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Öğe Acute chest syndrome in severity of sickle cell diseases(E-Century Publishing Corp, 2014) Helvaci, Mehmet Rami; Acipayam, Can; Aydogan, Akin; Akkucuk, Seckin; Oruc, Cem; Gokce, CumaliBackground: Sickle cell diseases (SCDs) are chronic inflammatory processes on capillary level. We tried to understand whether or not there are some positive correlations between acute chest syndrome (ACS) and severity of SCDs. Methods: All patients with the SCDs were taken into the study. Results: The study included 337 cases (167 females). There were 15 patients (4.4%) with the ACS. The mean ages were similar in both groups (29.4 versus 29.7 years in the ACS group and other, respectively, P > 0.05). The female ratios were similar in both groups, too (60.0% versus 49.0%, respectively, P > 0.05). Additionally, prevalences of associated thalassemia minors were similar in them (66.6% versus 65.5%, respectively, P > 0.05). Smoking was higher in the ACS group (20.0% versus 13.9%), but the difference was nonsignificant (P > 0.05). Although the mean white blood cell count and hematocrit value of peripheric blood were higher in the ACS group, the mean platelet count was lower in them, but the differences were nonsignificant again (P > 0.05 for all). On the other hand, although the painful crises per year, tonsilectomy, priapism, ileus, digital clubbing, pulmonary hypertension, rheumatic heart disease, cirrhosis, stroke, and mortality were higher in the ACS group, the difference was only significant for the stroke (P < 0.05), probably due to the small sample size of the ACS group. Conclusion: SCDs are chronic destructive processes on capillaries iniatiating at birth, and terminate with early organ failures in life. Probably ACS is one of the terminal consequences of the inflammatory processes that may indicate shortened survival in such patients.Öğe Addition of Ketamine to Propofol-Alfentanil Anesthesia May Reduce Postoperative Pain in Laparoscopic Cholecystectomy(Lippincott Williams & Wilkins, 2013) Karcioglu, Murat; Davarci, Isil; Tuzcu, Kasim; Bozdogan, Yusuf B.; Turhanoglu, Selim; Aydogan, Akin; Temiz, MuhyittinObjective: The aim of this study was to assess whether intravenous anesthesia supplemented with ketamine reduces postoperative pain after elective laparoscopic cholecystectomy. Materials and Methods: Forty patients were enrolled and randomized 1: 1 into one of 2 groups: the propofol group (received propofol and alfentanil supplemented with saline) and the ketamine group (received propofol and alfentanil with ketamine). The study was double-blind. The number and amount of the intraoperative additional alfentanil doses were recorded. Pain assessments and cumulative analgesic consumption at postanesthesia care unit (PACU) admission, PACU discharge, postoperative 24th hour, and hospital discharge were recorded. Results: The visual analog scale scores at PACU admission, PACU discharge, postoperative 24th hour, and hospital discharge were significantly lower in the ketamine group than the propofol group. The pain visual analog scale >= 75 at the postoperative 24th hour for the propofol group was also significantly lower (P < 0.035) than that of the ketamine group. The difference in analgesic consumption between groups was statistically significant (P < 0.001). Conclusions: Our study showed that ketamine supplemented with propofol and alfentanil produced better analgesia intraoperatively and postoperatively and decreased analgesic consumption compared with the propofol group after laparoscopic cholecystectomy.Öğe The Analysis of Mean Platelet Volume and Platelet Distribution Width Levels in Appendicitis(Springer India, 2015) Aydogan, Akin; Akkucuk, Seckin; Arica, Secil; Motor, Sedat; Karakus, Ali; Ozkan, Orhan Veli; Yetim, IbrahimWe aimed to analyze the diagnostic value of mean platelet volume and platelet distribution width, which are also known as the markers of platelet count, in acute and perforated appendicitis. The data of 202 patients who applied to general surgery clinic in Mustafa Kemal University Hospital from 2007 to 2012 with acute appendicitis were analyzed retrospectively. The findings were separated to two groups due to the perforation status (perforated vs. non-perforated). Age, sex, leukocyte, hemoglobin, hematocrit, mean platelet volume, and platelet distribution width were examined. The mean age of the patients was 35.8. Twenty-one of all cases were perforated appendicitis (10.4 %), and the rest was acute appendicitis (non-perforated) (n=181, 89.6 %). The mean platelet volume value was 9.8 +/- 2.1 fL; mean thrombocyte count, 340.9x10(9)/L; and mean platelet distribution width value, 18.3 %. There were statistically significant differences between sex and age, hemoglobin, hematocrit, leukocyte, mean platelet volume, and platelet distribution width. There was a positive correlation between mean platelet volume, platelet distribution width, and platelet. Age, leukocyte, platelet, mean platelet volume, and platelet distribution width were higher in cases with perforation as a comparison with non-perforated cases. We think that mean platelet volume and platelet distribution width may be valuable markers to detect the risk of perforation in early periods of acute appendicitis.Öğe Cholethorax (Bilious Effusion in the Thorax): An Unusual Complication of Laparoscopic Cholecystectomy(Acad Medical Sciences I R Iran, 2013) Aydogan, Akin; Erden, Ersin Sukru; Akkucuk, Seckin; Davran, Ramazan; Yetim, Ibrahim; Ozkan, Orhan VeliCholethorax or bilious effusion in the thorax, is a rare condition in which bile passes into the pleural space from the abdominal cavity, necessitating urgent treatment. In this article, we present a case of cholethorax as a complication of laparoscopic cholecystectomy (LC). The patient underwent a LC due to the presence of a gallbladder polyp. The clip attached to the Hartman opened, and the abdominal cavity became contaminated with binary fluid. Postoperatively, the patient experienced severe right upper quadrant pain and dyspnea. Both the posteroanterior (PA) chest radiography and thoracic computed tomography (CT) were remarkable for marked effusion in the right hemithorax. The patient underwent thoracentesis which resulted in the removal of 250 cc bilious pleural effusion. The bilirubin level of the pleural fluid was 9.1 mg/dL. Following thoracentesis, the patient experienced significant improvement in dyspnea and pain. The patient was discharged without any complications on the seventh day postoperatively. Cholethorax may occur as a result of diaphragmatic injuries secondary to a laparoscopic instrument and can be successfully treated by a thoracentesis.Öğe Colon Perforations Causing Morgagni Hernia Case(Derman Medical Publ, 2014) Ugur, Mustafa; Akkucuk, Seckin; Oruc, Cem; Kayali, Alperen; Aydogan, AkinHerniation of the intraabdominal organs through a diaphragmatic defect that occurs due to the joining anomaly of the sternal and costal segments of diaphragm is known as Morgagni Hernia. Although most of the patients with Morgagni Hernia are asymptomatic, intestinal obstruction, incarceration and strangulation can rarely occur. An 83 years old female patient admitted with acute abdomen to our clinic. Morgagni hernia was detected with preoperative thoracic and abdominal computed tomography. We aimed to present our management in Morgagni Hernia in this study.Öğe Comparison of surgical procedures and percutaneous drainage in the treatment of liver hydatide cysts: a retrospective study in an endemic area(E-Century Publishing Corp, 2014) Akkucuk, Seckin; Aydogan, Akin; Ugur, Mustafa; Yetim, Ibrahim; Davran, Ramazan; Oruc, Cem; Kilic, ErolIntroduction: Surgical procedures are still the golden standard option in the treatment of liver cystic echinococcosis. However, minimal invasive technics like percutaneous drainage are rising trends. We aimed to compare the efficacy of surgical and percutaneous options in the treatment of liver hydatidosis in an endemic area. Methods: Patients who underwent surgical or percutaneous procedures for hydatid disease between January 2007 and December 2012 were retrospectively evaluated. Recurrence rates, hospital stay time, and related factors were analyzed. Results: There were 44 (35.5%) male and 80 (64.5%) female patients in this study. Eighty two patients (Group I) had undergone surgery (66.1%) and 42 patients (Group II) had undergone percutaneous drainage (33.9%). The mean cyst size was 7.28 +/- 2.51 cm in Group I and 8.76 +/- 3.30 cm in Group II. Nine recurrences (7.3%) were detected during study. Five of the recurrences were in Group II (11.9%) and four (4.9%) of them were in Group I. The mean length of hospital stay of all patients was 5.42 +/- 3.16 days. Discussion: Percutaneous drainage techniques can be a good alternative to surgery in selected patients. In complicated cases like cystobiliary fistula, surgery is superior to percutaneous approaches. The hospital stay time, recurrence rate and postoperative complications were not enhanced when compared to percutaneous treatment in our study. Despite all controversy about the low morbidity after percutaneous treatment, surgical approach is still a preferable option in patients with liver hydatidosis when it is performed by experienced surgeons.Öğe Diffuse idiopathic varices in the colon characterized by lower gastrointestinal bleeding(Aves, 2014) Akkucuk, Seckin; Aydogan, Akin; Paltaci, Ilhan; Temiz, MuhiyittinColon varices are very rare lesions that usually present as secondary to portal hypertension. Idiopathic colon varices are even rarer, and should be considered especially in the etiology of massive lower gastrointestinal bleeding. Forty-five year old male presented to our hospital with complaints of recurrent rectal bleeding for one week and severe anemia. The patient was transfused with 4 units of blood. His colonoscopy revealed diffuse submucosal varices. The tests performed for investigation of etiology did not reveal any portal pathology. The patient did not experience another episode of active bleeding during follow-up and was discharged with conservative recommendations. Idiopathic colon varices are rare but should be considered in the differential diagnosis of patients presenting with massive rectal bleeding. Conservative approach is first line of treatment, reserving segmental or total colectomy only for ongoing hemorrhage.Öğe Effect of Radioactive Iodine Therapy on Lacrimal Gland Functions in Patients With Hyperthyroidism(Lippincott Williams & Wilkins, 2014) Aydogan, Fusun; Tuzcu, Esra Ayhan; Aydogan, Akin; Akkucuk, Seckin; Coskun, Mesut; Ustun, Ihsan; Gokce, CumaliBackground Radioactive iodine (RAI) therapy is preferred in the treatment of hyperthyroidism because of its effectiveness, noninvasiveness, and low costs. I-131 has been detected in extrathyroidal tissues, such as in gastric mucosa, salivary glands, and lacrimal glands. To the best of our knowledge, there is no publication concerning the effects of RAI therapy for hyperthyroidism on tear production. In the present study, we evaluated whether or not the lacrimal glands are affected after RAI therapy when compared with pretreatment period. Methods The Schirmer and tear break-up time (TBUT) tests were used to assess 32 eyes of 16 patients with conditions that were diagnosed as hyperthyroidism before and at 3 and 6 months after RAI treatment. In addition, pretreatment values of patients were compared with that of controls. It was evaluated whether or not a correlation exists between the results and the dose or iodine uptake values. Results There was no significant difference between pretreatment values of Schirmer and TBUT tests obtained in the patient group and those of the control group (P > 0.05). In the patient group, there was a significant difference between the posttreatment and pretreatment values (P < 0.05). There was a positive correlation between uptake values obtained at 24 hours and the values obtained by TBUT and Schirmer tests on both eyes at 3 and 6 months. At 6 months, the uptake value at 24 hours was 28.83 +/- 60 for both eyes in patients with TBUT test values less than 10, whereas it was 39.25 +/- 7.88 for the right eye and 39.00 +/- 6.85 for the left eyes in patients with TBUT test values greater than 10. The difference was statistically significant (P < 0.05). Conclusions In our study, we concluded that the decrease in mucin and aqueous production occurs due to affected lacrimal glands by RAI therapy; however, this effect is not dose dependent.Öğe The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer(Termedia Publishing House Ltd, 2013) Tutanc, Oznur Donmez; Aydogan, Akin; Akkucuk, Seckin; Sunbul, Ahmet Taner; Zincircioglu, Seyit Burhanedtin; Alpagat, Gulistan; Erden, Ersin SukruAim of the study: This study explores the efficacy of oral glutamine in the prevention of acute radiotherapy-induced esophagitis in patients with lung cancer who are treated with thoracic radiotherapy. Material and methods: This study was planned as a retrospective randomized experimental study. Forty-six patients with lung cancer, who were treated and kept under control between January 2008 and January 2010, were included in the study by the Department of Radiation Oncology, Faculty of Medicine, Dicle University. The patients were divided into two groups. The first group (n = 21) was given prophylactic oral powder glutamine (daily 30 g), while the second group (n = 25) was not given oral glutamine. Results: There were 21 patients in Group 1 (45.7%) and 25 patients in Group 2 (54.3%). No significant statistical difference was observed between the two groups in terms of age, gender, stage, histopathological type, treatment choice, received radiation doses, esophagus length in RI field, or location of the tumor (p > 0.05). A significant statistical difference was observed between the glutamine-supplemented group (first group) and the glutamine:free group (second group) according to the grade of esophagitis (p < 0.0001). Conclusions: In our retrospective randomized experimental study, we determined that the severity of acute radiotherapy-induced esophagitis might be decreased with oral glutamine in patients with lung Cancer who were treated with thoracic radiotherapy.Öğe Gossypiboma Causing Mechanical Intestinal Obstruction: A Case Report(Hindawi Ltd, 2012) Aydogan, Akin; Akkucuk, Seckin; Yetim, Ibrahim; Ozkan, Orhan Veli; Karcioglu, MuratIntroduction. Gossypiboma (GP) is a term used to express the mass resulting from forgotten cotton sponge in operations. Rarely, a transmural migration may occur into the gastrointestinal lumen without creating any defect by GP. Laparotomy or endoscopic removal may be required, by the way it can be taken out of the body itself by intestinal ways. In this study, we reported a case of mechanical intestinal obstruction causing GP. Case. The fifty-one-year-old female patient admitted to the emergency department with the complaints of mechanical intestinal obstruction and had a history of open cholecystectomy 20 years ago. There were the findings of intestinal obstruction in abdominal plain radiography and computerized tomography. The sponge that obstructed the lumen completely 40 cm proximal to the ileocecal valve was identified in the laparotomy with the diagnosis of brid ileus. The small intestine was closed over double-fold after removal of sponge. Transmural migration of abdominal-remained sponge was thought to be occurred without creating a defect after cholecystectomy. Postoperatively, the patient was discharged without having any problems at 4th day of hospitalization. Conclusion. Although it is a rare situation in routine clinical practice, GP should be considered as a differential diagnosis in the patients who had a diagnosis of mechanical intestinal obstruction, and laparotomy was applied before. As GP may lead to situations which cause mortality, all precautions should be taken to prevent it.Öğe Left Inguinal Bladder Hernia That Causes Dilatation in the Ureter(Acad Medical Sciences I R Iran, 2016) Ugur, Mustafa; Atci, Nesrin; Oruc, Cem; Akkucuk, Seckin; Aydogan, AkinThe scrotal bladder hernia is a rare condition that may present a scrotal swelling and urinary system obstruction or in Diagnosis of this condition before the operation decreases the severe complications like bladder, injury during operation. In this article, a 75-year-old man presented to our clinic with right inguinal swelling and lower urinary system infection hernia was diagnosed after performing a computed tomography. The hernia was repaired without any complications.Öğe Left inguinal bladder hernia that causes dilatation in the ureter(Academy of Medical Sciences of I.R. Iran, 2016) Ugur, Mustafa; Atcı, Nesrin; Oruc, Cem; Akkucuk, Seckin; Aydogan, AkinThe scrotal bladder hernia is a rare condition that may present as scrotal swelling and urinary system obstruction or infection symptoms. Diagnosis of this condition before the operation decreases the severe complications like bladder injury during operation. In this article, a 75-year-old man presented to our clinic with right inguinal swelling and lower urinary system infection. Inguinal bladder hernia was diagnosed after performing a computed tomography. The hernia was repaired without any complications. © 2016, Academy of Medical Sciences of I.R. Iran. All rights reserved.Öğe A new treatment approach in tuberculosis(Medi+World Int, 2013) Helvaci, Mehmet Rami; Akkucuk, Seckin; Aydogan, AkinRole of total excision of lymphadenopathies (LAPs) if they are limited in number is unknown in the treatment of tuberculosis (TB). A 14-year old male applied with weight loss. On physical examination, there were multiple right axillary LAPs with sizes of 3x2 cm. In laboratory examination, C-reactive protein (CRP) was 2.1 mg/dL, erythrocyte sedimentation rate (ESR) was 73 mm/hr, and lactate dehydrogenase (LDH) was 250 IU/L. Tuberculin skin test showed a 22 mm of induration. The right axillary LAPs were excised, totally, and histological examination demonstrated granulomas with Langhans-type giant histiocytes. After the operation, ESR, CRP, and LDH values and his weight returned to normal without any treatment. Secondly, a 43year old female applied with fever, night sweats, and weight loss. On physical examination, there were multiple and conglomerated left axillary LAPs with sizes of 6x4 cm. In laboratory examination, CRP was 5.2 mg/dL, ESR was 74 mm/hr, and LDH was 329 IU/L. Tuberculin skin test showed a 20 mm of induration. The LAPs were excised, totally, and histological examination demonstrated granulomatous lymphadenitis with epitheloid histiocytes, Langhanstype giant cells, and caseified necrosis. After the operation, fever and night sweats disappeared, and CRP, ESR, and LDH values were normalized. She returned to normal weight within two months without any antituberculous treatment. As a conclusion, total excision of LAPs if they are limited in number may both have a diagnostic and curative role in TB, probably by decreasing large numbers of bacteria, so remaining small numbers can be eliminated by immune system, alone.Öğe THE PROTECTIVE EFFECTS OF PEPTIDE YY AND GHRELIN IN ACUTE BILIARY PANCREATITIS(Carbone Editore, 2014) Aydogan, Akin; Akkucuk, Seckin; Ozkan, Orhan Veli; Aydin, Mehmet; Motor, Sedat; Ugur, Mustafa; Oruc, CemAim: Glzrelin and peptide YY are gut hormones that have an anti-inflammatory effect by inhibiting proinflammatory cytokines. We aimed to determine the anti-inflammatory and protective effects of ghrelin and Peptide YY. Methods: The study group included 28 patients with acute biliary pancreatitis and 38 controls. Ghrelin, peptide YY, IL-6, TNF-alpha, amylase, lipase, glucose, alanine aminotransferase, aspartate aminotransferase, leucocyte count, and hematocrit were measured three times in each patient and once in the control group. Results: Ghrelin levels tended to increase as treatment continued, but still were below the levels in the control group. On the other hand, peptide YY levels in all of the patient samples were higher than in the control group (p>0.001). Conclusion: Ghrelin is proposed as a protective hormone for acute pancreatitis. Exogenous ghrelin exhibits protective activity in caerulein-induced pancreatitis. All previous in vivo and in vitro studies have reported that exogenous PYY administration inhibited izzflammation and had protective effects. This study indicates for the first time that endogenous PYY has protective effects on pancreatitis via the inhibition of inflammation, and that these effects are stronger than the effects of ghrelin.Öğe The protective effects of peptide YY and ghrelin in acute biliary pancreatitis(Acta Medica Mediterranea, 2014) Aydogan, Akin; Akkucuk, Seckin; Ozkan, Orhan Veli; Aydin, Mehmet; Motor, Sedat; Ugur, Mustafa; Oruc, CemAim: Ghrelin and peptide YY are gut hormones that have an anti-inflammatory effect by inhibiting proinflammatory cytokines. We aimed to determine the anti-inflammatory and protective effects of ghrelin and Peptide YY. Methods: The study group included 28 patients with acute biliary pancreatitis and 38 controls. Ghrelin, peptide YY, IL-6, TNF-?, amylase, lipase, glucose, alanine aminotransferase, aspartate aminotransferase, leucocyte count, and hematocrit were measured three times in each patient and once in the control group. Results: Ghrelin levels tended to increase as treatment continued, but still were below the levels in the control group. On the other hand, peptide YY levels in all of the patient samples were higher than in the control group (p>0.001). Conclusion: Ghrelin is proposed as a protective hormone for acute pancreatitis. Exogenous ghrelin exhibits protective activity in caerulein-induced pancreatitis. All previous in vivo and in vitro studies have reported that exogenous PYY administration inhibited inflammation and had protective effects. This study indicates for the first time that endogenous PYY has protective effects on pancreatitis via the inhibition of inflammation, and that these effects are stronger than the effects of ghrelin.Öğe Protective effects of tirofiban hydrochloride, a glycoprotein IIb/IIIa inhibitor, on liver ischemia/reperfusion injury in rats(Acta Medica Mediterranea, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, ZaferAims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein IIb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60- minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.Öğe PROTECTIVE EFFECTS OF TIROFIBAN HYDROCHLORIDE, A GLYCOPROTEIN IIB/IIIA INHIBITOR, ON LIVER ISCHEMIA/REPERFUSION INJURY IN RATS(Carbone Editore, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, ZaferAims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein Ilb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60-minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.Öğe A Rare Cause of Small Bowel Perforation; Tree Branches Ingested: A Case Report(Derman Medical Publ, 2015) Oruc, Cem; Ugur, Mustafa; Akkucuk, Seckin; Aydogan, AkinIngestion of foreign bodies, especially, is more common among children, prisoners, alcoholics, psychiatric patients and the elderly. The majority of ingested foreign bodies pass through the intestinal tract causing perforation less than 1%. Sharp and pointed foreign bodies cause small bowel perforation more frequently than round-tipped objects. In this article, we present a small bowel perforation case of 16 year-old mentally retarded male patient that underwent surgery for the third time for swallowing a number of tree branches who had been undergone two operations previously due to foreign bodies ingestion.Öğe Safety and efficacy of tirofiban hydrochloride (TH) in cerulein-induced acute pancreatitis(A. CARBONE Editore, 2015) Kaplan, Aydin; Akkucuk, Seckin; Ugur, Mustafa; Aydogan, Akin; Ozgur, Tumay; Caliskan, Yasemin; Yetim, IbrahimIntroduction: Tissue perfusion plays an important role in pancreatitis. Free oxygen radicals also have some triggering roles in the severity of acute pancreatitis. Tirofiban hydrochloride (TH) is being used for ischemic disorders for many years and is known as an antiaggregant drug. We aimed to determine the therapeutic effects of tirofiban in cerulein-induced acute pancreatitis in this animal study. Materials and methods: Twenty-four Wistar-Albino male rats were divided into three equal groups; Group I: Sham-operated group, Group II: cerulein induced pancreatitis group, Group III: cerulein induced pancreatitis + treatment group (intraperitoneal 0.25 mg tirofiban hydrochloride in 1 ml isotonic saline solution). Amylase and lipase levels were studied in blood samples and malondialdehyde, glutathione peroxidase and superoxide dismutase activities were measured in tissue samples. Results: Amylase and lipase levels were elevated in acute pancreatitis group. The levels of both enzymes were decreased after the rats were medicated with TH. Malondialdehyde (MDA) was higher in pancreatitis group without treatment. There were no significant differences between groups according to glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels. Conclusion: The present findings suggest that TH has an antiaggregant effect and may reduce the progression and improve the healing of acute pancreatitis.Öğe SAFETY AND EFFICACY OF TIROFIBAN HYDROCHLORIDE (TH) IN CERULEIN-INDUCED ACUTE PANCREATITIS(Carbone Editore, 2015) Kaplan, Aydin; Akkucuk, Seckin; Ugur, Mustafa; Aydogan, Akin; Ozgur, Tumay; Caliskan, Yasemin; Yetim, IbrahimIntroduction: Tissue perfusion plays an important role in pancreatitis. Free oxygen radicals also have some triggering roles in the severity of acute pancreatitis. Tirofiban hydrochloride (TH) is being used for ischemic disorders for many years and is known as an antiaggregant drug. We aimed to determine the therapeutic effects of tirofiban in cerulein-induced acute pancreatitis in this animal study. Materials and methods: Twenty-four Wistar-Albino male rats were divided into three equal groups; Group I: Sham-operated group, Group II: cerulein induced pancreatitis group, Group III: cerulein induced pancreatitis + treatment group (intraperitoneal 0.25 mg tirofiban hydrochloride in 1 ml isotonic saline solution). Amylase and lipase levels were studied in blood samples and malondialdehyde, glutathione peroxidase and superoxide dismutase activities were measured in tissue samples. Results: Amylase and lipase levels were elevated in acute pancreatitis group. The levels of both enzymes were decreased after the rats were medicated with TH. Malondialdehyde (MDA) was higher in pancreatitis group without treatment. There were no significant differences between groups according to glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels. Conclusion: The present findings suggest that TH has an antiaggregant effect and may reduce the progression and improve the healing of acute. pancreatitis.
