Investigation of apoptotic effects of hypericum perforatum extract on breast cancer cell line
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Harran Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-NonCommercial 3.0 United States
Attribution-NonCommercial 3.0 United States
Özet
Abstract: Hypericum perforatum has biological active contents affecting a variety of proteins such as caspase-3, bcl-2, and
bax, which mediate apoptosis known as programmed cell death and exerting anti-inflammatory effect. Apoptotic pathways
are important for cancers, chemotherapeutic resistance, and cancer development. Anti-inflammatory agents are also a
potential target for cancer. Therefore, it was aimed to investigate the activity of caspase-3 and the expressions of bcl-2, bax,
wee 1, gadd153, grp78, AIF, iNOS, COX-2, cPLA2, and NF-κB in H. perforatum extract-treated breast cancer (BC) cells in this
study. The activity of caspase-3 and the expressions of these proteins were determined in the cells by ELISA. The HP extract
increased the activity of caspase-3 and the expressions of bax, wee 1, gadd153, grp78 and AIF, and decreased the
expressions of bcl-2, COX-2, iNOS, cPLA2 and NF-κB in the BC cells. In the light of these findings, HP extract could help to
inhibit grow of BC cells and its anti-inflammatory effect may contribute this effect.
Açıklama
Anahtar Kelimeler
Hypericum perforatum, Breast cancer, Apoptosis, Inflammation
Kaynak
Harran Üniversitesi Veteriner Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
2
Künye
Harun, A. L. P., TUTUN, H., KAPLAN, H. M., ŞİNGİRİK, E., & ALTINTAŞ, L. (2019). Investigation of Apoptotic Effects of Hypericum perforatum Extract on Breast Cancer Cell Line. Harran Üniversitesi Veteriner Fakültesi Dergisi, 8(2), 198-202.
