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    Does helicobacter pylori cause psychiatric symptoms in dyspeptic patients?
    (Acta Medica Mediterranea, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, Eray
    Objective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not. In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-compulsive features, sensibility in interpersonal relations, anxiety, anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group got higher scores from the sub-groups of anxiety, obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index , the HP (-) group got higher scores from sub-scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub-scale are above eleven, which is cutoff score. Besides the group with HP (+) has been detected to get a score over 1 from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms. Individuals who suffer from dyspepsia had better get examined.
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    DOES HELICOBACTER PYLORI CAUSE PSYCHIATRIC SYMPTOMS IN DYSPEPTIC PATIENTS?
    (Carbone Editore, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, Eray
    Objective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-coin. pulsive features, sensibility in interpersonal relations anxiety anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group :got higher scores from the sub groups of anxiety, Obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index, the HP (-) group got higher scores from sub scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub scale are above eleven;. which is cutoff score. Besides the group with Hp (+) has been detected to get a score. over I from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms: Individuals who suffer from dyspepsia had better get examined.
  • Küçük Resim
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    The Effect of Agomelatine on the Nociceptive System
    (Kure Iletisim Grubu A S, 2014) Kivrak, Yuksel; Karademir, Basaran; Aygun, Hayati; Ersan, Yusuf; Ari, Mustafa; Karaahmet, Elif; Yagci, Ibrahim
    Objective:The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive. system. Methods: Twenty four male Swiss albino mice (four months old and 28.8 +/- 1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50 degrees C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings. Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036). Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.
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    Increased Mean Platelet Volume in Patients with Depression
    (Derman Medical Publ, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal Turker; Kivrak, Yuksel
    Aim: It is well known that the mean platelet volume (MPV) is a good indicator of platelet activity and the incidence of cardiovascular diseases. Major depressive disorder may emerge in association with the cardiovascular diseases. In this study, we aimed to investigate the relationship between MPV and major depressive disorder. Material and Method: MPV values of 65 patients with major depression were compared with 66 age-and sex-matched healthy subjects. Body mass index (BMI), MPV, platelet count (PLC) of all participants were measured. Beck Depression Scale (BDS) was performed to measure severity of depression. Results: MPV values of patients who had major depression were found to be significantly higher than the control group. Comparing Major Depression with the control group, there was no significant difference in terms of platelet count. In the depression group, there was no correlation between the severity of depression and MPV. Discussion: As a result, the mean platelet volume was determined to have a significant increase in major depressive disorder compared with healthy individuals. This also may be informative about the association between pathologies related vascular structure such as vascular atherosclerosis and depression.
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    Increased mean platelet volume in patients with panic disorder
    (Dove Medical Press Ltd, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Kivrak, Yuksel; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal Turker
    Objective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age-and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.
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    Low adiponectin and high resistin levels in panic disorder
    (Informa Healthcare, 2012) Bez, Yasin; Bulut, Mahmut; Kivrak, Yuksel; Cemal, Kaya Mehmet; Muharrem, Yunce; Mustafa, Ari; Hasan, Ozturk Oktay
    [Abstract Not Available]
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    Partner violence against women, childhood trauma, depression and quality of life: a population based-study
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Kivrak, Yuksel; Gey, Neriman; Kivrak, Habibe Ayla; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, Mustafa
    Objective: In this study our aim was to investigate the frequency of spousal violence, its relationship with childhood traumas, depression and sociodemographic factors and its effects on affected women's life quality. Methods: Data of 410 randomly chosen people who live in the city center and nearby villages were evaluated. The sociodemographic data survey, Short Form 36 (SF- 36), Family Violence Survey (FVS), Beck Depression Scale (BDS), Childhood Trauma Scale (CTS) were applied. Results: Of the participants, 366 (89.3%) had experienced violence at least once in their lifetime. 309 (75.4%) of them were emotional, 306 (74.6%) of them were sexual, 285 (69.5%) of them were verbal, 222(54.1%) of them were physical, 321 (78.3%) of them were economical violence. Beck Depression Scale, Childhood Trauma Scale, husband's educational level, disparity in age and education level between spouses were important for exposure to violence. Depression was an important effect on life quality of the affected women. Conclusion: Familial violence is frequent. BDS, CTS are the main predictors for spousal violence and life quality. Diagnosis and treatment of depression may help to prevent spousal violence and increase life quality.
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    SmartClamp circumcision versus conventional dissection technique in terms of parental anxiety and outcomes: A prospective clinical study
    (Canadian Urological Association, 2015) Karadag, Mert Ali; Cecen, Kursat; Demir, Aslan; Kivrak, Yuksel; Bagcioglu, Murat; Kocaaslan, Ramazan; Ari, Mustafa
    Introduction: We prospectively analyzed parental anxiety and outcomes of the SmartClamp circumcision and the classic surgical dissection technique. Methods: A total of 250 boys underwent circumcision between 2009 and 2012 at Kars State Hospital and Kafkas University Faculty of Medicine in Turkey. The initial 125 children were circumcised by conventional dissection method and the remaining children were operated on with a SmartClamp device. Children in both groups were compared in terms of bleeding, infection, penile edema, operative time, cosmetic result, length of the inner mucosal layer, and parental anxiety. We used a State-Trait Anxiety Inventory (STAI) form to gauge how the circumcision affected parental anxiety. This form was completed by parents on postoperative day 2. Results: There were no statistically significant differences among the 2 groups in terms of age, bleeding, infection, and cosmetic displeasure (p > 0.05). The STAI scores of the parents from the SmartClamp group were statistically higher than that of the other group (p < 0.001). Penile edema was more common in the SmartClamp group (p = 0.039). However, the mean operative time was statistically shorter (p < 0.001) and the inner mucosal length was significantly longer in the SmartClamp group (p < 0.001). Conclusion: Circumcision with the SmartClamp device was faster. Cosmetic results and complication rates were similar. Unfortunately, this technique seemed to entail the disadvantages of longer mucosal length, penile edema, and higher parental anxiety. Urologists should keep these points in mind when choosing a technique.
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    Stress reaction, anxiety and depression after bomb attacks in Reyhanli in Syria-Turkey border
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Ari, Mustafa; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Yengil, Erhan; Kivrak, Yuksel; Sahpolat, Musa; Budak, Birsen
    Objective: Terror attacks are actions taken to create maximum negative psychological impact on the target population. As result of two separate bombings on 11 March 2013 at Hatay, Reyhanli 52 people died and 146 people were injured. The purpose of this study is to determine the ratio of depression, anxiety and post-traumatic stress disorder (PTSD) on sixth month following the blast in those people who were exposed to explosions either visually and auditory, and in tose who were lindirectly exposed by being witnesses. Methods: In this study 43 people who were directly exposed, 42 people who were indirectly exposed to the explosions and 45 healthy people as a control group are included for a total of 130 individuals. On sixth month after the blast Beck Depression Inventory, Civilian Versions of Post-traumatic Stress Disorder Checklist, State-Trait Anxiety Inventory and Sociodemographic Information Form were administered to all subjects. Results: The prevalence of depression, anxiety and post-traumatic stress disorder on people who directly and indirectly exposed to explosions are significantly high compared to control group. Among the three groups there are no statistically significant differences in terms of age, gender and demographic factors. Conclusions: Our study has supportive information about the individuals who were exposed to terrorist attacks have high prevalence of PTSD. Additionally, the fact that the prevalence of PTSD and depression were higher in directly exposed cases than indirectly exposed ones may be illustrative in terms of approach to terror trauma.