Investigation of apoptotic effects of hypericum perforatum extract on breast cancer cell line

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dc.authorid0000-0002-9799-9556en_US
dc.authorid0000-0001-9512-8637en_US
dc.authorid0000-0003-3921-4957en_US
dc.authorid0000-0003-1219-6744en_US
dc.authorid0000-0002-5148-723Xen_US
dc.contributor.authorAlp, Harun
dc.contributor.authorTutun, Hidayet
dc.contributor.authorKaplan, Halil Mahir
dc.contributor.authorŞıngırık, Ergin
dc.contributor.authorAltıntaş, Levent
dc.date.accessioned2020-09-03T10:28:49Z
dc.date.available2020-09-03T10:28:49Z
dc.date.issued2019en_US
dc.departmentTayfur Ata Sökmen Tıp Fakültesien_US
dc.description.abstractAbstract: Hypericum perforatum has biological active contents affecting a variety of proteins such as caspase-3, bcl-2, and bax, which mediate apoptosis known as programmed cell death and exerting anti-inflammatory effect. Apoptotic pathways are important for cancers, chemotherapeutic resistance, and cancer development. Anti-inflammatory agents are also a potential target for cancer. Therefore, it was aimed to investigate the activity of caspase-3 and the expressions of bcl-2, bax, wee 1, gadd153, grp78, AIF, iNOS, COX-2, cPLA2, and NF-κB in H. perforatum extract-treated breast cancer (BC) cells in this study. The activity of caspase-3 and the expressions of these proteins were determined in the cells by ELISA. The HP extract increased the activity of caspase-3 and the expressions of bax, wee 1, gadd153, grp78 and AIF, and decreased the expressions of bcl-2, COX-2, iNOS, cPLA2 and NF-κB in the BC cells. In the light of these findings, HP extract could help to inhibit grow of BC cells and its anti-inflammatory effect may contribute this effect.en_US
dc.identifier.citationHarun, A. L. P., TUTUN, H., KAPLAN, H. M., ŞİNGİRİK, E., & ALTINTAŞ, L. (2019). Investigation of Apoptotic Effects of Hypericum perforatum Extract on Breast Cancer Cell Line. Harran Üniversitesi Veteriner Fakültesi Dergisi, 8(2), 198-202.en_US
dc.identifier.doi10.31196/huvfd.667748en_US
dc.identifier.endpage202en_US
dc.identifier.issn2146-717X
dc.identifier.issn2146-7188
dc.identifier.issue2en_US
dc.identifier.startpage198en_US
dc.identifier.trdizinid324598en_US
dc.identifier.urihttps://dx.doi.org/10.31196/huvfd.667748
dc.identifier.urihttps://hdl.handle.net/20.500.12483/3020
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherHarran Üniversitesien_US
dc.relation.ispartofHarran Üniversitesi Veteriner Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectHypericum perforatumen_US
dc.subjectBreast canceren_US
dc.subjectApoptosisen_US
dc.subjectInflammationen_US
dc.titleInvestigation of apoptotic effects of hypericum perforatum extract on breast cancer cell lineen_US
dc.title.alternativeMeme kanseri hücre hattında hypericum perforatum ekstresinin apoptotik etkilerinin araştırılmasıen_US
dc.typeArticleen_US

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