Comparison of renal lesions in cats and dogs using pathomorphological and immunohistochemical methods

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dc.contributor.authorKutlu, Tuncer
dc.contributor.authorAlcigir, Gunay
dc.date.accessioned2024-09-18T20:08:24Z
dc.date.available2024-09-18T20:08:24Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe investigated the pathogenesis of chronic renal fibrosis in cats and dogs using immunohistochemistry. We used the avidin-biotin complex peroxidase (ABC-P) method with antibodies against transforming growth factor-beta 1, cytokeratin, E-cadherin, S100A4, alpha-smooth muscle actin, vimentin and nestin to determine whether tubule epithelial cells had undergone epithelial-mesenchymal transformation (EMT) that resulted in loss of epithelial cells and an increased number of mesenchymal cells. Although nephrosis was more common in dogs, nephritis was more common in cats; these pathologies developed in both kidneys. We found that EMT participated in the pathogenesis of renal fibrosis in both dogs and cats.en_US
dc.description.sponsorshipAnkara University oYP (Teaching Staff Training Program) Officeen_US
dc.description.sponsorshipThis study was performed for the PhD thesis of the first author. The thesis study was financed by Ankara University oYP (Teaching Staff Training Program) Office.en_US
dc.identifier.doi10.1080/10520295.2018.1522670
dc.identifier.endpage133en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid30328730en_US
dc.identifier.scopus2-s2.0-85055192483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1522670
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8815
dc.identifier.volume94en_US
dc.identifier.wosWOS:000467970800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic diseaseen_US
dc.subjectepithelial-mesenchymal transformationen_US
dc.subjectfibrosisen_US
dc.subjectkidneyen_US
dc.subjectnephritisen_US
dc.subjectnephrosisen_US
dc.titleComparison of renal lesions in cats and dogs using pathomorphological and immunohistochemical methodsen_US
dc.typeArticleen_US

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