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Öğe ASSOCIATION OF FETUIN-A WITH GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND OXIDATIVE STRESS IN SICKLE CELL ANEMIA(Carbone Editore, 2016) Ulutas, Kemal Turker; Buyukbas, Sadik; Yilmaz, Nigar; Arpaci, Abdullah; Kaya, HasanAim: Oxidative stress has crucial effects over vascular pathophysiology of Sickle Cell Anemia (SCA), and contributes atherosclerosis at advanced stages of the disease. In contrast to be acknowledged the possible role of Fetuin-A in the development of atherosclerosis, its association with vascular changes in SCA appears to warrant further investigation. In the study, we aimed to illuminate vascular pathophysiology of SCA via investigating Fetuin-A levels and its relationship with oxidative stress parameters. Material and methods: Fourty SCA patients and and 35 healthy individuals (n: 35) were included in the study all. After analyzing hematological data, Malondialdehyde (MDA), Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD) and Catalase (CAT) were measured throughout preparing hemolysate from samples with EDTA. Fetuin-A was analyzed from serum samples. Results: Fetuin-A (p<0.001) and MDA levels (p<0.001) were measured significantly higher in SCA group. Similarly, G6PD (p<0.001) and SOD (p<0.01) enzyme activities were determined higher in SCA when compared to the control group. A novel positive correlation was found among Fetuin-A, G6PD (r=0.435, p<0.0001) and MDA (r=0.547, p<0.0001). However, there was no statistical significance between the groups for CAT and GSH-Px. ROC analyze suggested 0,97 ng/mL as the cutoff value for Fetuin-A (Area Under the Curve: 0.713, sensitivity: 62%, specificity: 80%, p:0,002) and 0,06 mu mol/gr Hb as the cutoff value for MDA (Area Under the Curve: 0.898, sensitivity: 87 %, specificity: 80%, p:<0,001). Conclusion: Elevated Fetuin-A in patients with SCA and its positive correlations with both MDA and G6PD suggested that Fetuin-A might have an important role for pathophysiology of SCA. Additionally, Fetuin-A may be useful for evaluating severity of disease with high specificity cutoff value as MDA.Öğe Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report(Cukurova Univ, Fac Medicine, 2016) Kilinc, Cetin; Ulutas, Kemal Turker; Akcimen, Beril; Celik, Levent; Duran, NizamiPseudomonas aeruginosa strains may develop the resistance to antibiotics via different mechanisms such as, alteration of protein binders of penicillin, porin mutations, DNA-gyrase mutation and active expulsion pumps. Especially, multi-drug resistant P. aeruginosa strains, are known to be most important cause of mortality in the intensive care units. Special antibiotic therapy is required, because of having the multiple antibiotic resistances. The case reports a 67-year-old male patient who had a history of 6 years paraplegia. He admitted to the emergency department with impaired general condition, including a week ongoing nausea, chest pain, cough, phlegm, wheezing and fatigue. Widespread crepitant rales were detected up to the middle and lower zones of both lungs. Besides, there was CRP elevation, hyperuricemia, a consolidated infiltration compatible with increased opacity at lower zone of right lung and reticulonodular style increased opacity at upper zone of right lung on chest. On disk diffusion, there was resistance to all antibiotics except colistin. Although colistin treatment was initiated, the patient was lost due to cardiac arrest at the 3rd day of treatment. This case is reported to be observed for the first time of P. aeruginosa infection that was extensively drug-resistant to antibiotics except colistin in our hospital, and to highlight importance of true treatment arrangements according to antibiotic susceptibility.Öğe Comparison of Platelet Distribution Width and CA19-9 in Resectable Pancreas Cancer(2018) Ulutas, Kemal Turker; Sarici, Inanc Samil; Arpaci, AbdullahBackground: Platelets are considered an important source of prothrombotic agents associated with inflammation in cancer related diseases. We aimed to compare the diagnostic accuracy of the platelet distribution width (PDW) and CA19-9 in resectable pancreas cancer. Method: A total of 83 stage-1 and 2 pancreatic adenocarcinoma (PAC) patients, and 85 age and sex-matched healthy participants were included in the study. All preoperative patient data, including PDW and CA19-9 were analyzed in terms of sensitivity, specificity, positive and negative predictive values, likelihood ratios, and diagnostic accuracy. Results: Demographic features were not significantly different among the groups. Platelet distribution width and CA19-9 were significantly higher in PAC compared to control group (p= 0.0001). Diagnostically, the sensitivity and specificity were 79% and 85% for PDW, while 78% and 91% for CA19-9. Diagnostic accuracy was measured by the area under the ROC curve, and PDW differs significantly (p<0.001), with a value of 0.874 (95% CI: 0.804-0.929). Conclusion: Platelet distribution width indicated similar sensitivity and specificity with CA19-9 in patients with resectable PAC. This result strongly advice that PDW, which has more routine option and cost-effectivity than CA19-9, can be used for diagnosis of resectable PAC as a strong alternative.Öğe Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats(Sage Publications Inc, 2013) Basarslan, Fatmagul; Yilmaz, Nigar; Davarci, Isil; Akin, Mustafa; Ozgur, Mustafa; Yilmaz, Cahide; Ulutas, Kemal TurkerOxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.Öğe Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis?(E-Century Publishing Corp, 2014) Ulutas, Kemal Turker; Dokuyucu, Recep; Sefil, Fatih; Yengil, Erhan; Sumbul, Ahmet Taner; Rizaoglu, Hatice; Ustun, IhsanObjective: Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA(1c)) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA(1c) and duration of diabetes in the diabetic patients, respectively. Materials and Methods: The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabetic patients, all diabetic patients were divided into two groups according to their HbA(1c) levels: group A consisted of patients with HbA(1c) levels <= 7% and group B consisted of patients with HbA(1c) levels >7%. Results: MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA(1c) and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM. Conclusion: Our findings suggested an association between MPV and HbA(1c). Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.Öğe Increased Mean Platelet Volume in Patients with Depression(Derman Medical Publ, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal Turker; Kivrak, YukselAim: It is well known that the mean platelet volume (MPV) is a good indicator of platelet activity and the incidence of cardiovascular diseases. Major depressive disorder may emerge in association with the cardiovascular diseases. In this study, we aimed to investigate the relationship between MPV and major depressive disorder. Material and Method: MPV values of 65 patients with major depression were compared with 66 age-and sex-matched healthy subjects. Body mass index (BMI), MPV, platelet count (PLC) of all participants were measured. Beck Depression Scale (BDS) was performed to measure severity of depression. Results: MPV values of patients who had major depression were found to be significantly higher than the control group. Comparing Major Depression with the control group, there was no significant difference in terms of platelet count. In the depression group, there was no correlation between the severity of depression and MPV. Discussion: As a result, the mean platelet volume was determined to have a significant increase in major depressive disorder compared with healthy individuals. This also may be informative about the association between pathologies related vascular structure such as vascular atherosclerosis and depression.Öğe Increased mean platelet volume in patients with panic disorder(Dove Medical Press Ltd, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Kivrak, Yuksel; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal TurkerObjective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age-and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.Öğe Investigation of antioxidant enzyme polymorphism in chronic obstructive pulmonary disease patients(Scientific Publishers of India, 2018) Arpaci, Abdullah; Yalin, Serap; Taskin, Devrim; Fakioglu, Fusun; Ulutas, Kemal Turker; Comelekoglu, UlkuBackground: Antioxidant system enzyme activity and polymorphism were investigated in Chronic Obstructive Pulmonary Disease (COPD), which is increasingly prevalent both in the world and our country. Methods: Malondialdehyde (MDA) was measured to determine lipid peroxidation, while Catalase (CAT), Paraoxonase (PON) and Superoxide Dismutase (SOD) enzyme activities were measured to determine antioxidant activity. For molecular analysis, leukocytes were separated and DNA was isolated from cell nuclei and the targeted genes were amplified by using PCR. Targeted base changes were detected by the restriction fragment length polymorphism technique. Results: Evaluating CAT polymorphism, there was 35 (35%) TT, 52 (52%) TC and 13 (13%) CC genotypes in the control group, as 38 (38%) TT, 40 (40%) TC and 22 (22%) CC genotypes in the patient. In SOD, there were 32 (32%) TT, 49 (49%) TC, 19 (19%) CC genotypes in the control group, as 34 (34%) TT, 50 (50%) TC and 16 (16%) CC genotypes in the patient. In PON55, there were 50 (50%) LL, 38 (38%) LM, 12 (12%) MM genotypes in the control group, as 39 (39%) LL, 49 (49%) LM and 12 (12%) MM genotypes in the patient. In PON192, there were 77 (77%) QQ, 21 (21%) QR, 2 (2%) RR genotypes in the control group, as 66 (66%) QQ, 29 (49%) QR, 5 (5%) RR genotypes in the patient. There was no significant difference in genotype distribution for CAT, SOD, PON55 and PON192 polymorphisms between groups. Conclusion: In conclusion, COPD patients were found to have a deficiency in the antioxidant defense system. This will lead to the development of oxidative stress in patients and the complications of COPD. There was no polymorphic difference between the control group and South African patients living in Adiyaman in COPD whose genetic characteristics were not fully explained. © 2018, Scientific Publishers of India. All rights reserved.Öğe Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus(Sage Publications Ltd, 2014) Sefil, Fatih; Ulutas, Kemal Turker; Dokuyucu, Recep; Sumbul, Ahmet Taner; Yengil, Erhan; Yagiz, Abdullah Erman; Yula, ErkanObjective Leukocytosis is thought to be directly associated with the pathogenesis of atherosclerosis and metabolic syndrome. Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. There is little information, however, concerning a correlation between glycosylated haemoglobin (HbA(1c)) and NLR. The aim of the present study was to investigate the relationship between NLR and blood glucose regulation. Methods This retrospective study was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA(1c) levels: group 1, HbA(1c) levels7%; group 2, HbA(1c) levels>7%. Venous WBC, neutrophil and lymphocyte counts were determined. Results Of 71 patients included, fasting serum glucose, neutrophil and WBC counts were significantly higher in group 2 compared with group 1. NLR had a positive correlation with HbA(1c). Conclusion There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA(1c) in patients with type 2 diabetes mellitus.Öğe Investigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndrome(Springer, 2014) Erden, Ersin Sukru; Genc, Sebahat; Motor, Sedat; Ustun, Ihsan; Ulutas, Kemal Turker; Bilgic, Hatice Kayim; Oktar, SuleymanObstructive sleep apnea syndrome (OSAS) is a common health problem, and associated with obesity, metabolic syndrome (MetS), and diabetes. Growing evidence shows that 25-hydroxyvitamin-D-3 (25-OH-D) insufficiency and high parathyroid hormone (PTH) levels may be correlated to glucose intolerance, MetS, obesity, and cardiovascular abnormalities similar to OSAS. Bisphenol A (BPA) is an endocrine disruptor agent which exerts a wide variety of metabolic effects. It has estrogenic activity and its exposure may contribute to weight gain, obesity, impaired glucose metabolism, and the development of diabetes, also similar to OSAS. The aim of this study is to investigate the relationships between OSAS and serum BPA, 25-OH-D, and PTH levels. This study enrolled 128 subjects, with all of the OSAS patients having been diagnosed by polysomnography. The 128 subjects were divided into three groups: a control (n = 43), a moderate OSAS (n = 23) (AHI = 15-30), and a severe OSAS groups (n = 62) (AHI > 30). The serum BPA, 25-OH-D, and PTH levels for each subject were analyzed. 25-OH-D was lower in both OSAS groups, and PTH was higher in the OSAS groups than in the control subjects. The BPA levels were higher in the severe OSAS group than the moderate OSAS and control. There was a positive correlation between the BPA and body mass index, and a negative correlation between the 25-OH-D and BPA levels in all of the individuals. OSAS is related to high BPA and PTH levels, and low vitamin D levels. There is a positive association between BPA levels and OSAS, and the severity of OSAS. These results suggest that the BPA levels may have a role in the pathogenesis of OSAS.Öğe Protective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brain(Karger, 2013) Aras, Mustafa; Urfali, Boran; Serarslan, Yurdal; Ozgur, Tumay; Ulutas, Kemal Turker; Urfali, Senem; Altas, MuratThe aim of this study was to assess the effects of minocycline on cerebral ischemia-reperfusion (I/R) injury in rats. The study was carried out on 24 male Wistar albino rats, weighing 200-250 g, which were divided into three groups: (i) control (n = 8), (ii) I/R (n = 8) and (iii) I/R + minocycline (n = 8). Minocycline was administrated at a dose of 90 mg/kg p.o. to the I/R group 48, 24 and 1 h before ischemia. Following bilateral exposure of the common carotid arteries by anterior cervical dissection and separation of the vagus nerve, I/R injury was performed by occlusion. Following reperfusion, malondialdehyde (MDA), superoxide dismutase, glutathione peroxidase and catalase levels in the blood and brain tissue, and creatine kinase (CK), CK-BB, lactate dehydrogenase (LDH), neuron-specific enolase (NSE) and protein S100 beta levels in the blood were measured and the histopathological changes were monitored. Regarding histopathological evaluation, symptoms of degeneration were significantly improved in the I/R + minocycline group compared to the I/R-only group. Statistical analysis of the biochemical parameters revealed significant differences in MDA (p < 0.001), nitric oxide (p < 0.05), CK (p < 0.05) and CK-MB (p < 0.05) levels between the I/R + minocycline group and the I/R group. According to the literature, the effect of minocycline is firstly assessed by LDH, CK-MB, NSE and S-100 beta analysis in addition to antioxidant status and histopathological analysis. (C) 2014 S. Karger AG, BaselÖğe Relationship between Serum Resistin and Lipid Levels in Patients with Psoriasis(Cukurova Univ, Fac Medicine, 2015) Yilmaz, Nigar; Ulutas, Kemal Turker; Dogramaci, A. Cigdem; Inan, M. Ugur; Yuksel, Rana; Can, YesimPurpose: Psoriasis is inflammatory skin disease which has increased risk of cardiovascular disease. The etiology is unknown, yet. In cardiovascular disease, resistin which is secreted from adipose tissue, was found correlated with the levels of total cholesterol and LDL. In our study, we aimed to study the relation of serum resistin and lipid levels in patients with psoriasis and correlation of Psoriasis Area and Severity Index (PASI). Material and Methods: In Mustafa Kemal University, Faculty of Medicine, Department of Dermatology, thirty-seven healthy subjects (group I) and thirty-four patients with psoriasis (group II) were enrolled for two groups. The age, gender, blood pressure, body mass index (BMI) and PASI were determined. The level of resistin and lipid profile were studied in serum. Results: The level of resistin in patients with psoriasis (12,3 +/- 3,0 ng/ml) was found increased compared with healthy subjects (6,4 +/- 2,3 ng/ml) (p=0.001). The level of total cholesterol and LDL were increased in patients with psoriasis compared with healthy subjects, respectively (189 +/- 43 mg/dl; 129 +/- 31 mg/dl) (p<0,05; p=0,01). The level of resistin was determined correlated positively with LDL (r=0,306). The level of resistin was found strong correlated positively with PASI (r=0,669). Conclusion: The high risk of cardiovascular disease in patients with psoriasis is known. In our study, the levels of resistin, total cholesterol, LDL which increase in cardiovascular disease, was found increased in patients with psoriasis and correlated with PASI. The level of resistin may be increased with increasing severity of the disease, so that it is thought to be significant determining like the lipid profile in patients with psoriasis.
