Comparison of renal lesions in cats and dogs using pathomorphological and immunohistochemical methods
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Date
2019
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
We investigated the pathogenesis of chronic renal fibrosis in cats and dogs using immunohistochemistry. We used the avidin-biotin complex peroxidase (ABC-P) method with antibodies against transforming growth factor-beta 1, cytokeratin, E-cadherin, S100A4, alpha-smooth muscle actin, vimentin and nestin to determine whether tubule epithelial cells had undergone epithelial-mesenchymal transformation (EMT) that resulted in loss of epithelial cells and an increased number of mesenchymal cells. Although nephrosis was more common in dogs, nephritis was more common in cats; these pathologies developed in both kidneys. We found that EMT participated in the pathogenesis of renal fibrosis in both dogs and cats.
Description
Keywords
Chronic disease, epithelial-mesenchymal transformation, fibrosis, kidney, nephritis, nephrosis
Journal or Series
Biotechnic & Histochemistry
WoS Q Value
Q4
Scopus Q Value
Q2
Volume
94
Issue
2
