Meme tümörlü köpeklerde kandaki OMEGA-3 ve OMEGA-6 düzeylerinin klinik önemi
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Date
2019
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Hatay Mustafa Kemal Üniversitesi
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info:eu-repo/semantics/openAccess
Abstract
Çalışma, köpeklerde meme tümörlerinin etiyolojisinde önemli bir yeri olan omega yağ asitlerinin, sağlıklı ve meme tümörü olan köpeklerde kandaki düzeylerinin belirlenmesi amacıyla düzenlendi. Çalışma klinik olarak meme tümörü tanısı konulan 9 dişi köpek ile klinik olarak sağlıklı 8 dişi köpekte gerçekleştirildi. Klinik olarak meme tümörü tanısı konulan köpeklerden operasyona alınmadan önce antikoagülanlı tüplere 10 ml kan örneği alındı ve kan örnekleri omega yağ asitleri analizleri yapılıncaya kadar -20○C'de muhafaza edildi. Klinik olarak sağlıklı olan köpeklerden de antikoagülanlı tüplere yaklaşık 10 ml kan örneği alındı ve kan örnekleri omega yağ asitleri analizleri yapılıncaya kadar -20○C'de muhafaza edildi. Tümör şüpheli kitleler mastektomi operasyonu ile uzaklaştırıldı ve histopatolojik inceleme amacıyla laboratuvara gönderildi. Histopatolojik tanı sonuçlarına göre 9 dokunun da malign meme tümörü olduğu tespit edildi. Omega yağ asitleri analizleri sonucunda, omega-3 seviyesinin sağlıklı köpeklerde yüksek olduğu (p<0.001), omega-6 seviyesinin ise meme tümörlü köpeklerde yüksek olduğu (p<0.001) belirlendi. Sonuç olarak meme tümörlerinde koruyucu etkiye sahip olan omega-3 seviyesinin sağlıklı köpeklerin kanlarında daha yüksek olmasına (p<0.001), meme tümörü riskini ve hastalığın ilerlemesini artıran omega-6 seviyesinin ise meme tümörlü köpeklerde daha yüksek seviyede (p<0.001) belirlenmesine bağlı olarak, omega yağ asitlerinin köpeklerde meme tümörünün biyolojik mekanizmasında önemli bir etken olduğu kanısına varıldı.
The study was designed to determine the blood levels of omega fatty acids, which have an important role in the etiology of mammary tumors in dogs, in healthy and mammary tumor dogs. The study was carried out in 9 clinically mammary tumor diagnosed and 8 healthy female dogs. 10 ml blood samples were taken from anticoagulant tubes before the operation of dogs diagnosed clinically as mammary tumors and blood samples were kept at -20°C until analysis of omega fatty acids. Approximately 10 ml of blood samples were taken from clinically healthy dogs and anticoagulant tubes and blood samples were kept at -20°C until analysis of omega fatty acids. Tumor suspicious masses were removed by mastectomy and sent to the laboratory for histopathological examination. According to histopathological diagnosis results, 9 tissues were found to be malignant mammary tumors. Omega-3 levels were found to be high in healthy dogs (p<0.001) and omega-6 levels were higher in dogs with mammary (p<0.001). As a result, omega-3 level which has protective effect on mammary tumors is higher in the blood of healthy dogs (p<0.001), and omega-6 level which increases mammary tumor risk and disease progression is higher in dogs with mammary tumor (p<0.001). It is concluded that omega fatty acids are an important factor in the biological mechanism of mammary tumor in dogs.
The study was designed to determine the blood levels of omega fatty acids, which have an important role in the etiology of mammary tumors in dogs, in healthy and mammary tumor dogs. The study was carried out in 9 clinically mammary tumor diagnosed and 8 healthy female dogs. 10 ml blood samples were taken from anticoagulant tubes before the operation of dogs diagnosed clinically as mammary tumors and blood samples were kept at -20°C until analysis of omega fatty acids. Approximately 10 ml of blood samples were taken from clinically healthy dogs and anticoagulant tubes and blood samples were kept at -20°C until analysis of omega fatty acids. Tumor suspicious masses were removed by mastectomy and sent to the laboratory for histopathological examination. According to histopathological diagnosis results, 9 tissues were found to be malignant mammary tumors. Omega-3 levels were found to be high in healthy dogs (p<0.001) and omega-6 levels were higher in dogs with mammary (p<0.001). As a result, omega-3 level which has protective effect on mammary tumors is higher in the blood of healthy dogs (p<0.001), and omega-6 level which increases mammary tumor risk and disease progression is higher in dogs with mammary tumor (p<0.001). It is concluded that omega fatty acids are an important factor in the biological mechanism of mammary tumor in dogs.
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Keywords
Veteriner Hekimliği, Veterinary Medicine
