Effectiveness of oral direct acting antivirals in elderly chronic hepatitis C patients: real-world data
Yükleniyor...
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Türk Geriatri Derneği
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Objectives: Elderly cases have not been adequately representedin clinical trials with respect to chronic hepatitis C treatment. Extremely limited realworld data is available on new direct-acting antivirals in elderly patients. Herein, weaim to evaluate real-world data on new direct-acting antivirals used in the treatmentof chronic hepatitis C virus.Materials and Method: Medical records of 122 patients who started treatmentwith new direct-acting antivirals between January 2018 and December 2019 owingto chronic hepatitis C virus infection were analyzed retrospectively. Patients weredivided into two age groups: those younger than 65 years and those aged 65 andolder. Sustained virological response at 12 week rates were compared between thetwo groups. Sustained virological response at 12 week treatment efficacy analyseswere performed with both modified intention to tract and per protocol.Results: Sustained virological response in the 12th week post treatment wassimilar in both elderly patients and younger patients. Per protocol analysis was97.6% (42/43) vs. 100% (56/56) and modified intention to tract analysis was 91.3%(43/45) vs. 91.8% (56/61), respectively. The most common genotype of patientsaged 65 years and older were 1b 80%, and the most common genotype of patientsyounger than 65 years was 1b 57%.Conclusion: In the present study, Sustained virological response rates weresimilar in elderly patients compared to younger patients; however, very limitedinformation is available on the effectiveness and safety of new, recently approveddirect-acting antivirals in the elderly population.
Açıklama
Anahtar Kelimeler
Hepatitis C, Chronic, Antiviral Agents, Sustained Virologic Response, Turkey
Kaynak
Türk Geriatri Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
23
Sayı
4
Künye
ÇABALAK M,BAL T (2020). EFFECTIVENESS OF ORAL DIRECT ACTING ANTIVIRALS IN ELDERLY CHRONIC HEPATITIS
C PATIENTS: REAL-WORLD DATA. Türk Geriatri Dergisi, 23(4), 473 - 481. Doi: 10.31086/tjgeri.2020.185
