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    Ankilozan spondilitli hastalarda parvovirüs B19 seropozitifliği
    (2014) Köksaldı Motor, Vicdan; Üstün, Nilgün; Evirgen, Ömer; İnci, Melek; Yula, Erkan; Önlen, Yusuf
    Amaç: Parvovirüs B19 viral artritlerin en sık nedenlerindendir. Bazı hastalarda romatoid artrit benzeri kronik bir poliartrite neden olması, parvovirüs B19'un otoimmün hastalıkların patogenezinde önemli bir etken olabileceğini düşündürmektedir. Bu çalışmada, ankilozan spondilitli (AS) hastalarda parvovirüs B19 seropozitifliğinin araştırılması amaçlanmıştır.Gereç ve Yöntemler: Ankilozan spondilit tanısı ile takip edilen 43 kişi hasta grubunu, herhangi bir kemik eklem şikayeti olmayan 70 kişi ise kontrol grubunu oluşturdu. Tüm serum örneklerinde ELİSA yöntemi ile anti parvovirüs B19 IgM ve IgG antikorlarına bakıldı.Bulgular: Hasta ve kontrol grubu karşılaştırıldığında, parvovirüs B19 IgM pozitifliği AS'li hasta grubunda anlamlı olarak yüksek bulundu (p<0,001).Sonuç: Ankilozan spondilitli hastalarda yüksek oranda parvovirüs B19 IgM pozitifliğinin saptanması, bu hastalarda immün yetmezliğine bağlı virüsün reaktivasyonu veya persistansını düşündürmektedir.
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    Antifungal activity of several root canal sealers against Candida albicans
    (Taylor & Francis Ltd, 2013) Ozcan, Erhan; Yula, Erkan; Arslanoglu, Zeki; Inci, Melek
    Objective. The purpose of this in vitro study was to evaluate the antifungal activity of several root canal sealers (iRoot SP, MTA Fillapex and GuttaFlow) against Candida albicans and compare them to that of AH Plus Jet. Materials and methods. A10 mu L fungi in suspension was allowed to directly contact the sealers, which were freshly mixed or allowed to set for 1 or 7 days. Fresh media was then added and survival of fungi was determined by using 10-fold serial dilution and inoculated onto agar plates. After incubation for 48 h, colony-forming units (CFU) were calculated and their log(10) values converted. The data were analyzed using ANOVA and Tukey tests (alpha = 0.05). Results. Freshly mixed AH Plus Jet totally inhibited the growth of fungi and showed the highest antifungal activity. GuttaFlow did not show any significant antifungal activity at all times. Freshly mixed iRoot SP and MTA Fillapex were found to be antifungal. Statistical differences were found between freshly mixed and set samples (p < 0.05) in favor of the former, except GuttaFlow. No statistically significant differences were found among the tested sealers at the 1 and 7-day samples (p > 0.05). Conclusions. Fresh AH Plus Jet had very potent antifungal activity. All sealers, except GuttaFlow, exhibited antifungal activity when freshly mixed.
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    Antimicrobial effects of several calcium silicate-based root-end filling materials
    (Japanese Soc Dental Materials Devices, 2014) Damlar, Ibrahim; Ozcan, Erhan; Yula, Erkan; Yalcin, Muhammet; Celik, Salih
    The purpose of this study was to evaluate, in vitro, the antimicrobial effect of iRoot BP, iRoot BP Plus, and mineral trioxide aggregate (MTA) against Entercoccus faecalis and Candida albicans by using direct contact test. The materials were tested immediately after application to the microtiter wells and after setting for 1-day and for 7-days. Ten microliters of microbial suspension was added to each well for direct contact with each material for 1 h at 37 degrees C and 100% humidity. Then fresh media was added and, survival of bacteria and fungi was determined by using 10-fold serial dilution and inoculated onto agar plates. In fresh and 1-day samples all of tested materials showed statistically significant antimicrobial effects compared to control groups (p<0.05). In 7-day samples, there were no significantly differences compared to control groups. MTA, iRoot BP and iRoot BP Plus had similar antimicrobial efficacy against E. faecalis and C. albicans.
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    Assessment of the levels of nitric oxide (NO) in chronic diarrhea patients infected with Giardia intestinalis
    (Academic Journals, 2012) Kaya, Ozlem M. Aycan; Atambay, Metin; Yula, Erkan; Ozyalin, Fatma; Motor, Vicdan Koksaldi; Motor, Sedat; Celik, Murat
    Giardia intestinalis is an enteric pathogen causing certain digestive disorders by attaching itself on the human intestine and, especially on the duodenum. It is reported that there is a strong relationship between the nitric oxide (NO) level and the clinical prognosis of the infection in infections of G. intestinalis. The aim of the study was to investigate serum NO levels in samples taken from patients with G. intestinalis detected in the microscopic stool examination and from the control group consisting of healthy people and the presence of any relationship with Giardiosis. The study consisted of 60 patients diagnosed with G. intestinalis in microscopic stool examination, [31 (51.7%) male, 29 (48.3%) female] and 60 healthy people [28 (46.7% male, 32 (53.5%) female] as the control group. All patients in the patient group with gastrointestinal symptoms had chronic diarrhea and cysts and trophozoites were observed in microscopic examination of the feces in all of them. Measurement of serum NO level was performed using Cortas method. When the data were evaluated by T-test in the Independent Groups, NO levels in the patient group was found low at a statistically significant level. In Giardiosis, the decline in the NO level suggested that the disease causes a more severe clinical presentation. In addition to this, we consider it necessary that extensive experimental or clinical studies be conducted on the subject.
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    Bir devlet hastanesinde intestinal parazit dağılımı ve etiyolojik analiz raporu
    (2011) Yula, Erkan; Deveci, Özcan; İnci, Melek; Tekin, Alicem
    Amaç: İntestinal parazitler, özellikle gelişmekte olan ülkeler başta olmak üzere küresel olarak yaklaşık dört milyar insanı etkileyen önemli bir halk sağlığı sorunudur. Bu çalışma; çoklu (mikst) intestinal parazit prevalansını ve potansiyel infeksiyon kaynağını belirlemek amacıyla yapılmıştır. Gereç ve yöntem: Çalışmaya 4 aylık periyotta, Kızıltepe Devlet Hastanesi Mikrobiyoloji Laboratuvarına paraziter etken varlığının araştırılması amacıyla gönderilen 1620 dışkı örneği prospektif olarak dahil edildi. Makroskobik inceleme sonrası dışkı örnekleri, dışkı konsantratör tüpü ile çöktürülüp kopro-parazitolojik yöntemlerden nativ-lugol yöntemi uygulanarak intestinal parazitler yönünden incelendi. Dışkı örneklerinin tamamı Entamoeba histolytica/dispar taraması için ticari test kiti kullanılarak Mikro-ELISA yöntemi ile adhezin antijen varlığı yönünden araştırıldı. Bulgular: Çalışmada, toplam 1620 insan dışkı örneği incelendi ve 447’si (% 27.6) intestinal parazitler yönünden olumlu bulundu. Enfekte dışkı örnekleri arasında; 63’ünün (% 14.1) iki parazit ve 18’inin (% 4.0) üç parazit ile çoklu infekte olduğu görüldü. Giardia intestinalis (% 43.3), Taenia spp. (% 36.4) ve Trichomonas hominis (% 5.4) en sık tespit edilen parazitlerdi. Çoklu parazitle (G. intestinalis & Taenia spp.) infekte dışkı örneklerinde kadın ve erkekler arasında cinsiyet açısından istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Sonuç: Bulgularımız bölgemizde parazitik infeksiyonların endemik kalmaya devam ettiğini göstermektedir.
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    Brusellozda Brucellacapt (Immunocapture-agglutination) ve Rose Bengal testlerinin değerlendirilmesi
    (2015) Yula, Erkan; Toka Özer, Türkan; Köksaldı Motor, Vicdan; Yengil, Erhan; İnci, Melek; Aksoy, Hüseyin; Kılınç, Çetin
    Amaç: Bruselloz, Gram negatif bir bakteri olan brusella türlerinin neden olduğu son derece bulaşıcı bir zoonotik hastalıktır. İnsan brusellozunun tanısında çok çeşitli serolojik testler kullanılmaktadır. Brusellozun serolojik tanısında sıklıkla tercih edilen yöntem olan tüp aglütinasyon testi, blokan antikor varlığını tespit edemediğinden yalancı negatif sonuçlara yol açabilmektedir. Bu çalışmada farklı iki test olan Rose Bengal testi (RBT) ve immuncapture- aglütinasyon (Brucellacapt) testi sonuçlarının analiz edilmesi ve bu testlerin kullanılabilirliğinin değerlendirilmesi amaçlanmıştır.Materyal Metod: Çalışmaya, Ağustos 2009 - Ağustos 2011 tarihleri arasında Kızıltepe Devlet Hastanesi mikrobiyoloji laboratuarına çeşitli polikliniklerden gelen 220 hastadan alınan serum örneği dahil edilmiştir. Her bir hasta serumunda hem RBT (ADR Diagnostics, Medico Chemistry) hem de Brucellacapt (ADR Diagnostics, Medico Chemistry) testleri çalışılmıştır. Her iki test de üretici firmanın talimatları doğrultusunda gerçekleştirilmiştir. Brucellacapt testinde 1/160 serum titresi eşik değer olarak kabul edilmiştir. Çalışma grubuna klinik bulgulara dayanarak bruselloz şüphesi olan 220 hasta dahil edilmiştir.Bulgular: Serum örneklerin serolojik olarak incelenmesi ile her iki test 146 (%66,4) hastada negatif bulunurken, hem RBT hem de Brucellacapt testinin pozitif olduğu hasta sayısı ise 59 (%26,8) olarak bulunmuştur. Ek olarak sadece RBT testinin pozitif olduğu hasta sayısı 9 (%4,1), sadece Brucellacapt testinin pozitif olduğu hasta sayısı ise 6 (%2,7) olarak tespit edilmiştir. Toplamda RBT 68 hastada (%30,9), Brucellacapt testi ise 65 hastada (%29,5) pozitif olarak bulunmuştur.Sonuç: Bölgemizde brusellozun endemik bir problem olarak devam ettiği tespit edilmiştir. RBT, bruselloz tanısında, tecrübeli eleman gerektirmeyen, yorumlanması kolay, maliyeti düşük ve teknik olarak da kolay uygulanabilir bir testdir. Brucellacapt testi de kolay ve pratik bir test olup bruselloz tanısında tamamlayıcı bir test olarak kullanılabilir.
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    Candida colonization in children with cerebral palsy
    (Duzce University Medical School, 2014) Başarslan, Fatma; İnci, Melek; Motor, Vicdan Köksaldı; Yula, Erkan; Kaya, Sadık; Yılmaz, Cahide
    Purpose: The aim of this study was to investigate candida colonization in children with cerebral palsy. Materials and Methods: In the study, 71 patients who were diagnosed as cerebral palsy and 40 healthy children were included at the Child Neurology Outpatient Clinic of Faculty of Medicine, Mustafa Kemal University, between March and December 2011. The smear samples from four regions which were oral, axillary, inguinal and antecubital areas. Results: Within the investigated areas, it was found that the most common colonized region was mouth and the most frequent species was Candida albicans both the patients with cerebral palsy and control groups. When two groups were compared, it was seen that the colonization in the mouth was significantly different in both groups and the antibiotic usage in patients with cerebral palsy was associated with an increased colonization of the mouth and inguinal region. Conclusion: In patients with cerebral palsy, the use of antibiotics especially may predispose to colonization of candida which is more prominent in the mouth. © 2012 Düzce Medical Journal.
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    A case of acute hemorrhagic cystitis caused by salmonella paratyphi a in a pediatric patient
    (2012) Yula, Erkan; Deveci, Ozcan; Toka-Ozer, Turkan; Tekin, Alicem; Inci, Melek; Karakus, Ali
    It is a very rare medical condition that Urinary tract infection (UTI) caused by Salmonella species. Seven-year-old boy admitted to our hospital with complaint of lower abdominal pain, burning and pain during urination (dysuria), nausea and increased fever. The patient had normal vital signs but abdominal examination revealed bilateral suprapubic tenderness. In the laboratory, it was found the amount of hemoglobin 12.9 g/dL, red blood cell count 4.8 million/mm3, white blood cell count 11.800/mm3, platelet count 275.000/mm3, level of C-reactive protein 30.2 mg/L, serologically S. paratyphi A "O" antibody (1/160) and S. paratyphi A "H" antibody (1/320) positivity. Urine examination showed gross hematuria and leukocyte esterase was positive. Urine culture was performed and isolate obtained urine culture was identified with conventional methods. Result of urine culture was reported as Salmonella species and isolate was determined as Salmonella paratyphi A by using anti-sera during the advanced identification. Results of radiological imaging were found normal. The patient was diagnosed as acute hemorrhagic cystitis caused by S. paratyphi A and received ceftriaxone treatment for seven days and had a full recovery. We conclude that in case of acute hemorrhagic cystitis, S. paratyphi A should be considered as causative agent in endemic areas.
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    Detection of primary clarithromycin resistance of Helicobacter pylori and association between cagA+ status and clinical outcome
    (Springer, 2013) Yula, Erkan; Nagiyev, Togrul; Kaya, Ozlem Aycan; Inci, Melek; Celik, M. Murat; Koksal, Fatih
    Helicobacter pylori was examined in 110 patients (82 (74.5) with gastritis, 18 (16.4) with duodenitis, six (5.5) with duodenal ulcer and gastroesophageal reflux, and four (3.6 %) with normal) with gastrointestinal problems living in rural area, no history of macrolide use, and detected by culture (71.8) or direct detection from gastric biopsies by PCR (82.7 %). Also, cagA gene was identified using PCR and was found positive in 68/91 (74.7 %) strains. The prevalence of clarithromycin-resistant H. pylori was investigated by two methods including PCR-RFLP (7.7 (A2142G 1.1 and A2143G 6.6 %)) and twofold agar dilution (8.9 %) to detect phenotypic and genotypic status simultaneously. Among all the H. pylori positive patients, eight (8.8 %) isolates were found to be resistant to clarithromycin by at least one of the AD and/or PCR-RFLP methods. H. pylori positive rates were significantly correlated with patients' sex, age, and endoscopic findings (p = 0.040, < 0.001 and < 0.001, respectively). There were no differences in gender or endoscopic findings related to cagA (+) and cagA (-) patients. The gene of cagA was not significantly helpful in predicting the clinical outcome of H. pylori infection alone. In conclusion, we revealed that there was a low prevalence of primer clarithromycin resistance in patients living in rural area with no history of macrolide use. The prevalence of mutant strains among the macrolide-resistant H. pylori varies even geographically between close provinces.
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    The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus
    (Sage Publications Ltd, 2013) Gokce, Cumali; Aycan-Kaya, Ozlem; Yula, Erkan; Ustun, Ihsan; Yengil, Erhan; Sefil, Fatih; Rizaoglu, Hatice
    Objectives To measure the rate of Demodex folliculorum mite infestation in patients with type 2 diabetes mellitus and to investigate if it was related to blood glucose control. Methods Patients with type 2 diabetes were classified according to their glycosylated haemoglobin (HbA(1c)) level into two groups: a well controlled blood glucose group (HbA(1c)7%) and a poorly controlled blood glucose group (HbA(1c)>7%). A standardized skin surface biopsy method was used to determine if the patients had D. folliculorum infestation (>5 mites/cm(2) of skin). Results A total of 69 patients (38 female) were enrolled in the study. Seventeen (24.6%) patients had D. folliculorum infestation. There were no significant differences in age, sex or body mass index between patients with and without D. folliculorum infestations. A significantly higher proportion of patients with poor blood glucose control had D. folliculorum infestation compared with patients with well controlled blood glucose. Conclusions These current findings suggest that poor blood glucose regulation increases the susceptibility to D. folliculorum mite infestation in patients with type 2 diabetes.
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    Erkeklerde perine bölgesinde demodex folliculorum araştırılması
    (2012) İnci, Mehmet; Yula, Erkan; Kaya, Özlem; İnci, Melek; Yalçınkaya, Fatih Rüştü; Rifaioğlu, Emine Nur; Demirbaş, Onur
    Bu çalışmada erkeklerin perine bölgesinde Demodex folliculorum araştırılması amaçlandı. Çalışmaya çeşitli şikayetlerle üroloji polikliniğine başvuran 122 erkek hasta dahil edildi. Hastaların perine bölgeleri lokal deri bulgusu açısından değerlendirildi ve standart yüzeyel deri biyopsisi yöntemiyle örnekler alındı. Mikroskobik incelemede cm2’de 5 ve daha fazla Demodex sp. görülmesi pozitif olarak değerlendirildi. Çalışmaya dahil edilen hastaların yaş ortalaması 46.4 ± 18.3 yıl ( 18 -83 yıl) olarak belirlendi. Hastaların 15’inde (% 12.3) D. folliculorum pozitif olarak saptandı. D. folliculorum pozitif bulunan hastaların yaş ortalaması 61.93 ± 17.72 yıl, negatif olguların ise 44.26 ± 17.40 yıl olarak bulundu (p= 0.002). D. folliculorum pozitifliğine en sık benign prostat hipertrofisi olan hastalarda rastlandı. Üroloji hastalarında perine bölgesinde D. folliculorum akarları görülebilmekle birlikte etkenin varlığı özellikle çeşitli klinik bulguları olan hastaların yönetiminde göz önünde bulundurulmalıdır.
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    Fusidic acid resistance among staphylococci strains isolated from clinical specimens in a general hospital
    (2012) Toka Özer, Türkan; Yula, Erkan; Tekin, Alicem; Deveci, Özcan
    Amaç: Bu çalışmanın amacı, klinik örneklerden izole edilen stafilokok suşlarında fusidik asidin in vitro etkinliğinin araştırılmasıdır. Gereç ve yöntem: Çalışmaya çeşitli klinik örneklerden izole edilen 41 koagülaz negatif stafilokok (KNS) izolatı ile 18 Staphylococcus aureus suşu dahil edildi. Stafilokok izolatları besiyeri yüzeyindeki koloni morfolojisi, gram boyama, katalaz ve koagülaz testleri gibi konvansiyonel yöntemlerle identifiye edildi. İzolatların antimikrobiyal duyarlılıkları “Clinical and Laboratory Standards Institute (CLSI)” önerileri doğrultusunda Kirby-Bauer disk difüzyon yöntemi kullanılarak çalışıldı. Bulgular: İzole edilen S.aureus suşlarının % 72’si metisiline duyarlı (MSSA), % 28’i metisiline dirençli (MRSA) olarak tanımlandı. MSSA ve MRSA suşlarının fusidik asit duyarlılık oranları arasındaki fark istatistiksel olarak anlamlı bulunmadı (p=0.305). İzole edilen KNS’lerin % 29’u metisiline duyarlı (MS-KNS), % 71’i metisiline dirençli (MRKNS) olarak tanımlandı. MR-KNS ve MS-KNS suşlarının fusidik asit duyarlılık oranları arasında istatistiksel olarak anlamlı fark yoktu (p=0.490). Ancak, KNS ve S.aureus suşlarının fusidik asit duyarlılık oranları arasındaki fark istatistiksel olarak anlamlıydı (p<0.001). KNS suşları fusidik aside S.aureus suşlarından daha fazla dirençli bulundu. Sonuç: Bu çalışmada, metisilin direnci ile birlikte fusidik aside karşı da direnç gelişiminde artış olduğu gözlendi. KNS izolatları arasındaki fusidik aside direnç oranları S.aureus suşlarına göre önemli ölçüde artmıştır. Sonuç olarak, fusidik asit stafilokoklara bağlı enfeksiyonların tedavisinde hala bir alternatif olarak durmaktadır.
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    Hatay yöresindeki gebelerde toksoplazma lgG seroprevalansı ve avidite testinin tanıya katkısı
    (2013) Okyay, Ayşe Güler; Karateke, Atilla; Yula, Erkan; İnci, Melek; Benk Şilfeler, Dilek; Köksaldı Motor, Vicdan
    Amaç: Zorunlu hücre içi paraziti olan Toxoplazma gondii, dünyada sık görülen bir zoonoz olup, toksoplazmozis enfeksiyonuna neden olur. Enfeksiyon genellikle asemptomatik seyretmekle birlikte gebelik döneminde geçirildiğinde konjenital anomalili doğumlara, düşüklere, ölü doğum ve prematür doğuma neden olabilmektedir. Bu çalışmada, Hatay yöresindeki gebelerde Toxoplasma IgG ve IgM seroprevalansının saptanması amaçlanmıştır. Planlama: Çalışmaya 2007-2012 yılları arasında Hatay Mustafa Kemal Üniversitesi Kadın Hastalıkları ve Doğum polikliniğine başvuran 3340 gebe dahil edildi. Hastanemiz mikrobiyoloji laboratuvar kayıtları taranarak olguların Toxoplasma IgM ve IgG antikor test sonuçları retrospektif olarak incelendi. Toxoplazma IgM ve IgG testlerinin her ikisi birden pozitif olan 114 olguda ise IgG avidite testi yapıldı. Olgulara avidite testine göre tedavi, takip veya gebeliğin sonlandırılması önerildi. Değerlendirme parametreleri: Araştırmada % 3,6 (n:120 ) oranında IgM pozitişiği ve % 57 (n:1910 ) oranında ise IgG seropozitişiği saptandı. Avidite testi ile % 31 olguda yeni enfeksiyon tespit edildi. Yorum: Çalışmada Akdeniz bölgesinde özellikle Hatay ve yöresinde parazitin seropozitişiğinin dikkate değer düzeyde yüksek olduğu gözlenmiş olduğundan özellikle birinci trimesterdeki gebelerin ve gebelik planlayan kadınların rutin muayenelerinde Toxoplasma gondii antikor testi yapılması faydalı olabilir. Ayrıca, bölgemizde su ve hijyen açısından bilincin arttırılması için tedbirler alınmalıdır.
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    Higher frequency of methicillin resistant bacteria in children with familial mediterranean fever
    (Pakistan Medical Assoc, 2015) Yengil, Erhan; Cevik, Cengiz; Silfeler, Ibrahim; Yula, Erkan; Kurtoglu, Ibrahim Ahmet; Arica, Vefik; Ozer, Cahit
    Objective: To investigate resistant microorganisms in nasal mucosa of children with Familial Mediterranean Fever. Methods: The study was conducted from March to May 2013 at Mustafa Kemal University, Turkey, and comprised children with Familial Mediterranean Fever and healthy controls. All subjects had no history of antibiotic or local and/or systemic steroid use within the preceding 2 weeks. Nasal swab samples were obtained from all the subjects. Strain identification was done by using standard methods. SPSS 13 was used for statistical analysis. Results: Of the 151 subjects in the study, 73(48.34%) were cases and 78(51.65%) were controls. Among the cases, there were 26(35.6%) girls, while among the controls, there were 40(51.3%) girls (p=0.052). The mean age of the cases was 7.78+/-3.34 years (range: 3-15 years), while it was 8.15+/-2.71 years (range: 3-16) among the controls (p=0.208). Methicillin-resistant coagulase-negative staphylococcus and methicillin-resistant staphylococcus aureus were isolated in both the groups. The growth rate of resistant bacteria was 63% (n=46) in the cases, in the controls (p=0.003; odds ratio [OR]: 2.7; 95% confidence interval [CI]: 1.4-5.2). Among the controls, history of hospitalisation increased the risk for the presence of resistant bacteria by 7.7 fold (OR: 7.7; 95%CI: 1.4 - 40.4). Conclusion: Higher rates of resistant bacteria showed that they were at risk of comorbidities related to antibiotic resistance.
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    Identification of nasal bacterial flora profile and carriage rates of methicillin-resistant Staphylococcus aureus in patients with allergic rhinitis
    (Springer, 2014) Cevik, Cengiz; Yula, Erkan; Yengil, Erhan; Gulmez, M. Ihsan; Akbay, Ercan
    The aim of the present study was to evaluate the effect of allergic rhinitis (AR) on the nasal flora and colonization rates of resistant microorganisms in comparison to healthy individuals. This colonization may be important in terms of AR-related disorders, the resistant microorganisms' carriage, and its complications and co-morbidities. The study was performed with two groups. The study group was composed of 54 adult patients with AR. The control group was composed of 50 healthy individuals. None of the individuals in both groups have used any antibiotics, local or systemic steroid within the last month. Composition of bacterial nasal flora and carriage rates of methicillin-resistant Staphylococcus aureus (MRSA) were evaluated with conventional methods by taking nasal smears with a swab. In the study group, methicillin-sensitive coagulase-negative staphylococci (MRCNS) were detected in 30 %; whereas diphtheroids in 25 %, methicillin-resistant coagulase-negative staphylococci in 13 %, methicillin-sensitive S. aureus in 9 %, methicillin-resistant S. aureus in 3.7 %, and extended-spectrum beta lactamases-positive gram-negative bacilli (GR-ESBL+) in 3.7 % were detected. In the control group, methicillin-sensitive coagulase-negative staphylococci were detected in 54 %; whereas diphtheroids in 21 %, methicillin-resistant coagulase-negative staphylococci in 1.5 %, methicillin-sensitive S. aureus in 16 %, methicillin-resistant S. aureus in 1.5 %, Gr-ESBL(-) in 4 %, and viridians streptococci in 3 % were detected. It is found that the MRSA and MRCNS colonization is higher in patients with AR. This colonization may be important in terms of AR-related disorders, the resistant microorganisms' carriage, and its complications and co-morbidities in comparison to healthy subjects.
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    In vitro activity of quinupristin-dalfopristin, methicillin and vancomycin against staphylococcus strains isolated from clinical samples
    (2012) Yula, Erkan; Toka Özer , Türkan; Deveci, Özcan; Tekin, Alicem; Yanık, Keramettin; Durmaz, Süleyman
    Bu çalışmada, çeşitli klinik örneklerden izole edilen stafilokok suşlarında kinupristin-dalfopristin duyarlılık oranlarının araştırılması amaçlanmıştır. Çalışmaya, mikrobiyoloji laboratuvarına gönderilen çeşitli klinik örneklerden izole edilen 98 stafilokok suşu [74'ü koagülaz negatif stafilokok (KNS) ve 24'ü S. aureus] dahil edildi. Stafilokok suşları konvansiyonel yöntemler ile tanımlandı. Stafilokok suşlarının metisilin ve kinupristin-dalfopristin duyarlılığı Clinical and Laboratory Standards Institute (CLSI) önerileri doğrultusunda Kirby-Bauer disk difüzyon yöntemiyle çalışıldı. Ayrıca suşların vankomisin duyarlılığı E-test yöntemi ile araştırıldı. Çalışmada kalite kontrol suşu olarak S. aureus ATCC 25923 kullanıldı. İzole edilen KNS’lerin 53(% 72)’ü metisiline dirençli KNS (MR-KNS) ve S. aureus’ların ise 3(%13)’ü metisiline dirençli (MRSA) olarak tanımlandı. MRKNS’lerin 8(% 15)’i kinupristin-dalfopristine dirençli iken, metisiline duyarlı KNS'lerde (MS-KNS) kinupristindalfopristin direnci 1(%5) suşta tespit edildi. MSSA ve MRSA suşlarının hiçbirinde kinupristin-dalfopristin direnci tespit edilmedi. Suşların tamamının vankomisine duyarlı olduğu bulundu. Stafilokok suşlarının kinupristindalfopristine yüksek oranda duyarlı oldukları bulundu. Sonuç olarak vankomisin gibi kinupristin-dalfopristin kombinasyonun da özellikle dirençli Gram-pozitif kok enfeksiyonlarının tedavisinde alternatif olabileceğini düşünmekteyiz.
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    Increased Density of Demodex Folliculorum May be Related to Additional Risk Factors Reply
    (Acad Medical Sciences I R Iran, 2016) Dokuyucu, Recep; Kaya, Ozlem Aycan; Yula, Erkan; Ustun, Ihsan; Bayram, Fahri; Gokce, Cumali
    [Abstract Not Available]
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    Öğe
    [Investigating Demodex folliculorum in patients with urological cancer].
    (2012) Inci, Mehmet; Kaya, Ozlem Aycan; Inci, Melek; Yula, Erkan; Gökçe, Hasan; Rifaio?lu, M Murat; Demirtaş, Onur
    In this study, it was aimed to determine frequency of Demodex folliculorum infestation in patients with urological cancers. This study evaluated 49 patients with urological cancers; 31 sex-matched healthy individuals as a control group were included in the study between March 2011 and April 2012 at the Hospital of Mustafa Kemal University, School of Medicine, Urology Clinic. The demographic characteristics of the patients were recorded. Samples from the perineal region of the subjects were taken by standard method of superficial skin biopsy and evaluated by microscopy. Presence of five or more Demodex sp. in a cm < sup > 2 < /sup > was considered as positive. Mean age was found to be 60.2±18.6 years. D. folliculorum was found to be positive in 11 (22.4%) of the patients with cancer and in 1 (3.2%) of the subjects in the control group. It was found that D. folliculorum frequency was significantly higher in the cancer group compared to the control group. No significant difference was found among the cancer groups in terms of D. folliculorum detection. In the cancer group, mean age was significantly higher in D. folliculorum positive patients than negative ones. It should be kept in mind that D. folliculorum incidence may increase in immunosuppressive states, such as cancer.
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    Investigating virulence factors of clinical Candida isolates in relation to atmospheric conditions and genotype
    (Tubitak Scientific & Technological Research Council Turkey, 2012) Inci, Melek; Atalay, Mustafa Altay; Koc, Ayse Nedret; Yula, Erkan; Evirgen, Omer; Durmaz, Suleyman; Demir, Gonca
    Aim: To investigate some virulence factors in Candida species isolated from patients with suspected invasive fungal infection and to identify their relationship with Candida genotypes. Materials and methods: Overall 45 isolates (20 Candida albicans and 25 non-albicans Candida spp.) genotyped by rep-PCR were included in this study. Virulence factors were studied in both aerobic and anaerobic conditions. In isolates, egg yolk agar was used for determining phospholipase activity, while bovine serum albumin agar was used for proteinase activity, Tween-80 medium for esterase activity, and Sabouraud dextrose agar with sheep blood for hemolysin activity. Biofilm formation was detected by the microplate method. Results: In both Candida spp., it was found that hemolytic activity and proteinase activity were higher in aerobic conditions, whereas biofilm formation was higher in anaerobic conditions. It was also found that phospholipase and esterase activity were only detected in C. albicans isolates, which were found to be higher in aerobic conditions. No difference was found in virulence factors evaluated among the C. albicans genotypes. Conclusion: The amount of oxygen in the atmosphere may affect the virulence of Candida spp. Further comprehensive studies are needed in order to identify the relationship between Candida genotypes and virulence factors.
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    Investigation of mean platelet volume in people with chronic hepatitis C virus infection
    (Turkiye Klinikleri, 2013) Köksaldi Motor, Vicdan; Evirgen, Ömer; Önlen, Yusuf; Yula, Erkan; Büyükkaya, Eyüp; Çelik, M. Murat; Yengil, Erhan
    Objective: The mean platelet volume is a parameter routinely determined by complete blood count analyzer, and it is correlates with platelet function and activation. Platelet activation and aggregation play an important role in the pathophysiology of atherosclerosis. The mean platelet volume, which is a marker of platelet activation, is considered as a risk factor for atherothrombosis. Especially in recent years, many studies investigating the relationship between hepatitis C virus and atherosclerosis is noteworthy. The aim of the present study was to investigate mean platelet volume in people with chronic hepatitis C virus infection. Material and Methods: The patient group was constituted by 141 patients followed up due to chronic hepatitis C virus infection, while 107 healthy subjects acted as the control group. The data of patients with chronic hepatitis C virus infection and the control group were analyzed retrospectively. Results: The patients with chronic hepatitis C virus infection had a mean age of 53.5±12, 57 years, there were 57 (40.4%) males and 84 (59.6%) females. In the control group, there were 40 (37.4%) males and 67 (62.6%) females, and mean age was calculated as 53.2±12.8 years. While the platelet count was decreased in subjects with chronic hepatitis C virus infection, the mean platelet volume was increased. Conclusion: It was observed that mean platelet volume levels were not affected by the patient's genotype, RNA and alanine aminotransferase levels. The mean platelet volume was significantly higher in patients with chronic hepatitis C virus infection and this supported other investigations that established a connection between hepatitis C virus infection and the risk of atherothrombosis. © 2013 by Türkiye Klinikleri.