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  • Küçük Resim
    Öğe
    The effects of zoledronic acid on neointimal hyperplasia : a rabbit carotid anastomosis model - Original Investigation
    (2011) Güzeloğlu, Mehmet; Gül, Mehmet; Reel, Buket; Yürekli, İsmail; Aykut, Koray; Hazan, Eyüp
    Objective: The aim of the present study was to investigate the effect of zoledronic acid (ZA), as a matrix metalloproteinase inhibitor, on neointimal hyperplasia in rabbit carotid anastomosis model. Methods: New Zealand male rabbits were divided into two groups as placebo and treatment groups in this experimental study. After anesthesia, the right carotid artery of each rabbit was end-to-end anastomosed with an 8/0 polypropylene suture. Left carotid artery was kept as control without any operation. Placebo group (n=6) received phosphate buffered saline (PBS) (0.5mL/kg/day/s.c.) for 28 days postoperatively, whereas ZA group (n=6) received ZA (100 µg/kg/day/s.c.) for the same period. After sacrification, the anastomosed and control arteries were isolated. Morphometric and immunohistochemical examinations were performed. Statistical analyses of morphometric and immunohistochemical data were performed using two-way ANOVA and Chi-square test respectively. Results: In PBS group, vascular injury in the anastomosed artery significantly increased the intimal area (anastomosed: 112.51±61.18 µm2*1000 vs. control: 22.62±4.26µm2*1000, p<0.01) and intima/media index (anastomosed: 0.347±0.29 vs. control: 0.075±0.01, p<0.05) compared to control artery. ZA significantly reduced the intimal area (39.29±18.21 µm2*1000 , p<0.01) and intima/media index (0.112±0.07, p<0.05) compared to PBS group. Additionally, &#945;-smooth muscle actin immunopositivity was found significantly decreased in anastomosed arteries from ZA group (ZA: 2.33±0.52 vs. PBS: 3.50±0.5, p<0.05). Moreover, intensive gelatinase (MMP-2 and MMP-9) immunoreactivities were clearly seen in anastomosed arteries compared to control arteries from PBS group. ZA apparently decreased immunopositivities for gelatinases in anastomosed arteries. Conclusion: ZA might be a promising agent for prevention of neointimal hyperplasia, which is the most significant cause of graft failures in late postoperative period.
  • Küçük Resim
    Öğe
    İntravenöz ilaç bağımlılığına bağlı sol femoral psödoanevrizma : olgu sunumu
    (2017) Fansa, İyad; Çalışkan, Koca; Altınay, Levent; Güzeloğlu, Mehmet; Küçüker, Şeref Alp
    Arteriyel psödoanevrizmalar özellikle periferik vasküler yapıların çeşitli nedenlerle travmatize olması sonucu meydana gelebilir. İntravenöz ilaç kullanımı bu nedenlerden biridir. Ulaşılması ve intravenöz enjeksiyonu kolay olduğu için femoral bölgeyi tercih eden intravenöz ilaç bağımlılarında enfekte psödoanevrizma görülebilir. Bu yazıda, bir intravenöz ilaç bağımlısında sol femoral bölgede tekrarlayan enjeksiyonlar sonrasında meydana gelen enfekte femoral psödoanevrizma sunuldu