Investigation of the effects of lipoic acid and dihydrolipoate on experimental renal ischemia-reperfusion model

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dc.contributor.authorKaçmaz, Filiz
dc.contributor.authorÖzcan, Oğuzhan
dc.contributor.authorArpacı, Abdullah
dc.contributor.authorAyaz, Ercan
dc.contributor.authorBayraktar, Hamdullah Suphi
dc.contributor.authorGörür, Sadık
dc.date.accessioned2024-09-19T16:22:08Z
dc.date.available2024-09-19T16:22:08Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Ischemic/reperfusion (I/R) causes tissue injury and the leading cause of acute kidney injury. In this study, we aimed to investigate the effects of the long and short-term usage of ALA and short-term DHLA on oxidative stress markers in the experimental renal ischemia-reperfusion model. Method: Forty male rats (250 to 300 gr) were divided into 5 groups: control; I/R group; long-term ALA+IR group; short-term ALA+IR group; and short-term DHLA+IR group. Ischemia was carried out for 45 minutes followed by reperfusion for 4 hours. Thiobarbituric acid reactive sunstances (TBARM), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in tissue samples and serum total antioxidant status (TAS) and total oxidative stress (TOS) assayed by the spectrophotometrically. Tissue samples were investigated by histopathological analyzes. Results: TBARM (Control: 0.38±0.05. I/R: 1.37±0.17, long-term ALA-treated group:1.025±0.15, short-term ALA-treated group: 0.68±0.09, short-term DHLA- treated group: 0.38±0.04 (nmol/mg protein); p<0,001) CAT (Control: 0.12±0.02, I/R: 0.04±0.008, long-term ALA-treated group: 0.07±0.01, short-term ALA- treated group:0.06±0.008, short-term DHLA-treated group: 0.08±0.01 (k/mg protein); p<0.001), GSH-Px (Control: 0.45±0.04, I/R: 0.21±0.028, long-term ALA- treated group: 0.37±0.05, short-term ALA-treated group :0.34±0.05, short-term DHLA-treated group: 0.37±0.04 (U/mg protein); p<0.001), and serum OSI levels (Control: 1.32±0.15, I/R: 3.08±0.44, long-term ALA-treated group: 1.775±0.21, short-term ALA-treated group: 1.85±0.37, short-term DHLA-treated group: 1.53±0.21 (arbitrary unit) ; p<0.001) were improved in the long and short-term ALA-treated group and short-term DHLA-treated group compared to the I/R group. These findings were more prominent in histopathological tissue samples in the DHLA-treated group. Conclusion: We consider that both long-term and short-term ALA applications have the potential for the treatment of renal I/R damage. Besides, DHLA is more effective than ALA.en_US
dc.identifier.doi10.17944/mkutfd.1012649
dc.identifier.endpage195en_US
dc.identifier.issn2149-3103
dc.identifier.issue46en_US
dc.identifier.startpage187en_US
dc.identifier.trdizinid1109179en_US
dc.identifier.urihttps://doi.org/10.17944/mkutfd.1012649
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1109179
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15635
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMustafa Kemal Üniversitesi Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemic Damageen_US
dc.subjectReperfusionen_US
dc.subjectLipoic Aciden_US
dc.subjectDihydrolipoaten_US
dc.subjectAntioxidant Enzymeen_US
dc.titleInvestigation of the effects of lipoic acid and dihydrolipoate on experimental renal ischemia-reperfusion modelen_US
dc.typeArticleen_US

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