The effect of oral baclofen and botulinum toxin treatments in hemiplegic spasticity on the nociceptive flexor reflex: A randomized clinical trial

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dc.contributor.authorGunturk, Erturk
dc.contributor.authorOgut, Halil
dc.contributor.authorGuler, Hayal
dc.contributor.authorTurhanoglu, Ayse Dicle
dc.date.accessioned2024-09-18T20:02:50Z
dc.date.available2024-09-18T20:02:50Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: This study aimed to analyze the effect of oral baclofen treatment and botulinum toxin type A (BT-A) injection treatment in hemiplegic patients with spasticity on the electromyographic nociceptive flexor reflex (NFR) threshold. Patients and methods: A total of 29 spastic hemiplegic patients (20 males, 9 females; mean age: 52.9 +/- 10.1; range, 27 to 64) with Modified Ashworth Scale (MAS) grades 2-4 were included in the prospective, randomized study between May 2018 and March 2019. The patients were divided into two groups: the BT-A group consisted of 15 patients that underwent a BT-A injection and the baclofen group consisted of 14 patients treated with baclofen. Modified Ashworth Scale, Visual Analog Scale (VAS), Barthel daily life activity index, and NFR threshold values were used in the evaluation of the patients before and after the treatment at the sixth week. The motor evaluation of the patients was performed using Brunnstrom motor staging. Results: In both groups, MAS and VAS values decreased significantly compared to pretreatment (p<0.05). There was a significant decrease in ankle MAS score (p<0.001) and a significant increase in Brunnstrom hand recovery stages in the BT-A group compared to pretreatment (p=0.020). While the NFR threshold statistically significantly increased in the baclofen group compared to pretreatment (p=0.007), there was no significant change in the BT-A group (p=0.669). Conclusion: These results suggest that BT-A injections do not cause a significant change in the NFR threshold in the treatment of spasticity.en_US
dc.identifier.doi10.5606/tftrd.2022.9596
dc.identifier.endpage531en_US
dc.identifier.issn2587-1250
dc.identifier.issue4en_US
dc.identifier.pmid36589348en_US
dc.identifier.scopus2-s2.0-85146527023en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage524en_US
dc.identifier.trdizinid1170815en_US
dc.identifier.urihttps://doi.org/10.5606/tftrd.2022.9596
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1170815
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8053
dc.identifier.volume68en_US
dc.identifier.wosWOS:000898445300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurkish Journal of Physical Medicine and Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBaclofenen_US
dc.subjectbotulinum toxin type Aen_US
dc.subjectelectromyographyen_US
dc.subjectspasticityen_US
dc.subjectstrokeen_US
dc.titleThe effect of oral baclofen and botulinum toxin treatments in hemiplegic spasticity on the nociceptive flexor reflex: A randomized clinical trialen_US
dc.typeArticleen_US

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