Spectral classical least square calibration approach for the simultaneous determination and stability test of Sulphadiazme and Trimethoprim in bolus
[ N/A ]
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A simple spectral classical least square calibration approach were proposed for the simultaneous quantitative evaluation and stability testing of sulphadiazine and trunethoprun in an animal commercial preparation, bolus without requiring a priory separation step. Stability tests of sulphadiazine and trimethoprim in bolus were performed by using the following conditions: Room temperature, refrigerator and etuve (37oC) for each 3 month during 12 months. A spectral classical least square calibration based on the use of absorptivities at three-wavelength set (241, 257 and 288 run) was computed by using the linear concentration range of 4.0-22.0 ug mL-1 for sulphadiazine and 3.0-18.0 jug mL-1 for trimethoprim. The proposed spectral least square calibration was validated by using various synthetic binary mixtures containing the above veterinary drugs. Simultaneous analysis and stability test of sulphadiazine and trunethoprun in commercial veterinary bolus was established by the spectral classical calibration method. © Medwell Journals, 2010.
Açıklama
Anahtar Kelimeler
Chemometry, Simultaneous determination, Spectral classical least square, Stability test, Sulphadiazine, Trimethoprim
Kaynak
Journal of Animal and Veterinary Advances
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
9
Sayı
4
