Serum neuron specific enolase and S-100B levels in hemodialysis and peritoneal dialysis patients

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dc.authorid0000-0003-2625-0246en_US
dc.authorid0000-0001-7486-503Xen_US
dc.authorid0000-0003-3015-1478en_US
dc.authorid0000-0002-7924-5478en_US
dc.authorid0000-0001-6228-8829en_US
dc.authorid0000-0002-2893-4484en_US
dc.authorid0000-0001-5487-2857en_US
dc.contributor.authorAlpdemir, Medine
dc.contributor.authorÖzcan, Oğuzhan
dc.contributor.authorAlpdemir, Mehmet Fatih
dc.contributor.authorŞeneş, Mehmet
dc.contributor.authorAzak, Alper
dc.contributor.authorDuranay, Murat
dc.contributor.authorYücel, Doğan
dc.date.accessioned2020-09-07T11:00:17Z
dc.date.available2020-09-07T11:00:17Z
dc.date.issued2019en_US
dc.departmentTayfur Ata Sökmen Tıp Fakültesien_US
dc.description.abstractObjective: Neuron-specific enolase (NSE) and S-100B are brain-derived proteins, and their levels increase in brain injury. The aim of the study was to determine serum S-100B and NSE levels in patients with end-stage renal disease undergoing hemodialysis (HD) and peritoneal dialysis (PD) and to demonsrate how these levels were affected by the type of dialysis applied. Methods: The study group consisted of age- and gender-matched 20 patients undergoing HD, 26 patients undergoing continuous ambulatory PD (CAPD) and 21 healthy controls. Blood samples were obtained before and after dialysis in the HD patient group, and fasting blood samples were obtained in the CAPD and control groups. The routine biochemical parameters were measured within two hours from all serum samples. The remaining serum samples were stored at -80 °C until the day of analysis of the S-100B and NSE assays. Serum S-100B and NSE levels were measured by chemiluminescence immunoassay method. Routine biochemistry tests were measured by colorimetric method using a biochemistry analyzer. Results: Serum S-100B (0.11±0.06 ng/mL in HD, 0.13±0.09 ng/mL in CAPD and 0.05±0.03 ng/mL in controls) and NSE (12.7±5.99 ng/mL in HD, 9.26±5.52 ng/mL in CAPD and 6.82±2.36 ng/mL in controls) levels were higher in HD and CAPD groups compared to controls. S-100B and NSE levels were higher after HD compared to before HD (p<0.001). There was a weak but significant correlation between S-100B and NSE levels (r=0.290; p=0.006). Conclusion: In this study, serum S-100B and NSE levels were found to be high in patients undergoing HD and PD. Serum S-100B and NSE concentrations were higher in HD and CAPD patients. Increased S-100B and NSE levels may be associated with cerebrovascular events in patients with chronic renal failure. They may also be important markers for the determination of cerebrovascular events.en_US
dc.identifier.citationAlpdemir, M., Özcan, O., Alpdemir, M. F., Şeneş, M., Azak, A., Duranay, M., & Yücel, D. (2019). Serum Neuron Specific Enolase and S-100B Levels in Hemodialysis and Peritoneal Dialysis Patients. European Archives of Medical Research, 35(2), 83.en_US
dc.identifier.doi10.4274/eamr.galenos.2018.46338en_US
dc.identifier.endpage87en_US
dc.identifier.issn2651-3137
dc.identifier.issn2651-3153
dc.identifier.issue2en_US
dc.identifier.startpage83en_US
dc.identifier.trdizinid330881en_US
dc.identifier.urihttps://dx.doi.org/10.4274/eamr.galenos.2018.46338
dc.identifier.urihttps://hdl.handle.net/20.500.12483/3053
dc.identifier.volume35en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayınevien_US
dc.relation.ispartofEuropean Archives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectBrain damageen_US
dc.subjectEnd stage renal failureen_US
dc.subjectHemodialysisen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectPeritoneal dialysisen_US
dc.subjectS-100Ben_US
dc.titleSerum neuron specific enolase and S-100B levels in hemodialysis and peritoneal dialysis patientsen_US
dc.typeArticleen_US

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