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Öğe Bilateral Abducens Paralysis Secondary to Compression of Abducens Nerve Roots by Vertebrobasilar Dolichoectasia(Informa Healthcare, 2013) Tuzcu, Esra Ayhan; Bayarogullari, Hanifi; Coskun, Mesut; Yilmaz, Cahide; Ilhan, Nilufer; Daglioglu, Mutlu Cihan; Aras, MustafaVertebrobasilar dolichoectasia is characterized by dilatation, tortuosity, and marked elongation of the vertebral and basilar arteries. Dolichoectatic arteries usually have thin arterial walls secondary to degeneration of the internal elastic lamina, reticular fibre deficiency, and smooth muscle atrophy. This anomaly is relatively uncommon and generally asymptomatic. Clinical manifestations of dolichoectasia result from the compression and displacement of adjacent structures, causing cranial nerve palsy, obstructive hydrocephalus, or ischaemic stroke. The authors present a case in which vertebrobasilar dolichoectasia led to the development of bilateral abducens nerve paralysis in a 9-year-old girl.Öğe Birleşik lumbosacral sinir kökleri(2012) Altaş, Murat; Aras, Mustafa; Urfalı, Boran; Türkyılmaz, AtilaKonjenital anatomik anomaliler arasında lumbosakral sinir kökü anomalileri nadir görülen bir gruptur. Literatür incelendiğinde çok farklı lumbosakral sinir kökü anomalilerinin raporlandığı gözlenebilmektedir. Bu anomalilerin alt grupları kabaca bifid, birleşik yapı, transvers yönde veya anostomozlaşmış yapıda olmaları şeklinde sınıflandırılmaktadır. Görüntüleme yöntemlerinin gelişmesinden önce bu yapılar otopsi çalışmaları ve lumbar disk herniasyonuna yönelik cerrahi girişimler sırasında insidental olarak gözlenmiştir ve çoğunlukla asemptomatikirler.Öğe Calcified chronic subdural hematoma(2012) Aras, Mustafa; Altaş, Murat; Yilmaz, Atilla; Serarslan, Yurdal; Urfali, Boran; Yilmaz, NebiCalcified subdural hematoma is a rarely seen event. It may develop secondary to previous trauma or inappropriate surgical procedures. Due to the not well understood etiology, there are variations in the treatment choices. We present a 27-year old male patient with calcified chronic subdural hematoma. He was operated on following an motorcycle accident in another hospital 5 years ago. He was admitted to our hospital complaining about seizure, headache and dizziness. Neuroradiological examination revealed a calcified chronic subdural hematoma was detected on the right hemisphere. The patient was hospitalized and put on anti-epileptic and analgesic drugs. Any surgical treatment was not applied. In cases with calcified chronic subdural hematoma, the decision of surgical operation should be decided after a carefully and meticulously investigation. It should be avoided any profitless and likely harmful surgical procedures. The clinical observation may be appropriate in the determination of treatment approaches. © 2012 OMU.Öğe Delayed Seizure With Intracranial Sewing Needles(Lippincott Williams & Wilkins, 2013) Aras, Mustafa; Altas, Murat; Serarslan, Yurdal; Davran, Ramazan; Bayarogullari, Hanifi; Cagli, SedatPenetrating head injuries are the main cause of intracranial foreign bodies. They can lead to complaints such as headaches and seizures at a later period. We report the case of a patient with sewing needles inserted within the parietal lobe. The primary complaint of the patient was epileptic seizures. The patient was treated with antiepileptic drugs. Surgical intervention was not considered. The removal of intracranial needles is still controversial in the literature. In our case, needles were not removed because the epileptic seizures were successfully treated with antiepileptic medication.Öğe The Dowling-Orlando technique in a giant primary cerebral hydatid cyst: a case report(Via Medica, 2010) Altas, Murat; Serarslan, Yurdal; Davran, Ramazan; Evirgen, Omer; Aras, Mustafa; Yilmaz, NebiHydatid cyst disease is a parasitic illness that is rarely located in the brain. We present a case of a 26-year-old female who complained of headache, nausea, and vomiting. The diagnosis was intracranial hydatid cyst disease and was confirmed with radiological and serological tests. Neurological examination revealed papilloedema and left-sided pyramidal signs. She was operated on using the Dowling-Orlando technique. The cyst was removed without rupture, and therapy was completed with albendazole for a period of four weeks. In this article, we discuss the application of the Dowling-Orlando technique, microsurgery, the Valsalva manoeuvre and the positioning of the patient such that gravity could facilitate surgical removal of a giant cerebral hydatid cyst.Öğe The effect of subthalamic nucleus - Deep brain stimulation and different stimulation frequencies on cerebral hemodynamics in Parkinson's disease: A transcranial doppler study(Elsevier, 2020) Koban, Orkun; Yildizgoren, Mustafa Turgut; Aras, Mustafa; Oral, Sukru; Uyanik, Sadik Ahmet; Serarslan, Yurdal; Okuyucu, Esra EmineObjectives: To investigate the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) and to compare low-frequency versus high-frequency STN-DBS on hemodynamic parameters of the middle cerebral artery between patients with advanced Parkinson's disease and age-sex matched healthy controls. Patients and Methods: Eighteen patients with advanced Parkinson's disease (PD) with bilateral STN-DBS and 18 control subjects underwent Transcranial Doppler Ultrasound (TCDU) were included in the study. The hemodynamic parameters including blood flow velocity (FV), pulsatility index (PI) and, resistance index (RI) of the right middle cerebral artery (MCA) were measured and compared during the phases using TCDU. The first DBS-off, the second low-frequency DBS of 60 Hz, and the third high-frequency DBS of 130 Hz were compared. Results: PD patients had significantly higher MCA-PI values compared with controls (0.99 +/- 0.27 vs. 0.82 +/- 0.14) (p = 0.031). Also, the MCA-PI values were higher in the low-frequency DBS (0.94 +/- 0.14) and high-frequency DBS (0.93 +/- 0.16) than in the controls (0.82 +/- 0.14) (p = 0.022 and p = 0.041, respectively). There were no significant differences of FV and RI values among the DBS-on, DBS-off and, controls. The RI values were higher in the PD patients than in the controls, although these were not statistically significant. Also, PI values of the MCA decrease in different frequencies (60 Hz or 130 Hz). Conclusion: The results of this study showed that MCA-PI values are higher in advanced PD compared with controls. These indices indicate that MCA resistances and impedances are increased in advanced PD. Low- or high-frequency DBS treatment have beneficial effect to reduce high PI in advanced PD patients.Öğe Giant calvarial meningioma which obliterated superior sagittal sinus: Case report(2012) Altaş, Murat; Aras, Mustafa; Bayaro?ullari, Hanifi; Karcio?lu, Murat; Serarslan, Yurdal; Yilmaz, NebiInterosseous meningioma, defined as meningiomas confined to the skull with no epidural or subcutaneous component, is a rarely encountered example of the primary meningiomas. It is usually a benign tumour and takes origin from arachnoids cap cells. Several etiological hypotheses have been asserted for interosseous meningiomas up to the present. The literature pointed out that the symptoms of the patients with meningiomas might vary. The findings of osteolysis and hyperostosis might also be seen by X-Ray radiograph imaging. Our case was a male and 21 years old. He admitted the polyclinics of neurosurgery with the complaint of convulsion. Intracranial component of the meningioma was measured as 90 × 42 mm in MRI. Imaging indicated that this was a giant calvarium meningioma which diffusely skirted along to suture lines and obliterated superior sagittal sinus in a wide area. Clinical and radiological properties of the tumour were evaluated, and the responsible mechanisms from its pathogenesis are discussed in the light of the literature. © 2012 OMU.Öğe Günübirlik lomber mikrodiskektomi operasyonlarını izleyen postoperatif bulantı kusmanın tedavisinde ondansetrona deksametazon ilavesi(2015) Davarcı, Işıl; Tuzcu, Kasım; Hakimoğlu, Sedat; Karcıoğlu, Murat; Aras, Mustafa; Altaş, Murat; Turhanoğlu, SelimAmaç: Çalış mam ızda, deksametazonun ondansetronla kombinasyonunun lomber mikrodiskektomilerde postoperatif bulant ı kusmay ı (POBK) önlemedeki etkinliklerini karş ıla ş t ırmay ı amaçladık. Gereç ve Yöntem: Günübirlik mikrodiskektomi operasyonu uygulanacak American Society of Anesthesiologists (ASA) I-II, 60 hasta rastgele 3 gruba ayr ıldı: grup D; 8mg deksametazon, grup O; 4mg ondansetron, grup P; 8mg deksametazon ve 4mg ondansetron. Postoperatif bulantı ve kusma ve a ğ r ı s ıklığ ı ile antiemetik ve analjezik ihtiyaçlar ı cerrahi sonras ında 3-12 ve 24. saatlerde de ğ erlendirildi. Bulgular: Postoperatif ilk 3 saatte bulantı insidans ı grup D ve grup O’ya kıyasla grup P’de anlamlı olarak azalm ış t ı (p<0.046 ve p<0.021, s ıras ıyla). Bu dönemde ilave antiemetik kullanım ı, grup P’de grup D ve grup O’ya kıyasla anlamlı olarak azalm ış tı (p<0.030 ve p<0.023, s ıras ıyla). Çalış mam ızda; kadın cinsiyet, sigara içmeme, POBK veya ta ş ıt tutma hikâyesi POBK’nın tahmininde anlamlı risk faktörleriydi. Oral su/g ıda alma zamanı ve taburcu olma süreleri diğ er gruplara kıyasla grup P’de anlamlı olarak azalm ış ken (p<0.012, p<0.003 ve p<0.005, p<0.007, s ıras ıyla), POBK görülen hastalarda ise anlamlı olarak artm ış tı (p<0.007 ve p<0.029, s ıras ıyla). Sonuç: Günübirlik lomber mikrodiskektomilerde deksametazonun ondansetronla kombinasyonu antiemetik etkinliğ i arttırarak hastaların daha erken oral su/g ıda almalar ını ve daha erken taburcu olmalarını sa ğ lam ış tır.Öğe Infected colloid cyst(Springer, 2017) Yilmaz, Atilla; Aras, Mustafa; Serarslan, Yurdal; Kaya, Mustafa EmrahIntroduction Colloid cysts are the most common pathologic lesions of the third ventricle. Although they are histologically benign, they may grow and can cause the hydrocephalus. Case summary A 5-year-old male patient underwent to surgery with the diagnosis of colloid cyst. In operation, after the anterior transcallosal approach, the cyst was punctured by syringe and obviously pus aspirated. Conclusion Colloid cysts mostly remain silent and detected incidentally. Although it is rarely defined, rhinorrhea, hypopituitarism, diabetes insipidus, spasmodic torticollis, drop attack, aseptic meningitis, and coexistence with neurocysticercosis have been reported, but this is the first reported case of an infected colloid cyst.Öğe Intracranial meningiomas: Two-years experience of Mustafa Kemal University(Ondokuz Mayis Universitesi, 2013) Özgür, Tümay; Altas, Murat; Aras, Mustafa; Atik, Esin; Yaldiz, Mehmet; Yilmaz, NebiMeningiomas are the most common type of brain tumors. We have analyzed clinical, radiological and pathological characteristics of meningiomas that were diagnosed and operated in our centre. Twenty three meningioma cases operated in our hospital between 2010-2012 were reviewed retrospectively. Sixteen (69.1%) of cases were female and 7 (30.9%) of cases were male. The age range was 22-75. The most common symptoms of patients were headache, seizure, nausea and vomitting. Localizations of tumors were falx, cortex, sphenoid wing, posterior fossa-tentorium, olphactor, and sulcus. The surgical sizes were graded according to Simpson classification and 16 (69.1%) of cases were Grade 2 and 7 (30.9%) of cases were Grade I. At the histopathological examination; meningotheliomatous type was the most common type followed by fibrous, angiomatous, transitional, psammomatous and atypical types. Meningiomas are usually benign tumors with good prognosis which are often encountered in daily pathology and neurosurgery practice. © 2013 OMU.Öğe Kafaiçi anevrizmalarda bilgisayarlı tomografik anjiografinin yeri(2013) Altaş, Murat; Aras, Mustafa; Bayaroğulları, Hanifi; Yılmaz, Atilla; Serarslan, Yurdal; Yılmaz, Nebi; Atcı, NesrinAmaç: Serebral anevrizmaların tanısında geçerli olan üç yöntem vardır. Bunlar; manyetik rezonans anjiografi (MRA), dijital substraksiyon anjiografi (DSA) ve 3 boyutlu komputerize tomografi anjiografi (CTA) dir. Biz bu çalışmada CTA’nin avantajlarının ve sınırlarının anlaşılması, DSA ile karşılaştırılarak tedavi metodu konusunda farlılık olup olmamasını inceledik. Yöntem ve Gereç: Mustafa Kemal Üniversitesi, Beyin ve Sinir Cerrahisi Anabilim dalında son 2 yılda, kontrastsız CT tetkikinde, subaraknoid kanama tespit edilen ve bu nedenle takip ve tedavi altına alınan 40 hasta çalışmaya dahil edildi. Bulgular: Çalışmaya dahil edilen 40 olguya, üç gün içinde önce CTA, daha sonra DSA yapıldı. Olguların 10’unda (%25) anevrizma tespit edilemedi. 30 olguda (%75) anevrizma tespit edildi. Anevrizmaların en küçüğü 3x2 mm, en büyüğü 7x11 mm boyutlarında idi. Tartışma: DSA, anevrizmaların tanısında ve değerlendirilmesinde altın standart görüntüleme yöntemi olarak kabul edilmektedir. Ancak DSA zaman alan, pahalı, düşükte olsa komplikasyonlara neden olabilen bir yöntemdir. Sonuç: Bizim çalışmamızın bulguları ışığında, CTA’nin DSA’ya göre bazı dezavantajları olmasına rağmen, anevrizma tanısında DSA kadar efektif bir tanı yöntemidir.Öğe Non-traumatic spontaneous acute epidural hematoma in a patient with sickle cell disease(Elsevier Doyma Sl, 2014) Serarslan, Yurdal; Aras, Mustafa; Altas, Murat; Kaya, Hasan; Urfali, BoranA 19-year-old female with sickle cell anemia (SCD) was referred to our hospital after two days of hospitalization at another hospital for a headache crisis. This headache crisis was due to a raised intracranial pressure; these symptoms were noted and included in her comprehensive list of symptoms. There was an acute drop in the hemoglobin and hematocrit levels. The cranial CT scan demonstrated a left fronto-parietal acute epidural hematoma (AEH) and a calvarial bone expansion, which was suggestive of medullary hematopoiesis. The patient underwent emergent craniotomy and evacuation of the hematoma. There were no abnormal findings intra-operatively apart from the AEH, except skull thickening and active petechial bleeding from the dural arteries. Repeated CT scan showed a complete evacuation of the hematoma. The possible underlying pathophysiological mechanisms were discussed. In addition to the factors mentioned in the relevant literature, any active petechial bleeding from the dural arteries on the separated surface of the dura from the skull could have contributed to the expanding of the AEH in our patient. Neurosurgeons and other health care providers should be aware of spontaneous AEH in patients with SCD. (C) 2013 Sociedad Espanola de Neurocirugia. Published by Elsevier Espana, S.L. All rights reserved.Öğe Oxidative Status in Epileptic Children Using Carbamazepine(Briefland, 2015) Tutanc, Murat; Aras, Mustafa; Dokuyucu, Recep; Altas, Murat; Zeren, Cem; Arica, Vefik; Ozturk, Oktay HasanBackground: There is an increasing attention towards the relationship between oxidative stress and epilepsy. The effect of antiepileptic drugs on oxidant status is of major interest. Antiepileptic drugs can increase levels of free radicals, which consequently might lead to seizures. Carbamazepine (CBZ) is an antiepileptic drug commonly used in childhood and adolescence. Objectives: Therefore we aimed to investigate the effects of CBZ on total antioxidant status, total oxidant stress, and oxidative stress index. Patients and Methods: The study included 40 epileptic patients and 31 healthy children between 4 and 12 years of age. Serum CBZ level, total antioxidant capacity and total oxidant status were measured. Oxidative stress index was also calculated both in controls and patients. Results: In the epileptic group, decreased levels of total antioxidant capacity, increased total oxidative stress and oxidative stress index levels were found. Positive correlation between plasma CBZ levels and total oxidant status was observed. Conclusions: Antioxidant action could not be playing any role in antiepileptic effect of CBZ. Furthermore, increased oxidative stress induced by CBZ could be the cause of CBZ-induced seizures. Therefore combining CBZ with antioxidants could be beneficial.Öğe Percutaneous Kyphoplasty Is Bilateral Approach Necessary?(Lippincott Williams & Wilkins, 2018) Yilmaz, Atilla; Cakir, Murteza; Yucetas, Cem Seyho; Urfali, Boran; Ucler, Necati; Altas, Murat; Aras, MustafaStudy Design. A multicenter retrospective study of patients who underwent unilateral and bilateral balloon kyphoplasty. Objective. The aim of this study was to compare the radiographic and clinical results of unilateral and bilateral balloon kyphoplasty to treat osteoporotic vertebral compression fractures. Summary of Background Data. Percutaneous kyphoplasty has long been used as a successful method in the treatment of osteoporotic vertebral compression fractures. Although the bilateral approach is considered to be the mainstay application of percutaneous kyphoplasty, the unilateral approach has also been shown to be sufficient and even more effective in some cases. Methods. A total of 87 patients who underwent percutaneous kyphoplasty due to osteoporotic vertebral compression fractures between 2009 and 2016 were retrospectively evaluated and divided into two groups as patients who underwent unilateral or bilateral percutaneous kyphoplasty. Unilateral percutaneous kyphoplasty was performed in 36 and bilateral percutaneous kyphoplasty in 51 patients. The groups were compared in terms of clinical outcomes, radiological findings, and complications. Clinical outcomes were evaluated using Visual Analogue Scale and Oswestry Disability Index and the radiological findings were evaluated by comparing the preoperative and postoperative day 1 and year 1 values of anterior, middle, and posterior vertebral heights and kyphosis angle. Results. Clinical improvement occurred in both groups but no significant difference was observed. In radiological workup, no significant difference was found between the groups in terms of improvements in vertebral heights and kyphosis angle. Operative time and the amount of cement used for the surgery were significantly lower in the patients that underwent unilateral kyphoplasty. Conclusion. Unilateral percutaneous kyphoplasty is as effective as bilateral percutaneous kyphoplasty both radiologically and clinically. Operative time and the amount of cement used for the surgery are significantly lower in unilateral kyphoplasty, which may play a role in decreasing complication rates.Öğe Profilaktik anti epileptik kullanımı sonrası gelişen toksik epidermal nekrolizis(2012) Altaş, Murat; Aras, Mustafa; Yılmaz, Atila; Sarıkaya, Gökhan; Urfalı, Boran; Serarslan, Yurdal; Yılmaz, NebiToksik epidermal nekroliz (TEN) ya da Lyell sendromu, derinin tüm tabakalarını içine alan yaygın epidermal eksfoliasyon, ateş, konjonktivit, rinit, öksürük, boğaz ağrısı, miyalji ve mukozal membran tutulumu ile karakterize idiosinkrazik sistemik bir hastalıktır. TEN gelişiminin en sık nedeni ilaçlardır. Tanı konulduktan sonra, tedavide sebep olan ilaç kesilmeli ve destek tedavisi verilmelidir. Antiepileptikler nöroşirurji pratiğinde profilaktik olarak sık kullanılan ve kullanımında halen ortak bir görüşün sağlanamadığı ilaçlardır. Burada profilaktik olarak kullanılan fenitoinden kısa bir süre sonra TEN gelişen 51 yaşında bayan hasta sunularak nöroşirurji pratiğinde profilaktik antiepileptik kullanımı vurgulanmıştır.Öğe Protective Effects of Edaravone on Experimental Spinal Cord Injury in Rats(Karger, 2011) Ozgiray, Erkin; Serarslan, Yurdal; Ozturk, Oktay Hasan; Altas, Murat; Aras, Mustafa; Sogut, Sadik; Yurtseven, TaskinBackground: Spinal cord injury (SCI) is a leading cause of morbidity and mortality among youth and adults. Secondary injury mechanisms within the spinal cord (SC) are well known to cause deterioration after an acute impact. Free radical scavengers are among the most studied agents in animal models of SCI. Edaravone is a scavenger of hydroxyl radicals. Methods: We aimed to measure and compare the effects of both methylprednisolone and edaravone on tissue and on serum concentrations of nitric oxide (NO), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, and tissue total antioxidant capacity (TAC) in rats with SCI. SCI was induced in four groups of Wistar albino rats by a weight-drop method. The neurological function of the rats was periodically tested. At the end of the experiment, blood samples were collected, and SC tissue samples were harvested for biochemical evaluation. Results: The tissue level of NO was decreased in the edaravone-treated group compared with the no-treatment group (p < 0.05). The tissue levels of SOD and GSH-Px were higher in the edaravone-treated group than in the no-treatment group (p < 0.05). The serum levels of NO were lower in the edaravone-treated and methylprednisolone-treated groups than in the no-treatment group (p < 0.05). The serum levels of SOD in the edaravone-treated group did not differ from those of any other group. The serum levels of MDA in the edaravone-treated and no-treatment groups were higher than in the two other groups (p < 0.05). Tissue levels of MDA in the edaravone-treated group were lower than in the no-treatment group (p < 0.05). Tissue levels of TAC in the edaravone-treated group were higher than in the no-treatment and methylprednisolone-treated groups (p < 0.05). The neurological outcome scores of the animals in treatment groups did not depict any statistically significant improvement in motor functions. However, edaravone seemed to prevent further worsening of the immediate post-SCI neurological status. Conclusion: Our biochemical analyses indicate that edaravone is capable of blunting the increased oxidative stress that follows SCI. We show, for the first time, that edaravone enhances the TAC in SC tissue. This beneficial effect of edaravone on antioxidant status may act to minimize the secondary neurological damage that occurs during the acute phase after SCI. Copyright (C) 2012 S. Karger AG, BaselÖğe Protective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brain(Karger, 2013) Aras, Mustafa; Urfali, Boran; Serarslan, Yurdal; Ozgur, Tumay; Ulutas, Kemal Turker; Urfali, Senem; Altas, MuratThe aim of this study was to assess the effects of minocycline on cerebral ischemia-reperfusion (I/R) injury in rats. The study was carried out on 24 male Wistar albino rats, weighing 200-250 g, which were divided into three groups: (i) control (n = 8), (ii) I/R (n = 8) and (iii) I/R + minocycline (n = 8). Minocycline was administrated at a dose of 90 mg/kg p.o. to the I/R group 48, 24 and 1 h before ischemia. Following bilateral exposure of the common carotid arteries by anterior cervical dissection and separation of the vagus nerve, I/R injury was performed by occlusion. Following reperfusion, malondialdehyde (MDA), superoxide dismutase, glutathione peroxidase and catalase levels in the blood and brain tissue, and creatine kinase (CK), CK-BB, lactate dehydrogenase (LDH), neuron-specific enolase (NSE) and protein S100 beta levels in the blood were measured and the histopathological changes were monitored. Regarding histopathological evaluation, symptoms of degeneration were significantly improved in the I/R + minocycline group compared to the I/R-only group. Statistical analysis of the biochemical parameters revealed significant differences in MDA (p < 0.001), nitric oxide (p < 0.05), CK (p < 0.05) and CK-MB (p < 0.05) levels between the I/R + minocycline group and the I/R group. According to the literature, the effect of minocycline is firstly assessed by LDH, CK-MB, NSE and S-100 beta analysis in addition to antioxidant status and histopathological analysis. (C) 2014 S. Karger AG, BaselÖğe Protective effects of minocycline on experimental spinal cord injury in rats(Elsevier Sci Ltd, 2015) Aras, Mustafa; Altas, Murat; Motor, Sedat; Dokuyucu, Recep; Yilmaz, Atilla; Ozgiray, Erkin; Seraslan, YurdalBackground: The effects of minocycline on neuronal injury after spinal cord injury (SCI) are limited and controversial. Therefore we aimed to investigate the protective effects of minocycline on tissue and on serum concentrations of malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, tissue total antioxidant and oxidant status (TAS and TOS, respectively), and AST and LDH levels in rats with SCI. Methods: This study was performed on 7-8 weeks 38 male Wistar albino rats. The animals were randomly divided into five groups: group 1, Sham (n = 8); group 2, SCI (spinal cord injury)/control (n = 8); group 3, SCI + minocycline3 (n = 7); group 4, SCI + minocycline30 (n = 8) and group 5 SCI + minocycline90 (n = 7). Blood and tissue samples were analysed for MDA, SOD, GSH-Px, TAS, TOS, AST and LDH levels. Results: The MDA levels were significantly higher in SCI group compared to sham group (p < 0.001), and MDA levels were also significantly higher in SCI group compared to SCI + M-3, SCI + M-30, SCI + M-90 (p < 0.05). SOD levels were significantly higher in SCI + M-30 when compared to SCI and SCI + M-3 groups (p < 0.05). GSH-Px levels decreased significantly in SCI and SCI + M-3 groups compared to sham (p < 0.05). SCI + M-3 group showed significantly decreased levels of TAS and TOS compared to SCI group (p < 0.05). TAS and TOS levels significantly increased in SCI + M-90 group compared to SCI + M-3 and SCI + M-30 groups (p < 0.05). Conclusions: The present study demonstrates the dose-dependent antioxidant activity of minocycline against spinal cord injury in rats. Minocycline administration increased antioxidant enzyme levels and improved total antioxidant status. (C) 2015 Elsevier Ltd. All rights reserved.Öğe Protrusion of a peritoneal catheter via abdominal wall and operated myelomeningocele area: a rare complication of ventriculoperitoneal shunt(Springer, 2013) Aras, Mustafa; Altas, Murat; Serarslan, Yurdal; Akcora, Buelent; Yilmaz, AtillaVentriculoperitoneal shunting is mostly used in the treatment of hydrocephalus, and many complications have been reported with this method. These complications include obstruction, mechanical shunt failure, infection, and abdominal complications. Abdominal complications include intestinal obstruction, volvulus, peritonitis, peritoneal cyst, cerebrospinal fluid ascites, as well as migration of the distal catheter via the intestinal tract, umbilicus, scrotum, and vagina. Various mechanisms have been suggested with regards to the catheter migration. We present a case of a 21-month-old female patient who had myelomeningocele at birth. She underwent repair of the myelomeningocele at the age of 10 days. After 4 months, cranial computed tomography revealed hydrocephalus, and ventriculoperitoneal shunt was placed. Because of shunt dysfunction, a new ventriculoperitoneal shunt system was installed at the age of 12 months. Eight months later, her mother noticed the protrusion of peritoneal catheter via abdominal wall and repaired myelomeningocele area. Revision of the lower end of the shunt was done, and myelomeningocele area was repaired again. We report a unique patient with the protrusion of the distal catheter through repaired myelomeningocele area and abdominal wall in the lumbar region.Öğe The role of MR Myelogram in the diagnosis of traumatic pseudomeningocele(2013) Bayaro?ullari, Hanifi; Atci, Nesrin; Altaş, Murat; Aras, Mustafa; Özden, RaifTraumatic pseudomeningocele is a valuable indicator of nerve root injury. Secondary to trauma, the traction forces firstly tear meninges and later if the traction forces are great enough, nerve root avulsions occur. In this article, we aimed to show pseudomeningoceles localized at the level of brachial and lumbar plexus secondary to nerve root injury. We retrospectively reviewed the patients who admitted to our hospital between 2009 and 2011 due to various accidents. After clinical and radiological examinations, spinal root injuries were detected in six patients at different levels. Brachial plexopathy was detected in four patients and lumbosacral plexopathy was detected in two patients. Pseudomeningocele is a valuable indicator of nerve root injury. It occurs after dural torn like pouch. MR and MR myelography is the best imaging modality to indicate its' pouch and cerebrospinal fluid (CSF) within it. MR and MR myelography are best effective imaging modalities to indicate the pseudomeningoceles due to nerve root injury.
