Factors associated with frequency and severity of COVID-19 in patients with axial spondyloarthritis

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dc.contributor.authorPekdiker, Mete
dc.contributor.authorKara, Mete
dc.contributor.authorKoç, Emrah
dc.contributor.authorKimyon, Gezmiş
dc.date.accessioned2024-09-19T16:23:35Z
dc.date.available2024-09-19T16:23:35Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in managing rheumatic diseases during the pandemic; therefore, we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis (axSpa) in this study. Materials and methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa-associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5% of them had ankylosing spondylitis, 35.5% had non-radiographic axSpa, and 59.4% of patients were treated with a biologic agent. The frequency of COVID-19 was 23% (n:192); only five patients (0.5%) had a history of intensive care unit. Advanced age, hypertension (HT), and diabetes mellitus (DM) were found to be significantly more common in those with involvement in high-resolution computed tomography (HRCT) (p:0.02, p:0.01, and p<0.001). In hospitalized individuals, female gender, HT, DM, and disease lasting longer than 10 years were significantly higher (p:0.03, p:0.011, p<0.001, and p:0.014). Only DM was found as an independent risk factor for both pulmonary involvement in HRCT (p:0.029) and hospitalization (p:0.001). Conclusion: We conducted our study with a homogenous study population and our results suggested that biological agents did not affect poor COVID-19 outcomes; only DM was associated with a more severe COVID-19 course in patients with axSpa.en_US
dc.identifier.doi10.31362/patd.1223660
dc.identifier.endpage411en_US
dc.identifier.issn1309-9833
dc.identifier.issn1308-0865
dc.identifier.issue3en_US
dc.identifier.startpage404en_US
dc.identifier.trdizinid1193063en_US
dc.identifier.urihttps://doi.org/10.31362/patd.1223660
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1193063
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15986
dc.identifier.volume16en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofPamukkale Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectaxial spondyloarthritisen_US
dc.subjectankylosing spondylitisen_US
dc.subjectnon-radiographic axial spondyloarthritisen_US
dc.subjectdiabetes mellitusen_US
dc.titleFactors associated with frequency and severity of COVID-19 in patients with axial spondyloarthritisen_US
dc.typeArticleen_US

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