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    EFFECT OF GM-CSF LEVELS ON OSTEOPOROSIS IN POSTMENOPAUSAL PERIOD
    (Carbone Editore, 2014) Yagiz, Abdullah Erman; Dokuyucu, Recep; Sumbul, Ahmet Taner; Yengil, Erhan; Ustun, Nilgul; Koca, Irfan; Gogebakan, Bulent
    Objectives: Cytokines and hematopoietic growth factors may play a role in the pathogenesis of osteoporosis. The aim of this study was to assess the relationship between osteoporosis (OP) and granulocyte-macrophage colony stimulating factor (GM-CSF) in postmenopausal period. Materials and methods: Total number of 80 female patients between the ages of 45-75 and who had entered in menopause from at least one year and diagnosed with OP were enrolled in this study. As a control group, 80 healthy volunteer female patients who had entered in menopause from at least one year and had no diagnosis of OP were selected. The age, height, weight, body mass index, duration of menopause, exercise habits of the patients and controls were recorded and bone mineral density was measured for the diagnosis of OP. The serum GM-CSF concentrations of individuals were quantified using a specific enzyme immunoassay kit. Results: There was no significant relationship between the mean age, duration of menopause and body mass index of patients and controls (p>0.05). Serum GM-CSF levels of patients and control groups did not differ significantly (p> 0.05). Conclusion: The results of our study showed that there was no significant correlation between osteoporosis and serum GMCSF levels. Osteoporosis might be correlating with the levels of GM-CSF in bone microenvironment rather than serum levels.
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    Effect of GM-CSF levels on osteoporosis in postmenopausal period
    (Acta Medica Mediterranea, 2014) Yagiz, Abdullah Erman; Dokuyucu, Recep; Sumbul, Ahmet Taner; Yengil, Erhan; Ustun, Nilgul; Koca, Irfan; Gogebakan, Bulent
    Objectives: Cytokines and hematopoietic growth factors may play a role in the pathogenesis of osteoporosis. The aim of this study was to assess the relationship between osteoporosis (OP) and granulocyte-macrophage colony stimulating factor (GM-CSF) in postmenopausal period. Materials and methods: Total number of 80 female patients between the ages of 45-75 and who had entered in menopause from at least one year and diagnosed with OP were enrolled in this study. As a control group, 80 healthy volunteer female patients who had entered in menopause from at least one year and had no diagnosis of OP were selected. The age, height, weight, body mass index, duration of menopause, exercise habits of the patients and controls were recorded and bone mineral density was measured for the diagnosis of OP. The serum GM-CSF concentrations of individuals were quantified using a specific enzyme immunoassay kit. Results: There was no significant relationship between the mean age, duration of menopause and body mass index of patients and controls (p>0.05). Serum GM-CSF levels of patients and control groups did not differ significantly (p> 0.05). Conclusion: The results of our study showed that there was no significant correlation between osteoporosis and serum GMCSF levels. Osteoporosis might be correlating with the levels of GM-CSF in bone microenvironment rather than serum levels.
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    The effect of social support and severity of the disease on posttraumatic growth in ankylosing spondylitis
    (Acta Medica Mediterranea, 2014) Yagiz, Abdullah Erman; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Uruc, Vedat; Paksoy, Hacer; Yengil, Erhan; Ustun, Nilgul
    Aim: Posttraumatic growth (PTG) is described as the positive psychological changes after struggling with highly challenging life circumstances. This study aimed to evaluate PTG in patients with ankylosing spondylitis (AS) who were characterised with posture and joint motion disorders. The clinical and social factors that play a role in the development of PTG were also investigated. Materials and methods: Eighty AS patients aged 18 to 65 years were included in the study. Disease activity was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional status by the Bath Ankylosing Spondylitis Functional Index (BASFI) and spinal mobility by the Bath Ankylosing Spondylitis Metrology Index (BASMI). For the evaluation of the positive psychological changes posttraumatic growth inventory (PTGI) was used, as multidimensional scale of perceived social support (MSPSS) and ways of coping inventory were respectively used to assess social support and coping strategies. Results: The population consists of 58 male and 22 female subjects. The mean total scores of PTG, total social support and coping inventory were 67.90 ± 18.96, 66.42 ± 14.52 and 96.97 ± 10.43, respectively. The total PTG scores were significantly higher in women than in men (p=0.016). BASDAI and BASFI were negatively correlated with PTG, whereas ways of coping and social support were positively correlated with PTG (p=0.001, r=0.352; p=0.044, r=0.226). Conclusion: Social support and ways of coping have a positive effect, whereas disease severity and poor functional index have a negative effection the development of PTG.
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    THE EFFECT OF SOCIAL SUPPORT AND SEVERITY OF THE DISEASE ON POSTTRAUMATIC GROWTH IN ANKYLOSING SPONDYLITIS
    (Carbone Editore, 2014) Yagiz, Abdullah Erman; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Uruc, Vedat; Paksoy, Hacer; Yengil, Erhan; Ustun, Nilgul
    Aim: Posttraumatic growth (PTG) is described as the positive psychological changes after struggling with highly challenging life circumstances. This study aimed to evaluate PTG in patients with ankylosing spondylitis (AS) who were characterised with posture and joint motion disorders. The clinical and social factors that play a role in the development of PTG were also investigated. Materials and methods: Eighty AS patients aged 18 to 65 years were included in the study: Disease activity was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional status by the Bath Ankylosing Spondylitis Functional Index (BASFI) and spinal mobility by the Bath Ankylosing Spondylitis Metrology Index (BASMI). For the evaluation of the positive psychological:changes posttraumatic growth inventory (PTGI),Was used as multidimensional scale of perceived octal support (MSPSS) and ways of coping inventory were respectively used to assess social support and coping strategies. Results: The population consists of 58 male and 22 female subjects. The Mean total scores of PTG, total social support and coping inventory were 67.90 +/- 18.96, 66.42 +/- 14 52 and 96.97 +/- 10.43, respectively. The total PTG scores were significantly higher in Women than in men (p=0.016). BASDAI and BASFI were negatively correlated with PTG, whereas ways of coping and social supF port were positively correlated with PTG (p=0.001, r=0352; p=0.44, r=0226). Conclusion: Social support and ways of coping have a positive effect, whereas disease severity and poor functional index have a negative effection the development of PTG:
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    Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layers Thickness in Ankylosing Spondylitis
    (Informa Healthcare, 2014) Tuzcu, Esra Ayhan; Ustun, Nilgul; Ilhan, Nilufer; Yagiz, Erman; Daglioglu, Mutlu Cihan; Coskun, Mesut; Ilhan, Ozgur
    Objective: To assess the thickness of the retinal nerve fibril layer (RNFL) in cases with ankylosing spondylitis (AS). Materials and methods: The study included 40 AS patients who had no history of acute and/or previous uveitis and 50 healthy controls. After detailed ocular examination, the thickness of the peripapillary RNFL, the macula, and the ganglion cell-inner plexiform layers (GCIPL) were measured by spectral domain optic coherence tomography (SD-OCT). The correlation between the duration of the disease and the thickness of the RNFL, the macula, and the GCIPL were analyzed in the patients who had AS. These patients were then placed into 2 groups according to their BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) score: patients with BASDAI score <4 and those with BASDAI score >= 4. The correlations between the BASDAI score and the mean GCIPL and temporal RNFL thickness were evaluated. Results: No significant difference was detected in the RNFL thickness of the AS patients and that of the controls (p = 0.407). Nor was any significant difference detected in the GCIPL thickness of the AS and the control groups (p = 0.091). In addition, no significant difference was found in the macular thickness when the AS group was compared to the control group (p = 0.139). However, a negative correlation was detected between the duration of the disease and the thickness of the temporal quadrant RNFLs (r = -0.334; p = 0.035). The temporal quadrant RNFL thickness and the mean thickness of the GCPIL were significantly thinner in the AS patients with BASDAI score >= 4 (p = 0.034 and p = 0.025, respectively). Also, the BASDAI score were negatively correlated to the temporal quadrant RNFL and GCIPL thickness (r = -0.332; p = 0.036 and r = -0.348; p = 0.028, respectively). Conclusion: RNFL thickness and GCIPL thickness of ankylosing spondylitis may be affected by the severity and duration of the disease.
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    Recurrent hyponatremia due to tolterodine
    (Canadian Urological Association, 2012) Ustun, Ihsan; Davarci, Mursel; Demirbas, Onur; Ustun, Nilgul; Gokce, Cumali
    [Abstract Not Available]
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    Relation of Fragmented QRS to Tissue Doppler-Derived Parameters in Patients with Familial Mediterranean Fever
    (Elsevier Science Inc, 2013) Celik, Muhammet Murat; Buyukkaya, Eyup; Ustun, Nilgul; Nacar, Alper Bugra; Kurt, Mustafa; Karakas, Mehmet Fatih; Bilen, Perihan
    [Abstract Not Available]
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    Relation of fragmented QRS to tissue Doppler-derived parametersin patients with familial Mediterranean fever
    (Springer Wien, 2015) Celik, Muhammet Murat; Buyukkaya, Eyup; Ustun, Nilgul; Nacar, Alper Bugra; Kurt, Mustafa; Karakas, Mehmet Fatih; Bilen, Perihan
    Familial Mediterranean fever (FMF) may pose a risk for cardiovascular diseases due to continuous inflammatory status observed during the course of the disease. Recently, the presence of fragmented QRS (fQRS) has been recognized as a predictor of myocardial fibrosis. In this study, we aim to investigate the frequency of fQRS and its relation to Doppler-based indices. This study consisted of 80 FMF patients and 30 healthy control subjects. fQRS pattern was defined as the presence of additional R waves or RSR', evidenced by notched R or S wave on electrocardiography (ECG). The patient and the control groups underwent conventional echocardiography and tissue Doppler echocardiography. There was no significant difference between groups regarding age (29 +/- 12 vs 29 +/- 15). FMF patients exhibited a statistically higher frequency of fQRS (% 56 vs % 13) (p < 0.01). E/Em ratio showed a statistically significant increase in the FMF group with fQRS (p < 0.0001), while the mean Em value was markedly lower (p < 0.0001). FMF patients displayed a statistically significant increase in frequency of fQRS. Doppler-derived diastolic index was statistically significantly impaired in FMF patients with fQRS as compared with the patients without fQRS. In conclusion, fQRS might be a new noninvasive marker for cardiac involvement in FMF patients.
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    Spectral domain-optical coherence tomographic findings in patients with ankylosing spondylitis under anti-tumor necrosis factor-alpha therapy
    (Taylor & Francis Ltd, 2015) Ilhan, Nilufer; Ustun, Nilgul; Tuzcu, Esra Ayhan; Coskun, Mesut; Yagiz, Abdullah Erman; Ilhan, Ozgur; Parlakfikirer, Nihan
    Objective: To evaluate the effect of tumor necrosis factor-alpha (TNF-alpha) blockade on the thickness of the peripapillary retinal nerve fiber layer (RNFL), the ganglion cell-inner plexiform layers (GCIPL), and the macula in ankylosing spondylitis (AS) patients under anti-TNF-alpha therapy. Materials and methods: Twenty-one patients with AS received etanercept, or adalimumab, or infliximab for at least 6 months. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were measured before and 6 months after the beginning of the treatment. Peripapillary RNFL, four regional fields (superior, inferior, nasal, and temporal), GCIPL, and macular thicknesses of the patients were analyzed by optical coherence tomography before the treatment, at 3 months and 6 months after the beginning of the treatment. Results: The mean BASDAI, ESR, and CRP values were 5.2 +/- 1.5, 31.6 +/- 21.7, and 15.7 +/- 13.9, respectively, at the beginning of the treatment and 2.3 +/- 1.7, 21.3 +/- 15.1, and 10.1 +/- 10.3, respectively, 6 months after the beginning of treatment. There were significant differences among the mean BASDAI, ESR, and CRP values at the beginning of treatment and 6 months later (p < 0.001, p = 0.007, and p = 0.009, respectively). There were no significant differences among peripapillary RNFL (p = 0.24), four regional fields (p = 0.98, p = 0.23, p = 0.09, p = 0.47), GCIPL (p = 0.25), or macular (p = 0.33) thicknesses of the patients during anti-TNF-alpha treatment. In addition, the mean intraocular pressure levels throughout the follow-up did not show significant variation on repeated-measures ANOVA (p = 0.77). Conclusions: TNF-alpha blockade does not seem to influence RNFL, GCIPL, or macular thickness of patients with AS in the short term.