Effects of Food Restriction on PTGS2 and NRF2 Genes Expression Levels in Rat Testis

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dc.contributor.authorÖzkan, Hüseyin
dc.contributor.authorDalkıran, Sevda
dc.contributor.authorKaraaslan, İrem
dc.contributor.authorKaya, Ufuk
dc.contributor.authorAlakuş, İbrahim
dc.contributor.authorÇamdeviren, Baran
dc.contributor.authorYakan, Akın
dc.date.accessioned2024-09-19T16:23:39Z
dc.date.available2024-09-19T16:23:39Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effects of food restriction on oxidative status at the molecular levels of the testis in rats. A total of 16 male Wistar rats were allocated to two groups (n=8) and fed for four weeks. The first group was control (Cont) and consumed food and water ad libitum. The second one, food-restricted group (FR) was presented half of the regular consumption. But the water was presented ad libitum. The feeding period was maintained for four weeks. At the end of the feeding period, rats were euthanized by cardiac blood sampling under anesthesia. Malondialdehyde (MDA) levels in testis tissue were determined and calculated as nmol/mg protein. In addition, Prosta-glandin-Endoperoxide Synthase 2 (PTGS2) and Nuclear factor erythroid 2–related factor 2 (NRF2) genes expression levels were determined in testis tissue. While MDA and gene expression levels were found similar in groups, a positive correlation was found between PTGS2 and NRF2 genes (r=0.629; P<0.05). The molecular regulation of oxidative sta-tus was found strongly related with PTGS2 and NRF2 genes molecular activity in testis of rats. The obtained results were shown that the feeding period and restriction rate factors were mainly responsible for the oxidative status of testis tissue.en_US
dc.identifier.doi10.32707/ercivet.1142609
dc.identifier.endpage128en_US
dc.identifier.issn1304-7280
dc.identifier.issn2267-5498
dc.identifier.issue2en_US
dc.identifier.startpage123en_US
dc.identifier.trdizinid1107107en_US
dc.identifier.urihttps://doi.org/10.32707/ercivet.1142609
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1107107
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16029
dc.identifier.volume19en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErciyes Üniversitesi Veteriner Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectPTGS2en_US
dc.subjecttestisen_US
dc.subjectFood restrictionen_US
dc.subjectNRF2en_US
dc.titleEffects of Food Restriction on PTGS2 and NRF2 Genes Expression Levels in Rat Testisen_US
dc.typeArticleen_US

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