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Öğe Acute 'upside-down' visual inversion due to multiple sclerosis(Sage Publications Ltd, 2008) Okuyucu, Esra Emine; Okuyucu, Semsettin; Karazincir, Sinem; Akoglu, Ertap; Duman, TaskinIn a 20- year- old male patient, a 180 degree inversion of visual image was found as a manifestation of multiple sclerosis. Upside down reversal of vision is not a well- known sign in multiple sclerosis. Exact mechanism is still unknown. Lesions involving cortical areas, mainly the parieto- occipital region, have occasionally been documented. To our knowledge this is the first report of upside- down reversal of vision in multiple sclerosis with cerebra lesion on MRI.Öğe Calcium Homeostasis During Attack and Remission in Patients With Idiopathic Benign Paroxysmal Positional Vertigo(Lippincott Williams & Wilkins, 2016) Kahraman, Serif Samil; Ozcan, Oguzhan; Arli, Cengiz; Ustun, Ihsan; Erduran, Rana; Akoglu, Ertap; Gokce, CumaliObjective:To evaluate changes in calcium metabolism in patients with idiopathic benign paroxysmal positional vertigo (BPPV) on initial presentation and at the follow-up visit.Subjects and Methods:The study comprised a total of 31 patients aged greater than 18 years who presented at the otorhinolaryngology outpatient clinic of our hospital, newly diagnosed as idiopathic BPPV based on the history compatible with BPPV and positive provocative maneuver (either Dix-Hallpike or Roll test). The first blood sample was obtained on the day of initial presentation when the patient was found to have active unilateral BPPV. After 6 months, a blood sample was again drawn in accordance with the procedure. Blood samples were analyzed for data on 25-hydroxyvitamin D (25(OH)-D), total calcium, parathormone and ionized calcium on initial presentation, and at the follow-up visit.Results:The patients comprised 20 (64.5%) women and 11 (35.5%) men with a mean age of 49.78 years (range, 23-75 years). During an attack a higher prevalence of decreased serum Vitamin D is less than 20ng/ml, was determined (93.5% versus 38.7%). There were statistical differences between the Vitamin D values, parathormone, and corrected by pH ionized calcium in both periods (p<0.05).Conclusion:A statistically significant association was determined between Vitamin D and calcium metabolism in patients with idiopathic BPPV. It can be considered that Vitamin D deficiency and decreased ionized Ca level may be a risk for BPPV, not only in patients with osteoporosis but also in all patients. Very low levels of 25(OH)-D seem to be associated with recurrence of BPPV. The recurrences might possibly be prevented with supplementary Vitamin D especially in those with recurrent idiopathic BPPV but further studies would be necessary to determine this.Öğe Comparison of Mean Platelet Volume Values between Patients with Nasal Polyp and Healthy Individuals(Galenos Yayincilik, 2013) Cevik, Cengiz; Yengil, Erhan; Akbay, Ercan; Arli, Cengiz; Gulmez, Mehmet Ihsan; Akoglu, ErtapObjective: Nasal Polyp (NP) and Allergic Rhinitis (AR) are frequently seen in common. It has been reported that there is an increase in the risk of atherosclerosis in allergic patients. In our study, we aimed to evaluate Mean Platelet Volume (MPV) values in patients with NP, which is used as a marker of atherosclerosis. Methods: Seventy-five patients who underwent functional endoscopic sinus surgery (FESS) with a diagnosis of NP were reviewed. Seventy-five age-matched healthy individuals without AR made up the control group. Val-ues of white blood cell (WBC), platelet (PLT), hemoglobilin (Hb) and MPV were evaluated. Results: MPV values were found to be low in patients with NP 7.89 +/- 1.02 fL compared to control group 8.32 +/- 1.42 fL. This finding was statistically significant. Conclusion: It was found that MPV values are significantly low in patients with NP than control group.Öğe Comparison of the result of consolidative technique otoplasty and incisionless otoplasty in the repairs of prominent ears(Springer, 2016) Temel, Metin; Kahraman, S. Samil; Berber, Ozge; Cevik, Cengiz; Akoglu, ErtapWe aimed to compare the long-term results of complications of consolidative technique otoplasty (CTO) and incisionless otoplasty (IO). The study consists of 156 patients who were operated between 2006 and 2015. According to surgical techniques, these patients were divided into two groups as IO group and CTO group. The distance between the head and the ear was assessed by measuring the four points preoperatively and postoperatively (SUP: most superior helical point, SCA: superior conchal attachment, ICA: inferior conchal attachment, and lobule). Early and late postoperative complications, operative time were recorded. 128 ears in IO group, 163 ears in CTO group were prominent. When postoperative SUP, SCA, ICA, lobule values for right and left ears in both groups were statistically evaluated, it was found that CTO technique has led to significantly greater improvement compared to the IO technique (p < 0.001). The success rate in IO technique and CTO technique was 72 and 96 %, respectively. Early complications were similar in both groups. The late period complication determined much more frequently was seen in the IO group. Concerning operative time, it was identified as significantly lower in the IO group (p < 0.001). The early-term outcomes of both techniques were similar; however, the complication rates due to suture material and needed for revision in IO technique were higher whereas CTO technique was more permanent with lower complication risks.Öğe Concha bullosa pyocele(Springer, 2008) Okuyucu, Emsettin; Akoglu, Ertap; Dagli, Ali SafakAn aerated middle turbinate is called a concha bullosa (CB), and given the importance of the middle turbinate in nasal physiology, variations that alter the airflow and mucous drainage can cause sinonasal symptoms. A pyocele of the middle turbinate differs from an infected CB because it has the potential to expand and destroy neighbouring tissues like a tumour. We present a concha bullosa pyocele (CBP) that expanded against the lamina papyracea without causing orbital displacement. As pus was discharged whilst performing an endoscopic biopsy to determine whether it was neoplastic, the lateral aspect of the turbinate was excised to complete the procedure.Öğe Dimensions of internal jugular veins in Turkish children aged between 0 and 6 years in resting state and during Valsalva maneuver(Elsevier Ireland Ltd, 2007) Karazincir, Sinem; Akoglu, Ertap; Balcı, Ali; Sangun, Ozlem; Okuyucu, Semsettin; Ozbakis, Cagla; Karazincir, OlgunObjective: We aimed to establish the values of the internal jugular vein (IJV) sizes in Turkish children aged between 0 and 6 years. Methods: Ninety-four normal children included in this study. All of the children were imaged by ultrasonography (USG) at the level of the cricoid cartilage. The maximal antero-posterior (AP) and transverse (T) diameters of the IJV were measured during regular breathing and Valsalva maneuver. Results: The mean transverse diameter of the right and left IJV were 8.11 +/- 3.01 and 7.64 +/- 2.68 mm in resting state. These values changed to 12.57 +/- 4.34 and 10.82 +/- 3.80 mm in Valsalva state, respectively. The AP diameters were found to be 5.43 +/- 2.07 for the right and 5.86 +/- 4.53 mm for the left IJV at rest. During VM, these values changed to 8.70 +/- 2.40 and 8.30 +/- 2.90 mm for the right and left IJV, respectively. There was no significant difference on the evaluation of the relationship between the right and left diameters of the IJV. While there were significant differences in sizes between the resting and Valsalva states. Also, the T diameter of the right IJV during Valsalva state was greater than those of the left. There were significant correlations between the diameters of the IJV and the age, weight and height of the children. Conclusion: The results we obtained in this study may be important in an attempt of intravascular intervention to IJV. These values may also be important for the comparison with the IJV sizes of the patients who have phlebectasia. (c) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis(Elsevier Ireland Ltd, 2006) Akoglu, Ertap; Goeruer, Sadik; Atik, Esin; Okuyucu, Semsettin; Sanguen, OezlemObjective: To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis. Methods: Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray. Results: No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy. Conclusion: Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time. (C) 2006 Elsevier Ireland Ltd. Atl. rights reserved.Öğe The effect of anesthetic agents on perioperative bleeding during tonsillectomy: Propofol-based versus desflurane-based anesthesia(Mosby-Elsevier, 2008) Okuyucu, Semsettin; Inanoglu, Kerem; Akkurt, Cagla Ozbakis; Akoglu, Ertap; Dagli, SafakOBJECTIVE: Hemorrhage during tonsillectomy is related to the surgical technique, management of bleeding, and choice of anesthetic agent. This study evaluated the effects of anesthetic agents on hemorrhage during tonsillectomy with standardized surgical techniques and management of bleeding. STUDY DESIGN: Double-blind, randomized controlled trial. SUBJECTS AND METHODS: Sixty patients, aged 3 to 12 years, who were scheduled for elective tonsillectomy were enrolled in the study. Propofol-based anesthesia was administered to the first group; desflurane-based anesthesia, to the second. The amount of blood loss due to hemorrhage was measured. RESULTS: Propofol-based anesthesia significantly decreased bleeding during tonsillectomy. CONCLUSION: Propofol-based anesthesia is a reliable method for use in children who undergo tonsillectomy. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.Öğe The effect of dacryocystorhinostomy on mucociliary function(Mosby-Elsevier, 2009) Okuyucu, Semsettin; Akoglu, Ertap; Oksuz, Huseyin; Gorur, Hatice; Dagli, SafakOBJECTIVE: External dacryocystorhinostomy is suspected to cause mucociliary dysfunction by affecting ciliary activity and quality of the mucus. We hypothesized that patients who undergo endoscopic dacryocystorhinostomy may also experience mucociliary dysfunction. We evaluated the effects of surgery on mucociliary clearance time in patients who underwent endoscopic dacryocstorhinostomy and external dacryocstorhinostomy. STUDY DESIGN: A prospective controlled study. SUBJECTS AND METHODS: Forty-four patients were studied: 22 had undergone one-sided endoscopic Surgery and 22 had undergone one-sided external surgery for nasolacrimal duct obstruction. Nonoperated sides of the both groups were remained as controls. The saccharin test was used to evaluate the mucociliary clearance time of the both sides. RESULTS: Dacryocystorhinostomy, results in prolonged mucociliary clearance times either endoscopic or external approach is performed (P < 0.001, paired t test). There was no significant difference between the mucociliary clearance times after endoscopic and external dacryocystorhinostomy), (P = 0.22, Student's t test). CONCLUSION: Dacryocystorhinostomy impairs mucociliary function independent of the type of surgery.Öğe The Effect of Passive and Active Smoking on Nasal Mucociliary Clerarance Time(Derman Medical Publ, 2016) Ozler, Gul Soylu; Simsek, Gokce Ozel; Akbay, Ercan; Akoglu, ErtapAim: The aim of this study was to investigate the effect of passive and active smoking on NMC by comparing the results of age and sex matched healthy individuals, passive and active smokers. Material and Method: A total of 75 subjects met the criteria and were divided into three groups: control group (nonsmokers, group 1, n = 25), passive smokers group(group 2, n = 25), active smokers group (group 3, n = 25). NMC of these subjects were measured and compared. Moreover, the amount of cigarette consumption of active smokers group were calculated as package to year and the correlation between NMC and the amount of cigarette consumption. in active smokers group were evaluated. Results: The mean NMC in passive smokers group and active smokers group were significantly longer than the control group (p= 0,0001) The comparison of NMC values between the passive smokers group and the active smokers group revealed no statistically significant differences (p >= 0,05). There was positive correlation between the increase in NMC and amount of cigarette consumption in the active smokers group (p= 0,0001, r= 0.433). Discussion: Both active and passive smoking prolonged nasal mucociliary clearance time when they were compared with healthy controls. Tobacco exposure is associated diseases such as asthma, chronic rhinosinusitis, and lower airway infections. It may be related to the direct effect of prolonged NMC.Öğe Effect of the N-acetylcysteine and selenium on healing of experimental maxillary sinusitis caused by Staphylococcus aureus(Academic Journals, 2012) Akoglu, Ertap; Hakverdi, Sibel; Kontas, Tunay; Duran, Nizami; Altug, Muhammed Enes; Onel, Suleyman Ercument; Okuyucu, SemsettinThe purpose of this controlled-randomised study was aimed to test the antioxidative effect of the N-acetylcysteine (NAC) and selenium on healing of Staphylococcus aureus sinusitis. After experimental sinusitis, 30 New Zealand rabbits were randomly divided into three groups; group A was treated with Ampicillin/sulbactam and physiological saline. Group B and C were treated with NAC and selenium in addition to Ampicillin/sulbactam, respectively. The measurements were repeated at the 3rd and 10th day. Serum malondialdehyde (MDA) levels and superoxide dismutases (SOD) activities at the 3rd day of experiment were higher than basal levels in all groups. These levels at the 10th day were lower than those of the 3rd day in groups B and C, significantly. The severity of the grade of inflammation and epithelial changes were significant between the infected and control side, but no significant change was found among the groups. S. aureus sinusitis causes to increase the level of reactive oxygen species (ROS) in the blood. These increased levels of ROS can be neutralized in some degree by antioxidative effects of NAC and selenium which are supplemented to standard antibiotic therapy. The effect of NAC and selenium on healing of maxillary sinus mucosa seems to be insignificant.Öğe Effects of cognitive tasks on eye movements(Springer Heidelberg, 2022) Sarac, Elif Tugba; Batuk, Merve Ozbal; Yarali, Mehmet; Karadag, Mehmet; Aksoy, Songul; Akoglu, ErtapEye movements are guided by vestibular and visual information. The vestibulo-ocular knowledge of the vestibule includes eye movements in the opposite direction of head movements. This study investigated the effect of auditory what and where tasks on the visual where to evaluate the effects of cognitive tasks on eye movements. All subjects underwent testing with videonystagmography (VNG). The VNG battery of saccade and tracking oculomotor tests were performed. The study design was planned in three stages: (1) without any cognitive tasks, eye movements were recorded with VNG, (2) participants were asked to tell what sound they heard during VNG recording, and (3) the subject was asked to tell from what direction, or where, the sound had come from during VNG recording. Providing individuals with a cognitive task changed the test results negatively in all parameters. Giving cognitive tasks to individuals spoils all VNG parameters. The VNG oculomotor tests are affected by the dual tasks. Daily tasks such as sound object localization and recognition have a significant effect on scanning the visual environment in daily life such as during driving or walking in a crowded environment.Öğe Effects of valproic acid on hearing in epileptic patients(Elsevier Ireland Ltd, 2007) Incecik, Faruk; Akoglu, Ertap; Sanguen, Zlem; Melek, Ismet; Duman, TaskinObjective: Since some case reports about the ototoxicity of valproic acid have been published, probable adverse effects of valproic acid on hearing in the epileptic patients became a subject of interest. We wanted to investigate if ototoxicity occurs in pediatric epileptic patients using VPA for long terms. Methods: Twenty-one epileptic patients who have been using valproic acid at least for 6 months as monotherapy and 21 age-sex matched controls were included in the study. Audiometric tests were performed to all patients between the frequencies of 125 and 16,000 Hz. The effects of dosage, duration of therapy and serum levels of the VPA, on the audiometric results were investigated and the audiometric results were compared between the groups. Results: There was no difference in hearing thresholds of the groups between 125 and 16,000 Hz frequencies. Relation could not be established between the duration of VPA therapy, dosage of the drug, blood level of drug, age and sex of the patients and the auditory signs. Conclusions: Although we could not find any deleterious effect of VPA on hearing thresholds in our patient series, we think it is useful to perform audiometric tests at intervals while VPA is being used for tong periods, considering the presented case reports about sensorineural hearing loss. (c) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe Endoscopic dacryocystorhinostomy with silicone, polypropylene, and T-tube stents; randomized controlled trial of efficacy and safety(Ocean Side Publications Inc, 2015) Okuyucu, Semsettin; Gorur, Hatice; Oksuz, Huseyin; Akoglu, ErtapObjective: To compare the efficacy and safety of endoscopic dacryocystorhinostomy (En-DCR) with different stent materials for lacrimal sac intubation inprimary nasolacrimal ductal obstructions. Study Design: Randomized controlled study with three parallel groups. Level of evidence is 1b. Methods: A total of 91 patients (five bilateral) with primary nasolacrimal duct obstruction (NLDO) at a tertiary referral center scheduled for En-DCR were to allocated into three stent groups with a sealed envelope and were randomized into three treatments: silicone, Prolene (polypropylene), and otologic T-tube. Ophthalmology and otolaryngology clinics evaluated the patients preoperatively and postoperatively with endoscopes, lacrimal system syringing, and dacryocystography. The success of the stents was evaluated 12 months after surgery with symptom relief and ostial patency. Complications were also noted. Results: The overall success rate of the En-DCR in the stent groups was 78.1% (75/96); specifically, 87.5% (28/32) with silicone, 84.4% (27/32) with Prolene, and 62.5% (20/32) with T-tube. The efficacy of the procedures with the T-tube was significantly lower than that of the Prolene and silicone (p =.031, x(2) test). There were no significant differences between the silicone and Prolene (p =.718, x(2) test). Prolene was found to be related with orbital complications. Spontaneous loss is a particular complication of otologic T-tube and highly portends to failure. Conclusions: The results of our study suggest that efficacy, defined as anatomic and functional success, is equally high for silicone and Prolene stents and lower for otologic T-tube in En-DCR.Öğe Evaluation of the turbinate hypertrophy by computed tomography in patients with deviated nasal septum(Mosby-Elsevier, 2007) Akoglu, Ertap; Karazincir, Sinem; Balcı, Ali; Okuyucu, Semsettin; Sumbas, Haldun; Dagli, Ali SafakOBJECTIVES/HYPOTHESIS: To determine the dimensions of the compensatory hypertrophic inferior turbinate and investigate the radiological changes in the morphology of the conchal bone in patients with septal deviation. STUDY DESIGN: A retrospective chart review. METHODS: The mucosal and bone compartments of the hypertrophic turbinate were measured using computed tomography (CT) in patients with septal deviation, and the conchal bones were classified radiologically as lamellar, compact, and combined types. The results were compared with those of controls. RESULTS: The dimensions of the bony and mucosal components of the inferior turbinate were significantly greater than those of controls in the anterior and middle segments, while the morphological changes in the conchal bone were not different. CONCLUSION: The significant bony and mucosal enlargement in the anterior and middle segments of the inferior turbinate supports turbinate reduction at the time of septoplasty and the CT findings should be considered when making a decision about the reduction type. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.Öğe Ex Vivo Tracheal Mucociliary Clearance in Rats: Comparisons of Nebulization versus Irrigation with Lactated Ringer and Saline Solutions(Bmc, 2009) Okuyucu, Semsettin; Akoglu, Ertap; Babayigit, Cenk; Akoglu, Sebahat; Dagli, SafakObjective: This study was performed to compare the effects of isotonic saline, hypertonic saline (buffered/nonbuffered), and lactated Ringer irrigation and distilled water nebulization on mucociliary clearance in ex vivo rats. Design: Experimental study. Setting: Tertiary otolaryngology care centre. Methods: Thirty rat tracheas were achieved from 15 rats by dividing the trachea longitudinally into two equal parts. Main Outcome Measures: Mucociliary transport velocity was measured by direct observation of particle placed on the lower end of the trachea after irrigation or nebulization. Results: Significant improvement in mucociliary clearance was found with isotonic saline (p = .002), buffered hypertonic saline (p = .018), lactated Ringer (p = .000), and nebulized distilled water (p = .000) when compared with nonbuffered hypertonic saline. Conclusion: Lactated Ringer solution is better than saline solution at enhancing mucociliary clearance, but nebulized distilled water is superior to the tested irrigation solutions in rat tracheal epithelium.Öğe Impairment of nasal mucociliary clearance time in wood industry workers(Springer, 2020) Ozler, Gul Soylu; Akoglu, ErtapPurpose The aim of this study is to investigate the effect of wood dust on nasal mucociliary clearance time in wood industry workers. Moreover, the correlation between duration of exposure to wood dust and nasal mucociliary clearance time will be evaluated. Methods A total of 50 male subjects were included in the study. All of the subjects were non-smokers. Nasal mucociliary clearance time of 25 wood industry workers was measured with saccharine method and compared with the results of 25 age-matched control group. Also, the correlation between nasal mucociliary clearance time and duration of exposure to wood dust in woodworkers was evaluated. Results The mean mucociliary clearance time in control group and wood industry workers was 12.28 +/- 1.98 and 16.72 +/- 2.71, respectively. The mean mucociliary clearance time in wood industry workers was significantly longer than control group (p < 0.0001). Also,there was positive correlation between duration of exposure to wood dust and nasal mucociliary clearance time in wood industry workers (r = 0.879, p < 0.0001). Conclusion The clinicians must remember that mucociliary clearance time in wood industry workers is prolonged. So the wood industry workers must be followed up more closely for sinonasal infections and respiratory tract diseases.Öğe Intravenous ketamine and local bupivacaine infiltration are effective as part of a multimodal regime for reducing post-tonsillectomy pain(Int Scientific Information, Inc, 2009) Inanoglu, Kerem; Akkurt, B. Cagla Ozbakis; Turhanoglu, Selim; Okuyucu, Semsettin; Akoglu, ErtapBackground: The aim of this study was to investigate the effects of a multimodal analgesic regimen, including intravenous ketamine and peritonsillar infiltration of bupivacaine, on post-tonsillectomy pain in children. Material/Methods: Ninety children aged 2-12 years, undergoing tonsillectomy, were enrolled in this randomized, controlled and double-blinded study. Group I (n=30) received intravenous and peritonsillar saline, group II (n=30) received intravenous saline and peritonsillar bupivacaine, and group III (n=30) received intravenous 0.5 mg/kg ketamine and peritonsillar 0.25% bupivacaine (3-5 ml per tonsil). Pain was evaluated using a modified Children's Hospital of Eastern Ontario Pain Scale (mCHEOPS) recorded 15 min and 1, 4, 12, 16, and 24 h postoperatively. Results: No difference was found in the demographic data among the groups. Group I patients who received intravenous and peritonsillar saline solution as placebo had higher pain scores at 15(th) min, and Ist and 4(th) h than group II, and at all time intervals, than group III (P<0.05). Patients in group III also had significantly lower pain scores than group II at all time intervals except at 15(th) min (P<0.05). Analgesic requirements and the time to first analgesia were also significantly (P<0.05) better in the ketamine group. Conclusions: Intravenous ketamine and peritonsillar infiltration with bupivacaine are safe and effective as part of a multimodal regime in reducing post-tonsillectomy pain.Öğe ISOLATED CYST HYDATID: AN UNUSUAL CAUSE OF A MASS IN THE NAPE OF THE NECK(Nobel Ilac, 2009) Okuyucu, Semsettin; Balcı, Ali; Karazincir, Sinem; Akoglu, Ertap; Gozel, Serhat; Dagli, SafakBecause of the rarity of hydatid cyst in the head and neck area, it may be overlooked by the clinicians. We report a case of primary hydatid cyst in the posterior cervical region without another organ involvement. A 54-year-old woman presented with a large, painless lump in the nape of the neck. A computed tomography scan demonstrated a 5x5x4 cm hypodense mass which is located in the left scalen muscles. An axial magnetic resonance image revealed well-defined high signal intensity mass with low signal intensity rim, which is considered as a characteristic feature for hydatid cyst. She underwent surgery to excise the cyst. Histopathological examination confirmed the diagnosis as a hydatid cyst. If a cystic mass in head and neck area exists, hydatid disease must be kept in mind, especially in endemic areas, to avoid the complications such as acute anaphylaxis or recurrences due to inappropriate management.Öğe Mean Platelet Volume Evaluation in Patients with Nasal Polyp: Methodological Drawbacks Reply(Galenos Yayincilik, 2015) Cevik, Cengiz; Yengil, Erhan; Akbay, Ercan; Arli, Cengiz; Gulmez, Mehmet Ihsan; Akoglu, Ertap[Abstract Not Available]
