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Öğe Abdominal Pain and Confusion: A Case Report of Abdominal Epilepsy(Kare Publ, 2015) Kuvandik, Guven; Karakus, Ali; Sahan, Mustafa; Ozcan, OguzhanAbdominal epilepsy is a recurrent and rare condition characterized by gastrointestinal symptoms such as abdominal pain, nausea, vomiting and neurological findings such as lethargy and convulsion. Although usually seen in childhood, it can also be seen in adults. After ruling out more common causes of abdominal pain, it is diagnosed with electroencephalography (EEG). The improvement of symptoms with antiepileptics is important in diagnosis. A 17-year-old woman was admitted to the emergency department with sudden loss of consciousness. On admission, general condition of the patient was moderate. The patient had confusion, and her other vital signs were as follows: Glasgow Coma Scale (GCS) at 11 (E: 2M: 5V: 4); arterial blood pressure, 100/60 mmHg; heart rate, 100 beats/min; respiration rate, 20 breaths/min and temperature, 37.2 degrees C. Other physical examination findings were normal. First serum glucose level was 85 mg/dL. Serum amylase, lipase and other laboratory test results were within normal limits. After two hours of monitoring, her consciousness was completely opened. For differential diagnosis of abdominal pain, control results were normal. There was not any abnormal findings in computed tomography (CT) scans of brain. In EEG recordings, moderately active epileptiform abnormalities were detected. Levetirasetam medication was initiated. There were no problems observed during the one-year treatment period. Abdominal epilepsy is a rare condition that should be considered in patients presented with abdominal pain and confusion. After the initial tests performed for differential diagnosis of abdominal pain, patients should be evaluated with EEG.Öğe Accelerated atherosclerosis and digital clubbing in sickle cell diseases(Medi+World Int, 2016) Helvaci, Mehmet Rami; Sahan, Mustafa; Sulhan, Agit; Acik, Abdullah Fatih; Ocak, Adil; Salaz, Semih; Pocock, LesleyBackground: Sickle cell diseases (SCDs) are chronic destructive processes mainly on the capillary endothelium. We tried to understand the significance of digital clubbing in severity of SCDs. Methods: All patients with SCDs were taken into the study. Results: The study included 397 patients (193 females). There were 36 cases (9.0%) with digital clubbing. Male ratio was significantly higher in the digital clubbing group (66.6% versus 49.8%, p<0.05). The mean age was significantly higher in the digital clubbing group, too (36.5 versus 29.0 years, p=0.000). Additionally, smoking was also higher in the digital clubbing group, significantly (30.5% versus 11.0%, p<0.001). The mean white blood cell counts of peripheric blood were similar in both groups (p<0.05). On the other hand, the mean hematocrit value and platelet count of peripheric blood were lower in the digital clubbing group, significantly (p=0.001 and p=0.012, respectively). Beside that, prevalence of leg ulcers, pulmonary hypertension, chronic obstructive pulmonary disease, coronary heart disease, cirrhosis, and stroke were significantly higher in the digital clubbing group (p<0.01 for all). There were 25 mortalities during the period, and 13 of them were males. The mean ages of mortality were 33.0 +/- 9.6 (range 1947) in females and 30.0 +/- 8.6 years (range 19-50) in males. Conclusion: SCDs are chronic destructive processes on endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Probably digital clubbing is one of the terminal consequences of the SCDs indicating significantly shortened survival in such patients.Öğe A Case of Ecstacy Induced Rhabdomyolysis and Acute Renal Failure(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2016) Sahan, Mustafa; Turgut, Faruk; Eren, Abdulrahim; Duru, Mehmet3,4-methylenedioxymethamphetamine (MDMA), popularly known as ecstasy, is a synthetic, psychoactive drug. MDMA has been reported to have several severe adverse effects including rhabdomyolysis, acute renal failure, liver failure and even sudden death. Herein, we present the case of a young man who presented with severe rhabdomyolysis and renal failure after taking 2 ecstasy pills. The patient initially received supportive care but he eventually needed hemodialysis.Öğe Colonoscope incarceration in an inguinal hernia: a complication of colonoscopy(Georg Thieme Verlag Kg, 2015) Tas, Adnan; Oruc, Cem; Olmez, Sehmus; Sahan, Mustafa; Ugur, Mustafa; Hakimoglu, Sedat; Demir, Mehmet[Abstract Not Available]Öğe DEMOGRAPHIC, CLINIC AND LABORATORY CHARACTERISTICS OF CASES PRESENTED TO EMERGENCY DEPARTMENT WITH SCORPION STING: 345 CASES OVER A 4-YEARS PERIOD(Carbone Editore, 2013) Duru, Mehmet; Karakus, Ali; Yengil, Erhan; Sahan, Mustafa; Zeren, Cem; Kekec, Zeynep; Yagiz, Abdullah ErmanIntroduction: In the scorpion stings, based on the involved system, clinical and laboratory changes may be seen in a wide spectrum from mild pain and flushing to death. The present study was aimed to assess patient demographics, clinical characteristics and outcomes. Methods:All patients presented to emergency department with scorpion sting between 2008 and 2011 were retrospectively evaluated by using electronic database. Results: Overall, 345 cases were included into the study, consisting of 160 male (46.4%) and 185 female (53.6%) with a mean age of 34.39 +/- 19.47 years. It was found that scorpion sting patients were most commonly stung at extremities (n=322; 93.3%). The most commonly observed complaint was pain (n=334; 96.8%).Localized flushing and edema were observed in 307 cases (89.0%). In the laboratory evaluation, it was found that mean values of complete blood counts, biochemistry assays and prothrombin time (PT). international normalized ratio (INR) and partial thromboplastin time (PTT) were within normal range. Of the cases, 99.4%(n=343) were discharged, while two children (0.6%) died due to cardiac and respiratory complications. Conclusions: Since complete blood count and coagulation assays may be normal, these assays aren't routinely needed in all cases with scorpion sting. Anti-serum therapy should be considered at early course of the disease in children and elderly patients due to complications and mortality; it should be intravenously administered V indicated, but it should not be used in all patients.Öğe Demographic, clinic and laboratory characteristics of cases presented to emergency department with scorpion sting: 345 cases over a 4-years period(Acta Medica Mediterranea, 2013) Duru, Mehmet; Karakus, Ali; Yengil, Erhan; Sahan, Mustafa; Zeren, Cem; Kekec, Zeynep; Yagiz, Abdullah ErmanIntroduction: In the scorpion stings, based on the involved system, clinical and laboratory changes may be seen in a wide spectrum from mild pain and flushing to death. The present study was aimed to assess patient demographics, clinical characteristics and outcomes. Methods:All patients presented to emergency department with scorpion sting between 2008 and 2011 were retrospectively evaluated by using electronic database. Results: Overall, 345 cases were included into the study, consisting of 160 male (46.4%) and 185 female (53.6%) with a mean age of 34.39±19.47 years. It was found that scorpion sting patients were most commonly stung at extremities (n=322; 93.3%).The most commonly observed complaint was pain (n=334; 96.8%).Localized flushing and edema were observed in 307 cases (89.0%). In the laboratory evaluation, it was found that mean values of complete blood counts, biochemistry assays and prothrombin time (PT), international normalized ratio (INR) and partial thromboplastin time (PTT) were within normal range. Of the cases, 99.4%(n=343) were discharged, while two children (0.6%) died due to cardiac and respiratory complications. Conclusions: Since complete blood count and coagulation assays may be normal, these assays aren't routinely needed in all cases with scorpion sting. Anti-serum therapy should be considered at early course of the disease in children and elderly patients due to complications and mortality; it should be intravenously administered if indicated, but it should not be used in all patients.Öğe A Demonstrative Carbon Monoxide Intoxication(Derman Medical Publ, 2014) Sahan, Mustafa; Yasaran, Iffet; Karakus, Ali[Abstract Not Available]Öğe Dystonia due to Bee Sting: A Case Report(Aves, 2014) Karakus, Ali; Caliskan, Koca; Duru, Mehmet; Kuvandik, Guven; Arslan, Gokhan; Erdogan, Yakup Kadri; Sahan, MustafaIntroduction: Dystonia is anabnormal contraction due to primary and secondary causes of the muscles in the body. Case Report: In the literature, although many cases of congenital or edynsel with dystonia have been reported, a case as a result of a bee sting has not. Conclusion: We aimed to present a case with recurrent dystonia as a result of a bee sting.Öğe Effects of intralipid and caffeic acid phenyl esther (CAPE) against hepatotoxicity and nephrotoxicity caused by glyphosate isopropylamine (GI)(Sage Publications Inc, 2016) Alp, Harun; Pinar, Neslihan; Dokuyucu, Recep; Kaplan, Ibrahim; Sahan, Mustafa; Senol, Serkan; Karakus, AliThis study was aimed to investigate the protective effects of caffeic acid phenyl esther (CAPE) and Intralipid (IL) against hepatotoxicity and nephrotoxicity caused by acute intoxication of glyphosate (N-phosphonomethyl) glycine) (GI) in rats. Forty-nine Wistar Albino rats were randomly divided into seven groups as: I, Control; II, Intralipid (IL) (18.6 mL/kg, orally); III, CAPE (10 mu mol/kg, intraperitoneally); IV, GI (4 mg/kg/day, intraperitoneally); V, GI + IL; VI, GI+CAPE; and VII, GI + IL + CAPE. Total antioxidant status (TAS) and total oxidant status (TOS) levels were measured in serum samples. Tissues were analyzed with hematoxylin and eosin (H&E) staining protocol. Bcl-2, Bax, and caspase-3 were evaluated by immunohistochemical method. The results revealed that, in hepatic tissues, the TAS levels were lower and the TOS levels were higher in the GI group compared to other groups. In renal tissues, the TAS levels were significantly lower in the GI group than in the control, IL, CAPE, and GI + IL + CAPE groups. The TOS levels were significantly higher in the GI group than in the control group. Moreover, histopathological analysis revealed severe hepatotoxicity in the GI group. In the GI + CAPE + IL group, hepatotoxicity recovered significantly. Nephrotoxicity was also observed in the GI group and moderately reduced in the GI + CAPE group. Biochemical results were confirmed by histopathologic examination. The results also revealed that CAPE and IL, due to their antioxidant effects, have a decreasing effect against both hepatotoxicity and nephrotoxicity caused by GI. Therefore, CAPE and IL may function as potential agents for supportive therapy since they decrease organ damage, or may facilitate the therapeutic effects of the routine treatment of patients with GI poisoning.Öğe Evaluation of patients with snakebite who presented to the emergency department: 132 cases(Turkish Assoc Trauma Emergency Surgery, 2016) Sahan, Mustafa; Tasin, Veyis; Karakus, Ali; Ozcan, Oguzhan; Eryigit, Umut; Kuvandik, GuvenBACKGROUND: The present objective was to evaluate clinical stages, complications, treatment modalities, and termination of treatment in patients who presented to the emergency department with snakebite. METHODS: A total of 132 snakebite cases were retrospectively examined using emergency department records. RESULTS: The majority of patients, 42.9% (n=57), had grade 0 snakebite. The local complication most frequently observed was pain (42.4%, n=56); the most common systemic complication was prolonged international normalized ratio (INR) level (5.3%, n=7). Local complications were observed in patients at all stages, while systemic complications were observed only in patients at advanced stages. Antivenom was administered in 46.4% (n=61) of patients, 52.2% (n=69) of patients were hospitalized, and 47.7% (n=63) of patients were discharged after 6-12 hours of monitoring. No negative outcome was observed during 6-month or year-long follow-up. CONCLUSION: Complications should be evaluated based on type of toxin, and appropriate treatment should be initiated efficiently, according to clinical stage. This approach reduces or prevents the development of complications.Öğe Evaluation of the relationship between thromboembolic risk score (CHA2DS2-VASc) and inflammation and coagulation markers in patients with non-valvular atrial fibrillation in emergency department(Scientific Publishers of India, 2016) Yaman, Fatih Nazmi; Civelek, Birol; Yavuz, Bunyamin; Yilmaz, Mustafa; Atescelik, Metin; Sahan, Mustafa; Goktekin, Mehmet CagriObjective: To evaluate the relationship between CHA2DS2-VASc score and inflammation and coagulation markers in patients admitted to Emergency Department (ED) with non-valvular Atrial Fibrillation (AF). Methods and Results: Eighty-four patients with non-valvular AF were included in the study. CHA2DS2- VASc scores were calculated for these patients. In addition, plasma levels of BNP, hs-CRP, CRP, vWF and D-dimer were measured. The relationship between CHA2DS2-VASc score and these parameters were evaluated. Eleven (13%) patients were considered to be at low-risk due to CHA2DS2-VASc score being<2 and 73 (87%) patients were considered to be at high risk due to CHA2DS2-VASc score being ? 2. The mean age of patients was 68 ± 13 years and 50 (60%) of patients were male. Plasma BNP, hs-CRP, CRP, vWF and D-dimer levels were significantly higher in high-risk group. In addition, a significant positive correlation was found between CHA2DS2-VASc score and BNP (r=0.436, p<0.001), D-Dimer (r=0.356, p=0.003), hs-CRP (r=0.335, p=0.002), CRP (r=0,331, p=0.002), vWF (r=0.330, p=0.002) and patient age (r=0.573, p<0.001). Conclusion: It was found that BNP, hs-CRP, CRP, vWF and D-dimer levels increase significantly and that there is a positive correlation between CHA2DS2-VASc and these markers in high-risk patients with CHA2DS2-VASc score ? 2. © 2016, Scientific Publishers of India. All rights reserved.Öğe Evaluation of the relationship between thromboembolic risk score (CHA2DS2-VASc) and inflammation and coagulation markers in patients with non-valvular atrial fibrillation in emergency department.(Allied Acad, 2016) Yaman, Fatih Nazmi; Civelek, Birol; Yavuz, Bunyamin; Yilmaz, Mustafa; Atescelik, Metin; Sahan, Mustafa; Goktekin, Mehmet CagriObjective: To evaluate the relationship between CHA(2)DS(2)-VASc score and inflammation and coagulation markers in patients admitted to Emergency Department (ED) with non-valvular Atrial Fibrillation (AF). Methods and Results: Eighty-four patients with non-valvular AF were included in the study. CHA(2)DS(2)-VASc scores were calculated for these patients. In addition, plasma levels of BNP, hs-CRP, CRP, vWF and D-dimer were measured. The relationship between CHA(2)DS(2)-VASc score and these parameters were evaluated. Eleven (13%) patients were considered to be at low-risk due to CHA(2)DS(2)-VASc score being<2 and 73 (87%) patients were considered to be at high risk due to CHA(2)DS(2)-VASc score being >= 2. The mean age of patients was 68 +/- 13 years and 50 (60%) of patients were male. Plasma BNP, hs-CRP, CRP, vWF and D-dimer levels were significantly higher in high-risk group. In addition, a significant positive correlation was found between CHA(2)DS(2)-VASc score and BNP (r=0.436, p<0.001), D-Dimer (r=0.356, p=0.003), hs-CRP (r=0.335, p=0.002), CRP (r=0,331, p=0.002), vWF (r=0.330, p=0.002) and patient age (r=0.573, p<0.001). Conclusion: It was found that BNP, hs-CRP, CRP, vWF and D-dimer levels increase significantly and that there is a positive correlation between CHA(2)DS(2)-VASc and these markers in high-risk patients with CHA(2)DS(2)-VASc score >= 2.Öğe One-Sided Weakness Admitted with Hypokalemic Periodic Paralysis(Derman Medical Publ, 2014) Yaman, Fatih Nazmi; Sahan, Mustafa; Yilmaz, MustafaHypokalemic periodic paralysis (HPP) is a genetic disorder that characterized by recurrent attacks of skeletal muscle weakness with associated hypokalemia which is precipitated by hypotermia, stress, infection, carbonhydrate load, glucose infusion, metabolic alkalosis, general anesthesia, steroids and licorice root. 52-year-old male patient while working in a cold enviroment, began to complain of weakness in the arms and legs. The patient was brought to the emergency department due to the continuation of weakness complaints in the left arm and leg. The neurological examination had 5/5 strength in the upper-right and lowerright extremities, 3/5 strength in the upper-left and lower-left extremities. Serum electrolytes: Potassium: 2.7 mEq/L, 1.9 mEq/L control. There was no evidence of bleeding and infarction in Computerized Brain Tomography and Brain MR. After intravenous infusion of potassium, at the third hour the patient's neurological symptoms resolved completely, patient was mobilized. In this case we present one-sided weakness admitted to the emergency department, the diagnosis of patient with HPP. We aimed to emphasize that this diagnosis should be keeping in mind that among the causes paralysis and delayed diagnose and treatment may be mortal in HPP.Öğe Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester (CAPE) on Hepatotoxicity and Pancreatic Injury Caused by Dichlorvos in Rats(Springer/Plenum Publishers, 2016) Alp, Harun; Pinar, Neslihan; Dokuyucu, Recep; Sahan, Mustafa; Oruc, Cem; Kaplan, Ibrahim; Senol, SerkanThe present study was aimed to the investigate the protective effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity and pancreatic injury caused by acute dichlorvos (D) intoxication in rats. Forty-eight Wistar rats were randomly divided into seven groups each containing seven rats except control groups. The groups included control, D, CAPE, IL, D + CAPE, D + IL, and D + CAPE + IL. Total antioxidant status and total oxidative stress levels were measured by automated colorimetric assay. Tissues were evaluated using hematoxylin and eosin (H&E) staining. Tissues were analyzed with hematoxylin and eosin by using standard protocols. Also, Bcl-2, Bax and caspase-3 were evaluated by immunohistochemical method in liver tissue. Total oxidant status in control, CAPE, and IL groups were significantly lower, and total antioxidant status in the D + CAPE, D + IL, and D + IL + CAPE groups were significantly higher compared to the D group. CAPE and IL treatment decreased the apoptotic and mitotic cell count in liver tissue. Parenchymal necrosis caused by dichlorvos is observed in pancreas tissues of rats. Mild congestion and edema formation occurred in pancreas tissues following D + CAPE and D + IL therapies. These results indicate that CAPE and IL have the potential to decrease oxidative stress and hepatic and pancreatic injuries caused by acute dichlorvos intoxication. These drugs can be considered as a new method for supportive and protective therapy against pesticide intoxication.Öğe Role of Inflammatory Mediators in the Prediction Angiographic Thrombus in Patients with Acute Coronary Syndrome(Derman Medical Publ, 2015) Tasin, Veyis; Kuvandik, Guven; Karakus, Ali; Sahan, Mustafa; Duru, Mehmet; Kurt, Mustafa; Ozer, CahitAim: Inflammatory mechanisms had played a major role in the formation and prognosis of acute myocardial infarction. Inflammatory mediators was assciated with negative consequences of acute myocardial infarction. This study tested the hypothesis that in the acute phase of acute coronary syndrome, leukocyte count, neutrophil count, neutrophil lymphocyte ratio, and high sensitivity C reactive protein (hsCRP) are predictive of angiographic thrombus formation in the infarct related artery. Material and Method: This prospective study included 150 consecutive patients with acute coronary syndrome. Patients were assigned to a thrombus formation group (n=65) and a non thrombus formation group (n=85). Blood samples for measurement of hsCRP and for routine blood laboratory studies were collected before to coronary angiography. Numerical data were expressed as mean +/- Standard deviation. Nominal data were expressed as the number and percentage. Comparisons between groups, chi-square test was used for nominal variables. Comparisons between groups, t-test was used for numerical data. All statistical analyzes, p < 0.05 was considered significant. Results: The levels of hsCRP, total leukocyte counts, neutrophil counts, and neutrophil/lymphocyte ratios were substantially higher in the thrombus formation group than in the non thrombus formation group patients (for each, P < 0.05). T-test analyses identified hsCRP, leukocyte count, neutrophil count, and neutrophil/lymphocyte ratio as independent predictors of thrombus formation in the infarct-related artery (for each, P < 0.05). Discussion: In patients with acute coronary syndrome, higher leukocyte conut, neutrophil count, neutrophil / lymphocyte ratio and level of hsCRP are predictors to indicate thrombus formation.Öğe A Sample of Crisis Management in the Emergency Department and Evaluation of Patients; Reyhanli-Hatay-Turkey Experience(Derman Medical Publ, 2014) Karakus, Ali; Sahan, Mustafa; Duru, Mehmet; Kuvandik, Guven; Caliskan, Koca; Arslan, Gokhan; Tasin, VeyisAim: Natural disasters, terrorist bombings, transportation and industrial accidents can lead to many deaths and injuries. The number of deaths and injuries in these situations are closely related to cooperation among police, fire fighters, ambulances and hospital staff. Practice and organized positioning can improve such cooperation and experiences. In this study, we aimed to investigate the medical situation of the patients admitted to our hospital emergency service after the terrorist bombing attack occurred on Saturday May 11th, 2013 at about 14: 00 pm in the Reyhanli province and to evaluate our hospital applications. Material and Method: Data including gender, age, Glascow Coma Scale score, Injury Severity Score-ISS, K-Revise Trauma Score(RTS), type of transportation and injury, duration of treatment and prognosis of the patients injured after the explosion were collected retrospectively from the hospital records. Results: The terrorist bombing attack was the bloodiest event in the history of the Republic of Turkey. After the explosion, 51 people died. 27 of the 146 injured patients were admitted to our hospital. 20 of them were male and 7 were female. The mean age of the patients was 31,85 (1-63). Glascow Coma Scale scores were 3-8 for 3 patients, 9-13 for 6 patients and 14-15 for 18 patients. The most frequent injuries were observed in the extremities and soft tissues. 15 patients were discharged after their treatment and 9 patients were hospitalized by different services related to their medical conditions. Three patients died in the emergency department. The size of the event and the number of injured patients were evaluated by the doctors in charge in emergency service and the 112 paramedics. Then, other relevant doctors, administrative officers and health care staffs were instructed and called to the hospital. Appropriately triaged, monitored and treated patients were resulted after evaluating their conditions. Discussion: The soft tissue injuries were the most common case group in relation to the size of the event. The relationship was determined between trauma score values and mortality. Therefore, emergency services should be prepared to the cumulative injuries such as bombing events.Öğe Spontaneous hemopneumothorax case that presented to the Emergency Department in shock state(Elsevier Science Bv, 2010) Karakus, Ali; Kandis, Hayati; Gungor, Ahmet; Sahan, Mustafa; Sonmez, ErtanSpontaneous hemopneumothorax is a rare medical entity in which bleeding into the pleural space causes life-threatening condition in patients. Even though spontaneous pneumothorax cases are more commonly referenced in the literature, spontaneous hemopneumothorax is rarely encountered in clinical practice. We aimed to report a patient who presented to the emergency department in the state of shock and was diagnosed as a spontaneous hemopneumothorax.Öğe Systemic side effects of locally used oxymetazoline(E-Century Publishing Corp, 2015) Dokuyucu, Recep; Gokce, Hasan; Sahan, Mustafa; Sefil, Fatih; Tas, Zeynel Abidin; Tutuk, Okan; Ozturk, AtakanObjectives: The object of the study is to experimentally investigate the possible systemic side effects of Oxymetazoline including its nasal spray which has been in use for a long time both by the physicians and patients. There is no study in the literature to address the damages of oxymetazoline on the end organ. Materials and methods: The study conducted on 2 groups of rat. Group 1 (n = 8): Control; and Group 2 (n = 8): Oxymetazoline. During 4 week, the control group was applied with 2 drops of saline water on each nasal cavity 3 times a day and the other group was applied with 2 drops of oxymetazoline HCl 3 times a day. At the end of experiment, samples from mandible, parotid and tails of the rats were taken in 10% formalin for histopathological investigations. Results: In histopathological experiments, when compared with the control group, the oxymetazoline group showed significant increase in many of the histopathological parameters (ischemic changes: P = 0.0001; congestion: P = 0.0006; arterial thrombosis: P = Ns; PNL accumulations: P = 0.001; necrosis: P = 0.0001; and ulceration: P = 0.014). The results of histopathologic tests on the samples taken from mandible and parotid gland, in comparison with the control group, showed no significant increase (focal inflammation: P = Ns; and lymphocyte aggregation: P = Ns). Conclusion: Due to the damage that the long-term use of nasal spray including oxymetazoline, it may cause injury on the end organ, which we revealed in our histopathological experiments. We believe that it's essential for the physicians to provide information on the side effects of the medicine to their patients who use for a long term.Öğe Venous involvement in sickle cell diseases(E-Century Publishing Corp, 2016) Helvaci, Mehmet Rami; Gokce, Cumali; Sahan, Mustafa; Hakimoglu, Sedat; Coskun, Mesut; Gozukara, Kerem HanBackground: Sickle cell diseases (SCDs) cause an accelerated atherosclerotic process in whole body. We tried to understand whether or not there is an additional venous involvement in the SCDs. Methods: As one of the significant endpoints of the SCDs, cases with chronic obstructive pulmonary disease (COPD) and without were collected into the two groups. Results: The study included 427 patients (220 males). There were 71 patients (16.6%) with COPD. Mean age of patients was significantly higher in the COPD group (32.8 versus 29.8 years, P=0.005). The male ratio was significantly higher in the COPD group, too (78.8% versus 46.0%, P<0.001). Smoking (35.2% versus 11.2%, P<0.001) and alcohol (7.0% versus 1.9%, P<0.01) were also higher among the COPD cases. Beside these, priapism (14.0% versus 2.8%, P<0.001), cirrhosis (8.4% versus 3.3%, P<0.05), leg ulcers (23.9% versus 12.0%, P<0.01), digital clubbing (25.3% versus 6.7%, P<0.001), coronary heart disease (23.9% versus 13.7%, P<0.05), chronic renal disease (15.4% versus 7.0%, P<0.01), and stroke (16.9% versus 8.1%, P<0.01) were all higher among the COPD cases. Although deep venous thrombosis and/or varices and/or telangiectasias of the lower limbs were also higher among them, the difference was nonsignificant (11.2% versus 5.0%, P>0.05) probably due to small sample size of the COPD group. Conclusion: SCDs are chronic catastrophic processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Beside the accelerated atherosclerotic process, venous involvement may also be common in the SCDs.
