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Öğe Amitriptyline and tianeptine poisoning treated by naloxone(Sage Publications Ltd, 2010) Ari, Mustafa; Oktar, Suleyman; Duru, MehmetIntroduction: Severe amitriptyline toxicity may cause cardiac dysrhythmias, severe hypotension, convulsions and CNS depression, including coma. Management with gastric lavage, activated charcoal, alkalinization and supportive care with mechanical ventilation, antiarrhythmics and anticonvulsants, if required, is the general approach. Case report: A 33-year-old woman who has taken overdose antidepressants (amitriptyline and tianeptine) was admitted to the emergency service. She was intubated because she had pure respiratory arrest. Besides hypotension (80/60 mmHg), she was unresponsive to verbal and painful stimuli and her Glasgow coma score was 6. Hemogram and serum biochemical parameters and electrocardiography were within normal limits. The patient was examined for substance dependence and no trace of the injector was found in the body. Patient underwent a coma cocktail (naloxone 2 mg/kg, 5% dextrose 25 g/body and tiamin 100 g/body). Activated charcoal and intravenous alkalinization by NaHCO3 were initiated. Spontaneous respiration started again 20 min after being given the coma cocktail. She became responsive to verbal stimuli first hour after the coma cocktail, and her Glasgow coma score improved to 13. She had spent 2 days in the service and was discharged by the second day of admission, without any complications. Discussion: Herein, we report successful treatment in a case of severe amitriptyline and tianeptine poisoning by naloxone in addition to the above supportive care. Naloxone treatment may have a beneficial role in lethal doses of amitriptyline ingestion because amitriptyline may affect opioid receptors.Öğe Amotivational syndrome: less known and diagnosed as a clinical(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Ari, Mustafa; Sahpolat, Musa; Kokacya, M. Hanifi; Copoglu, U. SertanAmotivational syndrome (AS) is a disorder that includes apathy, callousness and antisocial behavior in chronic cannabis users. Some of these effects may generally be seen in other central nervous system depressants as well. Therefore, to make these effects specific for this syndrome is still debated. AS is usually seen among men during puberty. In different studies, the incidence of AS in regular cannabis users has been reported as between 16 to 21%. Although the causes accused in pathophysiology is still controversial, cannabis is the most commonly accused factor in the etiology. In neurobiology of the disease, noradrenergic and dopaminergic systems containing changes in limbic road have been blamed. The diagnosis is based on subjective complaints, and scored by clinical signs and Apathy Evaluation Scale (AES). There are very few experimental data available in treatment of AS, and clinical experience is very limited. By PubMed searching the keywords of 'amotivational syndrome, cannabis and amotivational syndrome, cannabis and motivation' from 1960 to December 2013, the published studies examining the relationship between marijuana and AS have been reviewed. We have reached 536 articles, of which 76 include direct relationship with AS, by the end of this search. Non-English articles were excluded from the study.Öğe A Case of Cannabis Use-Associated Psychotic Disorder Accompanied by Autoscopic Phenomena(Turkish Green Crescent Soc, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Sahpolat, Musa; Ari, MustafaCannabis (Marijuana) is one of the most commonly used illegal addictive substances. The psychiatric symptoms associated with cannabis use are agitation, insomnia, depressive or raised mood, anxiety, hallucinations, and concentration problems. It is known that cannabis use increases the risk for psychoses and bipolar disorders and may deteriorate the clinical presentation of pre-existing psychoses and bipolar disorders. A characteristic symptom of autoscopic psychosis is visual hallucination of some part or the entirety of a person's body, imitating his or her behaviors and being perceived as if seen in a mirror. This is not a specific symptom of any mental disorder and the cause is not definitively known. In this case presentation, the symptoms of a patient diagnosed with cannabis use-associated autoscopic psychosis are discussed in the context of the literature.Öğe Covid-19 and mental health(Duzce University Medical School, 2020) Ari, Mustafa; Duman, TaşkınBecause of their epidemic nature, infections such as coronavirus disease 2019 (COVID-19) pandemic cause neuropsychological and social problems which are significantly different from other known infections. Many studies on the COVID-19 pandemic have shown higher levels of mental problems such as anxiety, depression, panic disorder, and obsessive compulsive disorder especially in patients and individuals who are in the risk group. Due to biopsychosocial characteristics of people, infections, especially epidemic infections, seriously impair the quality of life by dramatically affecting these three structures, namely biology, psychology and social quality of life of a person. As numerous studies have shown, the entire human innate and adaptive immune system and the psychological and mental state of an individual are directly linked. Many studies have reported that quarantine and social restrictions can trigger depressive symptoms such as anxiety, obsession, and anhedonia. Some researchers have claimed that information from unknown sources on social media increases the psychological and psychosocial symptoms of obsession, anxiety and fear of death. Consequently, a multidisciplinary study is necessary in the treatment and prevention of coronavirus pandemic. © 2020, Duzce University Medical School. All rights reserved.Öğe DNA Methylation of BDNF Gene in Schizophrenia(Int Scientific Information, Inc, 2016) Copoglu, Umit Sertan; Igci, Mehri; Bozgeyik, Esra; Kokacya, M. Hanifi; Igci, Yusuf Ziya; Dokuyucu, Recep; Ari, MustafaBackground: Although genetic factors are risk factors for schizophrenia, some environmental factors are thought to be required for the manifestation of disease. Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity. It has been suggested that BDNF may play a role in the pathophysiology of schizophrenia. It is established that methylation status of the BDNF gene is associated with fear learning, memory, and stressful social interactions. In this study, we aimed to investigate the DNA methylation status of BDNF gene in patients with schizophrenia. Material/Methods: The study included 49 patients (33 male and 16 female) with schizophrenia and 65 unrelated healthy controls (46 male and 19 female). Determination of methylation pattern of CpG islands was based on the principle that bisulfite treatment of DNA results in conversion of unmethylated cytosine residues into uracil, whereas methylated cytosine residues remain unmodified. Methylation-specific PCR was performed with primers specific for either methylated or unmethylated DNA. Results: There was no significant difference in methylated or un-methylated status for BDNF promoters between schizophrenia patients and controls. The mean duration of illness was significantly lower in the hemi-methylated group compared to the non-methylated group for BDNF gene CpG island-1 in schizophrenia patients. Conclusions: Although there were no differences in BDNF gene methylation status between schizophrenia patients and healthy controls, there was an association between duration of illness and DNA methylation.Öğe Does helicobacter pylori cause psychiatric symptoms in dyspeptic patients?(Acta Medica Mediterranea, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, ErayObjective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not. In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-compulsive features, sensibility in interpersonal relations, anxiety, anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group got higher scores from the sub-groups of anxiety, obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index , the HP (-) group got higher scores from sub-scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub-scale are above eleven, which is cutoff score. Besides the group with HP (+) has been detected to get a score over 1 from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms. Individuals who suffer from dyspepsia had better get examined.Öğe DOES HELICOBACTER PYLORI CAUSE PSYCHIATRIC SYMPTOMS IN DYSPEPTIC PATIENTS?(Carbone Editore, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, ErayObjective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-coin. pulsive features, sensibility in interpersonal relations anxiety anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group :got higher scores from the sub groups of anxiety, Obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index, the HP (-) group got higher scores from sub scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub scale are above eleven;. which is cutoff score. Besides the group with Hp (+) has been detected to get a score. over I from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms: Individuals who suffer from dyspepsia had better get examined.Öğe Efects of isotretinoin on social anxiety and quality of life in patients with acne vulgaris: A prospective trial(2012) Yesilova, Yavus; Bez, Yasin; Ari, Mustafa; Turan, EnverSocial anxiety is common in acne patients and the effects of isotretinoin treatment on social anxiety symptoms have not yet been thoroughly investigated. The aim of the study was to assess the effects of isotretinoin treatment on the quality of life and social anxiety symptoms in a group of acne vulgaris patients. The Liebowitz Social Anxiety Scale (LSAS) and Short Form-36 (SF-36) were administered to 39 (24 female and 15 male) patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. The severity of acne was evaluated using the Global Acne Grading System. Thirty patients completed 6-month treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Acne significantly improved over time in the study group. The mean performance avoidance score in LSAS and mean pain and social functioning scores in SF-36 were significantly better at the end of isotretinoin treatment. In conclusion, isotretinoin treatment improves the quality of life and social anxiety symptoms in acne patients.Öğe The Effect of Agomelatine on the Nociceptive System(Kure Iletisim Grubu A S, 2014) Kivrak, Yuksel; Karademir, Basaran; Aygun, Hayati; Ersan, Yusuf; Ari, Mustafa; Karaahmet, Elif; Yagci, IbrahimObjective:The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive. system. Methods: Twenty four male Swiss albino mice (four months old and 28.8 +/- 1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50 degrees C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings. Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036). Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.Öğe Effects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgaris(Taylor & Francis Ltd, 2012) Yesilova, Yavuz; Bez, Yasin; Ari, Mustafa; Kaya, Mehmet Cemal; Alpak, GokayBackground: Depression, anxiety, and obsessive compulsive symptoms are known to be common among patients with acne vulgaris. In contrast to earlier reports, a number of recent studies suggested isotretinoin to be beneficial for depression and anxiety symptoms in acne patients. Moreover, its effects on obsessive compulsive symptomatology are still widely unknown. Objectives: To examine the effects of isotretinoin treatment on obsessive compulsive symptoms, depression, and anxiety in acne vulgaris patients. Methods: The Hospital Anxiety and Depression Scale, Maudsley Obsessive Compulsive Questionnaire, and Sheehan Disability Scale were administered to 43 patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. Severity of acne was evaluated with Global Acne Grading System. Thirty-three patients completed 6 months treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Results: Depression, anxiety, and obsessive rumination symptoms were significantly improved after isotretinoin treatment. On the other hand, obsessive doubting of acne patients was worse at the end of the treatment. There was no significant change in disease related disability of patients. Conclusion: Besides worsening of obsessive doubting, successful treatment with oral isotretinoin seems to be related with improvement in depression, anxiety, and obsessive rumination symptoms in acne vulgaris patients. These changes were not reflected in the disability level that acne patients have reported.Öğe Effects of Isotretinoin on Social Anxiety and Quality of Life in Patients with Acne Vulgaris: A Prospective Trial(Croation Dermatovenerological Soc, 2012) Yesilova, Yavus; Bez, Yasin; Ari, Mustafa; Turan, EnverSocial anxiety is common in acne patients and the effects of isotretinoin treatment on social anxiety symptoms have not yet been thoroughly investigated. The aim of the study was to assess the effects of isotretinoin treatment on the quality of life and social anxiety symptoms in a group of acne vulgaris patients. The Liebowitz Social Anxiety Scale (LSAS) and Short Form-36 (SF-36) were administered to 39 (24 female and 15 male) patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. The severity of acne was evaluated using the Global Acne Grading System. Thirty patients completed 6-month treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Acne significantly improved over time in the study group. The mean performance avoidance score in LSAS and mean pain and social functioning scores in SF-36 were significantly better at the end of isotretinoin treatment. In conclusion, isotretinoin treatment improves the quality of life and social anxiety symptoms in acne patients.Öğe Effects of season-induced hormonal changes on mortality(Medi+World Int, 2012) Helvaci, Mehmet Rami; Ari, Mustafa; Maden, Emin; Aydin, Leyla Yilmaz; Aydin, Yusuf; Ozer, CahitBackground: We tried to understand whether or not there are some seasonal differences in human mortality rates in the present study. Methods: The study was performed in the General Internal Medicine and Hematology Clinics between March 2007 and December 2010. All hospitalized cases in these units during the 45-month period were included into the study. The total number of deaths in each season were detected and compared. Results: There were 68 deaths during the period, with various causes. Although there were only three deaths in July, there were nine in October. In other words, the total number of deaths was the highest in autumn with 22 deaths (32.3% of all) in the 45-month period, totally. It was 13 (25.4%) in winter, 16 (23.5%) in spring, and 17 (25.0%) in the summer. Although there is obvious difference in the number of deaths between autumn and the other seasons, the difference was statistically nonsignificant probably due to the small number of death cases (p= 0.481). Conclusion: Although seasonal differences of human mortality rates were statistically nonsignificant, this was probably due to the small number of death cases of the present study; there may actually be a significant increase in autumn with unexplained reasons yet. Relative hormonal insufficiencies during the passage from a summer-like relaxed, to an autumn-like stressful season may be one of the causes. If so, it can be prevented by some hormonal replacement therapies, thus this theory should be searched with a higher number of cases in a more detailed approach.Öğe Elevated Monocyte to High-density Lipoprotein Ratios as an Inflammation Markers for Schizophrenia Patients(Korean Coll Neuropsychopharmacology, 2021) Sahpolat, Musa; Ayar, Duygu; Ari, Mustafa; Karaman, Mehmet AkifObjective: Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia. Methods: The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants. Results: The patients with schizophrenia had higher MHR values (15.04 +/- 3.31 in schizophrenia patients and 12.62 +/- 2.99 in controls; p = 0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, body mass index, severity of disease and MHR. Conclusion: To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.Öğe Examination of Anger Reactions and Psychiatric Diagnoses in Terms of Gender in a Group of University Students Having Difficulty with Anger Control(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2010) Ozen, Sakir; Bez, Yasin; Ari, Mustafa; Ozkan, MustafaObjective: We aimed to determine axis-I and axis-II diagnoses and identify gender difference in anger reactions among young adults who have difficulty controlling their anger. Method: Students from various faculties who had difficulty controlling their anger were invited to the psychiatry department. The SCID-I, SCID-II, Multidimensional Anger Scale, Childhood Trauma Questionnaire, Social Comparison Scale, Boratav Depression Screening Scale, and Beck Hopelessness Scale were administered to consecutive admissions of 50 males and 50 females. Results: Axis-I diagnoses were present in 60% of males and 74% of females. Axis-II diagnoses were present in 28% of males and 36% of females. Somatoform disorders and impulse control disorder were higher in males, whereas anxiety disorders and mood disorders were higher in females. Depression was diagnosed in 10% of males and 36% of females. Not being taken seriously was the most prominent reason for anger among females. The Revenge reactions score was strongly correlated with the education level of the mother in both genders (in females r=0.472, p=0.001; in males r=-0.396, p=0.006). The best predictor of an axis-I diagnosis in women was the anger symptoms total score, whereas it was the thoughts related to anger subscale score in males. On the other hand, the best predictors of an axis-II diagnosis were anxious behavior in females and smoking in males. Conclusion: Anger is an important component of psychiatric disorders. Reaction styles and underlying psychiatric disorders vary according to gender.Öğe Focusing on physical symptoms and psychological trauma of patients with bruxism(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2018) Sahpolat, Musa; Adiguzel, Mehmet; Ari, MustafaObjective: The aim of this study is to compare physical symptoms and childhood psychological trauma levels of bruxism patients with healty controls and to establish its relevance with sociodemographic characteristics. Material and Methods: This study was conducted in Department of Psychiatry in Mustafa Kemal University, Medical School and Faculty of Dentistry on 57 patients with bruxism and on 57 healthy controls who applied to outpatient clinics and accepted to join the study. Clinical diagnosis of bruxism was made according to Rugh and Harlan's criteria of selection. Sociodemographics data sheet, Somatosensory Amplification Scale (SSAS) and Childhood Trauma Questionnaire (CTQ) were applied by clinicians. Results: The mean age of patients with bruxism was determined 28.7 +/- 9.1 years, 63.1% (n=36) were women, 56.1% (n=32) were unmarried, and 54.3% (n=31) had low socioeconomic level. The mean SSAS score of patients with bruxism was detected statistically significantly higher than that of control group, but there was no statistically significant difference in the mean CTQ value between patient and control groups. There was positive and significantly correlation between CTQ and SSAS scores. Conclusion: In our study, increased focusing on physical symptoms, and a positive correlation between psychologic trauma and physical symptoms are defined in patients with bruxism. This fiunding points out that patients with bruxism may perceive normal physical sensations as intense, annoying and noxious. It is believed that individuals with bruxism seeking medical advice from different clinics may deserve a consultation to psychiatry clinics for diagnosis and treatment to define any underlying causes.Öğe High plasma nesfatin-1 level in patients with major depressive disorder(Pergamon-Elsevier Science Ltd, 2011) Ari, Mustafa; Ozturk, Oktay Hasan; Bez, Yasin; Oktar, Suleyman; Erduran, DuduAim: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group. Method: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels. Results: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r = 0.59, p<0.001) and in the control group (r = 0.58, p<0.001). Conclusion: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level. (C) 2010 Elsevier Inc. All rights reserved.Öğe Higher prevalence of metabolic syndrome and related factors in patients with first-episode psychosis and schizophrenia: a cross-sectional study in Turkey(Taylor & Francis Ltd, 2021) Sahpolat, Musa; Ari, MustafaBackground Schizophrenia patients (SPP) have an increased risk of metabolic syndrome (MetS) and are twice more likely to experience diabetes mellitus and obesity than the general population. Aims The main purpose of this study was to assess the prevalence of MetS and its components in first-episode psychosis patients (FEPP) and SPP. Methods This study consisted a total of 38 untreated FEPP, 40 SPP and 41 randomly selected healthy volunteers admitted to the psychiatric outpatient clinic. The diagnosis of MetS was made based on Adult Treatment Panel III (ATP III), ATP III-A and International Diabetes Federation (IDF) criteria. Results The prevalence of MetS was 26.3, 28.9 and 31.5% according to ATP III, ATP III-A and IDF criteria in the FEPP, respectively. The prevalence of MetS was 37.5, 40 and 42.5% according to ATP III, ATP III-A and IDF criteria in the SPP, respectively. The prevalence of MetS was 9.7, 9.7 and 12.2% according to ATP III, ATP III-A and IDF criteria in the control group, respectively. The prevalence of MetS was higher in female patients than male patients based on all three diagnostic criteria. The MetS patients had a higher mean of age, a longer duration of disease, and treatment compared to patients without MetS. Conclusion The current study found that FEPP and SPP had an increased prevalence of MetS. Especially, clinicians should pay attention to MetS in SPP due to the presence of risk factors, such as advanced age, being female, and long duration of disease and treatment.Öğe Increased Mean Platelet Volume in Patients with Depression(Derman Medical Publ, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal Turker; Kivrak, YukselAim: It is well known that the mean platelet volume (MPV) is a good indicator of platelet activity and the incidence of cardiovascular diseases. Major depressive disorder may emerge in association with the cardiovascular diseases. In this study, we aimed to investigate the relationship between MPV and major depressive disorder. Material and Method: MPV values of 65 patients with major depression were compared with 66 age-and sex-matched healthy subjects. Body mass index (BMI), MPV, platelet count (PLC) of all participants were measured. Beck Depression Scale (BDS) was performed to measure severity of depression. Results: MPV values of patients who had major depression were found to be significantly higher than the control group. Comparing Major Depression with the control group, there was no significant difference in terms of platelet count. In the depression group, there was no correlation between the severity of depression and MPV. Discussion: As a result, the mean platelet volume was determined to have a significant increase in major depressive disorder compared with healthy individuals. This also may be informative about the association between pathologies related vascular structure such as vascular atherosclerosis and depression.Öğe Increased mean platelet volume in patients with panic disorder(Dove Medical Press Ltd, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Kivrak, Yuksel; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal TurkerObjective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age-and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.Öğe Increased Plasma Nesfatin-1 Levels in Patients with Obsessive Compulsive Disorder(Kure Iletisim Grubu A S, 2012) Bez, Yasin; Ari, Mustafa; Ozturk, Oktay Hasan; Oktar, Suleyman; Can, YesimIncreased plasma nesfatin-1 levels in patients with obsessive compulsive disorder Objective:To determine and compare the plasma nesfatin-1 (a satiety peptide) levels of patients with obsessive compulsive disorder (OCD) and healthy control subjects. Method: Plasma nesfatin-1 levels of 31 patients with OCD (18 females, 13 males) and 28 healthy control subjects (16 females and 12 males) similar to the study group in terms of weight, age, and gender were measured in this study. Severity of obsessions and compulsions both in OCD patients and control subjects were determined by using Yale-Brown Obsessive Compulsive Scale (Y-BOCS). ELISA method was used to measure plasma nesfatin-1 levels. Results: Median plasma nesfatin-1 levels in patients with OCD and healthy control subjects were 4.61 ng/ml (min-max: 1.28-8.11) and 2.0 ng/ml (min-max: 0.11-4.98) respectively. The observed difference in plasma nesfatin-1 levels between two groups was statistically significant (p<0.001). No statistically significant correlation was observed between Y-BOCS scores and plasma nesfatin-1 levels either in the study group (r=0.205, p=0.27) or in the control group (r=0.335, p=0.071). Conclusion: Increased plasma nesfatin-1 levels observed in patients with OCD suggest a potential role to nesfatin-1 in anxiety states besides its previosly known anorexigenic effects.
