Effectiveness of oral direct acting antivirals in elderly chronic hepatitis C patients: real-world data

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dc.authorid0000-0003-1148-2247en_US
dc.authorid0000-0002-5315-122Xen_US
dc.contributor.authorÇabalak, Mehmet
dc.contributor.authorBal, Tayibe
dc.date.accessioned2021-12-13T08:18:28Z
dc.date.available2021-12-13T08:18:28Z
dc.date.issued2020en_US
dc.departmentTayfur Ata Sökmen Tıp Fakültesien_US
dc.description.abstractIntroduction: Objectives: Elderly cases have not been adequately representedin clinical trials with respect to chronic hepatitis C treatment. Extremely limited realworld data is available on new direct-acting antivirals in elderly patients. Herein, weaim to evaluate real-world data on new direct-acting antivirals used in the treatmentof chronic hepatitis C virus.Materials and Method: Medical records of 122 patients who started treatmentwith new direct-acting antivirals between January 2018 and December 2019 owingto chronic hepatitis C virus infection were analyzed retrospectively. Patients weredivided into two age groups: those younger than 65 years and those aged 65 andolder. Sustained virological response at 12 week rates were compared between thetwo groups. Sustained virological response at 12 week treatment efficacy analyseswere performed with both modified intention to tract and per protocol.Results: Sustained virological response in the 12th week post treatment wassimilar in both elderly patients and younger patients. Per protocol analysis was97.6% (42/43) vs. 100% (56/56) and modified intention to tract analysis was 91.3%(43/45) vs. 91.8% (56/61), respectively. The most common genotype of patientsaged 65 years and older were 1b 80%, and the most common genotype of patientsyounger than 65 years was 1b 57%.Conclusion: In the present study, Sustained virological response rates weresimilar in elderly patients compared to younger patients; however, very limitedinformation is available on the effectiveness and safety of new, recently approveddirect-acting antivirals in the elderly population.en_US
dc.identifier.citationÇABALAK M,BAL T (2020). EFFECTIVENESS OF ORAL DIRECT ACTING ANTIVIRALS IN ELDERLY CHRONIC HEPATITIS C PATIENTS: REAL-WORLD DATA. Türk Geriatri Dergisi, 23(4), 473 - 481. Doi: 10.31086/tjgeri.2020.185en_US
dc.identifier.doi10.31086/tjgeri.2020.185en_US
dc.identifier.endpage481en_US
dc.identifier.issn1304-2947
dc.identifier.issn1307-9948
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85100451964en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage473en_US
dc.identifier.trdizinid457853en_US
dc.identifier.urihttps://dx.doi.org/10.31086/tjgeri.2020.185
dc.identifier.urihttps://hdl.handle.net/20.500.12483/3346
dc.identifier.volume23en_US
dc.identifier.wosWOS:000605365100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTürk Geriatri Derneğien_US
dc.relation.ispartofTürk Geriatri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Cen_US
dc.subjectChronicen_US
dc.subjectAntiviral Agentsen_US
dc.subjectSustained Virologic Responseen_US
dc.subjectTurkeyen_US
dc.titleEffectiveness of oral direct acting antivirals in elderly chronic hepatitis C patients: real-world dataen_US
dc.typeArticleen_US

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