation of the y-intercept and the standard deviation of the regression line, respectively. Dynamic response times of all fabricated sensors were found to be less than 30 s (c) 2022 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Office [1201 D 0101]en_US
dc.description.sponsorshipThe research was funded by Mustafa Kemal University Scientific Research Project Office (Project No: 1201 D 0101) .en_US
dc.identifier.doi10.1016/j.jallcom.2022.166737
dc.identifier.issn0925-8388
dc.identifier.issn1873-4669
dc.identifier.scopus2-s2.0-85136519439en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jallcom.2022.166737
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8721
dc.identifier.volume926en_US
dc.identifier.wosWOS:000854502300003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Alloys and Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChemiresistoren_US
dc.subjectBiosensorsen_US
dc.subjectC-reactive proteinen_US
dc.subjectLabel -free detectionen_US
dc.subjectCuO thin filmen_US
dc.subjectLinear sweep voltammetryen_US
dc.titleChemiresistive CuO sensors for label-free C-reactive protein detectionen_US
dc.typeArticleen_US

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