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Öğe Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress(Wiley, 2007) Serarslan, G.; Altug, E.; Kontas, T.; Atik, E.; Avci, G.Background Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury. Aim To determine the effects of caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory agent, on wound healing in rats. Methods In total, 40 male rats were divided into two groups: one group treated with CAPE (n = 20) and a second untreated control group (n = 20). A linear full-thickness incision was performed on the back of each rat and sutured. After incision, CAPE was given to the treatment group and saline to the control group. On days 1, 3, 7 and 14, five animals in each group were killed, and wound tissues dissected for biochemical and histopathological analysis. Results Wound tissues showed a significant increase in glutathione and nitric oxide levels, and a significant decrease in malondialdehyde levels and superoxide dismutase levels in the CAPE group compared with the control group. Histopathology of the wound tissues displayed rapid epithelium development in the CAPE group compared with the control group. Conclusions This study has demonstrated that CAPE partly accelerates full-thickness wound healing by its antioxidant and ROS-scavenging capabilities.Öğe Erythematous plaques on the auditory canal(Elsevier Masson, 2017) Serarslan, G.; Arli, C.; Atik, E.[Abstract Not Available]Öğe Giant congenital cellular blue naevus of the scalp with disseminated common blue naevi of the body(Wiley, 2009) Serarslan, G.; Yaldiz, M.; Verdi, M.[Abstract Not Available]Öğe Hearing loss in patients with Behcet's disease: an audiological and transient evoked otoacoustic emission study(Cambridge Univ Press, 2010) Aslan, S.; Serarslan, G.; Savas, N.; Teksoz, E.; Dagli, S.Objective: To investigate hearing loss in patients with Behcet's disease. Materials and methods: Twenty-four consecutive cases ofBehqet's disease and 24 sex- and age-inatched controls were included in this study. Pure tone and high frequency audiometric tests were performed and pure tone average hearing thresholds calculated for both groups. Transient evoked otoacoustic emission testing was also performed. Results: Pure tone audiometry showed a sensorineural hearing loss in 15 of the Behcet's disease cars. Hearing thresholds were significantly higher in the study group than in the control group, on both pure tone frequency (except 0.5 kHz) and high frequency audiometry. Significant reductions in transient evoked otoacoustic emission amplitude were found at 1.4 and 2 kHz in the Behcet's disease patients. There were no significant differences in reproducibility, stimulus intensity or stability, comparing the Behcet's disease patients and controls. Conclusion: Significantly lower mid-frequency amplitudes were found in Behcet's patients on transient evoked otoacoustic emission testing.Öğe Increased macrophage migration inhibitory factor in Behcet's disease and relation with the disease activity(Wiley, 2009) Serarslan, G.; Sogut, S.; Yonden, Z.; Oksuz, H.; Savas, N.; Yenin, J. Z.; Arpaci, A.[Abstract Not Available]Öğe Investigation of oxidative stress in patients with alopecia areata and its relationship with disease severity, duration, recurrence and pattern(Wiley, 2015) Yenin, J. Z.; Serarslan, G.; Yoenden, Z.; Ulutas, K. T.Background Alopecia areata (AA) is an inflammatory autoimmune disease that causes hair loss on the scalp or trunk without scarring. Although the precise aetiopathogenesis of alopecia areata remains unknown, oxidative stress is thought to play a role. Aim To investigate the relationship between severity and the role of oxidative stress in AA, by measuring plasma oxidant levels and antioxidant enzyme activities in erythrocytes. Methods In total, 62 patients with AA (24 males and 38 females), and 62 sex- and age-matched healthy controls (HCs) were enrolled in the study. We investigated the levels of plasma malondialdehyde (MDA) and the activities of erythrocyte catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). The relationship between oxidative stress and AA was also investigated with regard to disease pattern, severity, duration and recurrence. Results The mean erythrocyte GSH-Px and SOD activities were significantly reduced (P<0.001 and P<0.001 respectively) compared with the control group. Plasma MDA levels were increased but statistically insignificant (P=0.08) in patients with AA compared with controls. No significant difference between erythrocyte CAT activities was observed between patients and controls (P=0.2). In addition, we observed no statistically significant difference in patient plasma MDA levels or erythrocyte CAT, GSH-Px or SOD activities with regard to AA severity, duration, recurrence or pattern (P>0.05). Conclusions Patients with AA displayed reduced erythrocyte SOD and GSH-Px activities and enhanced plasma MDA levels. These findings support the possible role of oxidative stress in the pathogenesis of AA.Öğe Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study(Wiley-Blackwell, 2012) Serarslan, G.; Savas, N.; Yenin, J. Z.Objective We aimed to determine whether there was a difference between adult and paediatric alopecia areata patients with respect to the severity and pattern of the disease, nail changes and personal and family history of autoimmune diseases and also in comparison with controls. Methods Two groups were included: patients with onset of alopecia before the age of =18 years and >18 years. The total number of the patients were 124. The control group was comprised of 114 age- and gender-matched patients. Results There were 81 adults and 43 children. No statistically significant difference was present between disease severity and gender, age, personal and family history of autoimmune disease in the adult and paediatric group (P > 0.5). Thirteen adults with scalp involvement had nail changes. 61.5% had mild and 38.46% had severe disease (P > 0.5). Of the 43 paediatric patients, 10 patients had nail changes. Severe alopecia was present in 40% of patients with nail changes; however, 9.1% had severe alopecia in patients without nail changes (P = 0.04). There was no statistical significance in patients with and without familial autoimmune diseases when compared with pattern and severity of the diseases between the two groups. Conclusion The frequencies of autoimmune and atopic diseases were not different between adult and paediatric patients and the control group. We did not find a statistically significance between disease severity and personal and family history of autoimmune disease in the two groups. Disease severity was not related to nail changes in the adult group. However, severe alopecia areata was more prevalent in children with nail changes. Furthermore, ophiasis pattern was more prevalent in the paediatric group with nail changes compared with the adult group.Öğe The Laugier-Hunziker syndrome(East African Medical Association, 2004) Akcali, C.; Serarslan, G.; Atik, E.Laugier-Hunziker syndrome is a rare, acquired, benign hyperpigmentation of the lips, oral mucosa and nails. Although it is a benign disorder, other pigmentary disorders affecting the oral mucosa and nails must be considered in the different diagnosis. We presented a case of Laugier-Hunziker syndrome, showed clinical and histopathologic features of the disease.Öğe Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of disease(Wiley, 2010) Serarslan, G.; Yonden, Z.; Sogut, S.; Savas, N.; Celik, E.; Arpaci, A.Background. Vitiligo is a disorder of pigmentation characterized by the presence of depigmented skin macules. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity. Aims. To determine serum level of MIF in patients with vitiligo and compare with healthy controls. We also aimed to determine whether there is a relationship between MIF levels and the disease duration, clinical vitiligo and involved body surface area (BSA) in patients with vitiligo. Methods. The study group comprised 30 patients with vitiligo (14 men, 16 women) and 30 healthy controls, matched for age and gender. Blood samples were taken for MIF analysis. Results. The mean serum level of MIF in patients with vitiligo (40.83 +/- 31.66 pg/mL) was significantly higher than that of the control group (21.00 +/- 6.48 pg/mL) (P = 0.002). There was a positive correlation between disease duration and MIF levels (r = 0.601, P < 0.001). Mean MIF level of patients with acral and acrofacial vitiligo (n = 6) was 48.25 +/- 32.02 pg/mL, and of patients generalized vitiligo (n = 18) was 44.46 +/- 35.25 pg/mL. There was no significant difference between these two groups (P > 0.05). However there was a significant difference in MIF levels between patients with localized (20.41 +/- 5.23, n = 5) and acral-acrofacial (P = 0.02) vitiligo and those with generalized (P = 0.006) vitiligo. There was no relationship between BSA and MIF levels. Conclusions. Mean serum MIF level of patients with vitiligo was higher than that of controls, indicating that MIF has a role in the pathogenesis of vitiligo.Öğe Partial unilateral lentiginosis with ipsilateral ocular nevus(Blackwell Publishing, 2007) Serarslan, G.[Abstract Not Available]Öğe The prevalence of interdigital erythrasma in southern region of Turkey(Wiley-Blackwell, 2012) Inci, M.; Serarslan, G.; Ozer, B.; Inan, M. U.; Evirgen, O.; Alagoz, G. Erkaslan; Duran, N.Background Erythrasma is a skin infection which is caused by Corynebacterium minutissimum. Interdigital erythrasma is the most common form. Objective The aim of this study was to detect the frequency and risk factors of interdigital erythrasma in patients with clinically suspected tinea pedis. Methods This study was conducted between June and December 2010 and included 122 patients who had interdigital foot lesions. All patients were examined using a Woods lamp. The smears were stained using Grams method. Direct examination was performed using 20% potassium hydroxide. Sabouraud dextrose agar and brain heart infusion agar were used for cultures. Moreover, the demographical characteristics of patients, concomitant diseases and clinical findings were also recorded. Cases that were found to be positive on Woods lamp examination and/or Gram staining/culture were considered as erythrasma. Results The rate of erythrasma was found to be 46.7%. The mean age was 43.6 years, and the disease was more prevalent in men. The most common clinical finding was desquamation. Mycological examination was found as positive in 40.35% of the patients. No growth was observed in bacteriological cultures. It was found that using only Woods lamp examination or Gram staining resulted in 11 (9%) and 19 positive patients (15.6%), respectively, whereas using both Woods lamp examination and Gram staining concurrently resulted in 27 positive patients (22.1%). Conclusion Interdigital erythrasma is a commonly seen condition and can clinically mimic tinea pedis. A Woods lamp is a good diagnostic tool, but Gram staining, particularly in those with a negative Woods lamp result, may be a useful method.Öğe Widespread maculopapular rash due to intramuscular interferon beta-1a during the treatment of multiple sclerosis(Sage Publications Ltd, 2008) Serarslan, G.; Okuyucu, Ee; Melek, Im; Hakverdi, S.; Duman, T.We describe a 41- year- old woman with multiple sclerosis, who presented erythematous maculopapular rash on the trunk and extremities after the second injection of interferon beta- 1a. Histopathologic examination of the lesion revealed lymphocytic exocytosis and perivascular lymphocytic infiltrate in the dermis. Oral antihistamine and topical corticosteroid was started. After improvement of the lesions, the third injection was performed. However, the same reaction occurred. A prick test, which was performed 6 weeks after the eruption, also revealed positive reaction. Although injection- site reactions have been observed with interferon beta- 1a, to our knowledge there have been no previous reports of interferon beta- 1a- induced widespread cutaneous reaction.
