Oxidative stress index can be a new marker related to disease severity in COVID-19

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dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.contributor.authorDogan, Serdar
dc.contributor.authorBal, Tayibe
dc.contributor.authorCabalak, Mehmet
dc.contributor.authorDikmen, Nursel
dc.contributor.authorYaqoobi, Hasibullah
dc.contributor.authorOzcan, Oguzhan
dc.date.accessioned2024-09-18T20:13:27Z
dc.date.available2024-09-18T20:13:27Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to evaluate the relationship between systemic oxidative balance, and the severity of the disease in patients with COVID 19. Methods: Sixty-four patients were divided into three groups according to the severity of the disease: mild (n=28), moderate (n=11) and severe (n=25). Twenty-four healthy controls included to the study. Proinflammatory cytokines (IL-6 and TNF-alpha), D-dimer, fibrinogen, total oxidative status (TOS), total antioxidant status (TAS) were measured and oxidative stress index (OSI) was calculated. Results: The mean age of severe group was significantly higher than the other groups (p=0.001). TAS levels were significantly decreased in all patient groups compared to controls, while serum TOS and OSI levels were significantly different in all three stages of the disease. Serum IL-6 and TNF-alpha levels were significantly elevated in severe group compared to other groups. TOS and OSI levels were also significantly correlated with IL-6, CRP, ferritin, fibrinogen, LDH and D-dimer. Conclusions: TOS and OSI levels are an indicator of systemic oxidative balance in COVID-19 and related to the disease severity. They can be an important marker for evaluating the disease severity and used in the management of patients with COVID-19.en_US
dc.identifier.doi10.1515/tjb-2021-0013
dc.identifier.endpage357en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85116262428en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage349en_US
dc.identifier.trdizinid492739en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0013
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/492739
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9194
dc.identifier.volume46en_US
dc.identifier.wosWOS:000693607700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectIL-6en_US
dc.subjectOSIen_US
dc.subjectoxidative stressen_US
dc.subjectTOSen_US
dc.titleOxidative stress index can be a new marker related to disease severity in COVID-19en_US
dc.typeArticleen_US

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