Serum neuron specific enolase and S-100B levels in hemodialysis and peritoneal dialysis patients
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayınevi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-NonCommercial 3.0 United States
Attribution-NonCommercial 3.0 United States
Özet
Objective: Neuron-specific enolase (NSE) and S-100B are brain-derived proteins, and their levels increase in brain injury. The aim of the study was
to determine serum S-100B and NSE levels in patients with end-stage renal disease undergoing hemodialysis (HD) and peritoneal dialysis (PD) and to
demonsrate how these levels were affected by the type of dialysis applied.
Methods: The study group consisted of age- and gender-matched 20 patients undergoing HD, 26 patients undergoing continuous ambulatory PD
(CAPD) and 21 healthy controls. Blood samples were obtained before and after dialysis in the HD patient group, and fasting blood samples were
obtained in the CAPD and control groups. The routine biochemical parameters were measured within two hours from all serum samples. The
remaining serum samples were stored at -80 °C until the day of analysis of the S-100B and NSE assays. Serum S-100B and NSE levels were measured
by chemiluminescence immunoassay method. Routine biochemistry tests were measured by colorimetric method using a biochemistry analyzer.
Results: Serum S-100B (0.11±0.06 ng/mL in HD, 0.13±0.09 ng/mL in CAPD and 0.05±0.03 ng/mL in controls) and NSE (12.7±5.99 ng/mL in HD,
9.26±5.52 ng/mL in CAPD and 6.82±2.36 ng/mL in controls) levels were higher in HD and CAPD groups compared to controls. S-100B and NSE levels
were higher after HD compared to before HD (p<0.001). There was a weak but significant correlation between S-100B and NSE levels (r=0.290;
p=0.006).
Conclusion: In this study, serum S-100B and NSE levels were found to be high in patients undergoing HD and PD. Serum S-100B and NSE concentrations
were higher in HD and CAPD patients. Increased S-100B and NSE levels may be associated with cerebrovascular events in patients with chronic renal
failure. They may also be important markers for the determination of cerebrovascular events.
Açıklama
Anahtar Kelimeler
Brain damage, End stage renal failure, Hemodialysis, Neuron-specific enolase, Peritoneal dialysis, S-100B
Kaynak
European Archives of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
35
Sayı
2
Künye
Alpdemir, M., Özcan, O., Alpdemir, M. F., Şeneş, M., Azak, A., Duranay, M., & Yücel, D. (2019). Serum Neuron Specific Enolase and S-100B Levels in Hemodialysis and Peritoneal Dialysis Patients. European Archives of Medical Research, 35(2), 83.
