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Öğe Basal Septal Hypertrophy as the Early Imaging Biomarker for Adaptive Phase of Remodeling Prior to Heart Failure(Mdpi, 2022) Yalcin, Fatih; Yalcin, Hulya; Kucukler, Nagehan; Arslan, Serbay; Akkus, Oguz; Kurtul, Alparslan; Abraham, Maria RoselleHypertension plays a dominant role in the development of left ventricular (LV) remodeling and heart failure, in addition to being the main risk factor for coronary artery disease. In this review, we focus on the focal geometric and functional tissue aspects of the LV septal base, since basal septal hypertrophy (BSH), as the early imaging biomarker of LV remodeling due to hypertensive heart disease, is detected in cross-sectional clinic studies. In addition, the validation of BSH by animal studies using third generation microimaging and relevant clinical observations are also discussed in the report. Finally, an evaluation of both human and animal quantitative imaging studies and the importance of combined cardiac imaging methods and stress-induction in the separation of adaptive and maladaptive phases of the LV remodeling are pointed out. As a result, BSH, as the early imaging biomarker and quantitative follow-up of functional analysis in hypertension, could possibly contribute to early treatment in a timely fashion in the prevention of hypertensive disease progression to heart failure. A variety of stress stimuli in etiopathogenesis and the difficulty of diagnosing pure hemodynamic overload mediated BSH lead to an absence of the certain prevalence of this particular finding in the population.Öğe BASAL SEPTAL HYPERTROPHY IN ADAPTIVE PHASE OF REMODELLING AND INTRACAVITARY GRADIENTS(Elsevier Science Inc, 2023) Yalcin, Fatih; Cagatay, Boran; Kucukler, Nagehan; Marangozoglu, Yusuf; Yalcin, Hulya[Abstract Not Available]Öğe Could early septal involvement in the remodeling process be related to the advance hypertensive heart disease?(Elsevier Ireland Ltd, 2015) Yalcin, Fatih; Topaloglu, Caner; Kucukler, Nagehan; Ofgeli, Mehmet; Abraham, Theodore P.Background: Quantitative imaging analyses showed an earlier septal wall involvement in hypertension. We planned to determine the effect of hypertension on regionalmyocardial performance index (MPI) in a hypertensive patient population. Methods: We evaluated 119 hypertensive patients who were divided into gr. I:57 patients without left ventricular hypertrophy (LVH), (53.1 +/- 10 years), and gr.II:62 patients with LVH (55.1 +/- 9 years) using conventional and tissue doppler imaging. They were compared with gr. III, a sex-age-matched normal control group (37 subjects, 53.0 +/- 10 years). Results: We detected basal septal and basal lateral contraction time (CT), isovolumetric CT and relaxation time (IVRT) and MPI. EF was 68 +/- 5 % in gr. I, 69 +/- 5 % in gr. II, 69 +/- 4 % in gr. III. LV mass index was 122 +/- 11 g/m2 in gr. I, 148 +/- 13 g/m2 in gr. II and 118 +/- 13 g/m2 in gr. III. Concentric LVH was detected in gr. II (relative wall thickness=0.49 +/- 0.8). LV septal and lateral MPI were abnormal in both hypertensive groups (p < 0.0001). Septal MPI was correlated moderately with septal wall thickness (r = 0.447, p < 0.001). Conclusions: LV diastolic dysfunction becomes more severe in septal wall than lateral wall in hypertensive LVH. Septal myocardial performance is more dominantly affected by hypertension possibly due to earlier septal involvement in disease course. Septal MPI is correlated moderately with septal wall thickness. (C) 2015 Published by Elsevier Ireland Ltd.Öğe The effect of valsartan on left ventricular myocardial functions in hypertensive patients with left ventricular hypertrophy(Lippincott Williams & Wilkins, 2012) Kucukler, Nagehan; Kurt, Ibrahim H.; Topaloglu, Caner; Gurbuz, Suleyman; Yalcin, FatihBackground It has been shown by various diagnostic methodologies that angiotensin receptor blockage reduces left ventricular mass, improves diastolic function and increases contractility in hypertensive left ventricular hypertrophy (LVH). We planned to detect the effect of angiotensin receptor blockage on midwall mechanics and myocardial dynamics in hypertensive patients with LVH. Methods Angiotensin 2 type 1 receptor blocker (valsartan 80-160 mg) was administered to 38 previously untreated hypertensive patients with LVH for 6 months. Left ventricular midwall mechanics and tissue Doppler velocities were measured at baseline and at the end of the study. Results: Mean blood pressure was reduced from 152 +/- 14/92 +/- 8 to 131 +/- 14/83 +/- 9 mmHg (P<0.05). Left ventricular mass index was decreased from 135 +/- 15 to 114 +/- 14 g/m(2) (P<0.001). Midwall fractional shortening was increased from 19.0 +/- 4 to 22.4 +/- 3% (P<0.05). Circumferential end-systolic wall stress was decreased from 131 +/- 44 to 119 +/- 37 X 10(3) dyn/cm(2) (P<0.05). Left ventricular interventricular septal myocardial tissue peak systolic velocity was increased from 6.7 +/- 1 to 8.1 +/- 0.9 cm/s (P<0.001) and lateral wall myocardial tissue peak systolic velocity was increased from 7.5 +/- 1 to 9.0 +/- 1 cm/s (P<0.001), and E/E-m ratio was significantly decreased (11.0 +/- 0.3 to 8.90 +/- 0.1, P<0.05) with 6-month valsartan therapy. Conclusion This study suggests that valsartan exhibits not only blood pressure-lowering qualities but also cardioprotective actions in patients with hypertension because it enhances regression of LVH and improves left ventricular myocardial contractility and relaxation.Öğe EVALUATION OF REGIONAL MYOCARDIAL DYNAMICS IN LEFT VENTRICULAR HYPERTROPHY SECONDARY TO ESSENTIAL HYPERTENSION(Elsevier Science Inc, 2011) Yalcin, Fatih; Kucukler, Nagehan; Haq, Nowreen; Abraham, Theodore P.[Abstract Not Available]Öğe Geomeric and functional aspects in hypertension and takotsubo: importance of basal septal hypertrophy(Oxford Univ Press, 2023) Yalcin, Fatih; Cagatay, Boran; Kucukler, Nagehan; Abraham, Theodore P.[Abstract Not Available]
